Attitudes toward aging and towards the needs of older people

In order to explore the underlying dimensionality of beliefs about aging, two sets of opinion statements (one dealing with general attitudes toward aging and the other with programmatic issues) were factor analyzed for two age groups: persons under 60 (N = 290) and persons 60 and older (N = 181). For the first set of social-psychological belief statements, a common factor structure was found for the two age groups. For the second set of programmatic statements, there was some communality between age groups, but most of the items loading on the factors tended to be age-specific. The belief structure of the older group was generally more complex and variegated than was the case with the younger group. Except where the items were personal relevance, positive and negative items tended to load on separate, unipolar factors.     

Changes of erythrocyte membrane lipids in ethanol induced hyperlipidemia (Zieve's syndrome) (author's transl)

In 11 patients with alcohol-induced hyperlipemia, of whom 6 showed a Zieve Syndrome increased phospholipids, triglycerides and total cholesterol were found in the red cells stromal. The gasliquid chromatographic analysis of the phospholipid fatty acids showed increased contents of saturated and monounsaturated fatty acids C 16-C 18 smaller contents of longchain highly unsaturated fatty acids. The changes in the fatty acid pattern mainly occurred in patients with Zieve Syndrome and could be important for the mechanism of the hemolytic anemia. Theses findings could be in connexion with vitamin E deficiency.     

Cardiac Arrhythmias and Sleep-Disordered Breathing in Patients with Heart Failure

The relationship between heart failure (HF), sleep-disordered breathing and cardiac arrhythmias is complex and poorly understood. Whereas the frequency of predominantly obstructive sleep apnea in HF patients is low and similar or moderately higher to that observed in the general population, central sleep apnea (CSA) has been observed in approximately 50% of HF patients, depending on the methods used to detect CSA and patient selection. Despite this high prevalence, it is still unclear whether CSA is merely a marker or an independent risk factor for an adverse prognosis in HF patients and whether CSA is associated with an increased risk for supraventricular as well as ventricular arrhythmias in HF patients. The current review focuses on the relationship between CSA and atrial fibrillation as the most common atrial arrhythmia in HF patients, and on the relationship between CSA and ventricular tachycardia and ventricular fibrillation as the most frequent cause of sudden cardiac death in HF patients.     

Price and capacity competition of application services duopoly

In this paper, we study the price and capacity competition of two application service providers (ASPs). The customers realize an intrinsic time-independent value from transactions processed by the ASP. The cost to the customers includes both the price charged by the ASP and the delay cost due to turnaround time of the ASP service system. Customers will choose to join the ASP who delivers a higher net value of the service. This paper examines the competition between two ASPs and the impact of customers' delay cost on ASP's pricing and capacity decisions. We find that the ASP with higher capacity will charge a higher price and enjoy a larger market share and, surprisingly, that customers' delay cost has no direct impact on the arrival rates to the ASPs but affects the ASPs' pricing decisions. The ASPs will charge a higher price premium to capitalize customers' higher delay cost. For the long-run problem, we find that in the presence of higher customer's delay cost, both ASPs' optimal profits suffer, in contrast to the short-run problem where a higher customer's delay cost leads to a higher profitability for both ASPs.     

Hybrid method for computing demagnetizing fields

A hybrid finite-element-boundary integral method is proposed for computing demagnetizing field. For a three-dimensional (3-D) mesh with N nodes in the magnetic region, the method requires storage O( N^4/3), and no nodes outside the magnetic region need to be considered. The method is suitable for nonlinear calculations, can be adapted to handle curved boundaries, and is especially convenient when the magnetic region consists of several parts whose relative positions are variable     

Performance analysis challenges and framework for high-performance reconfigurable computing

Reconfigurable computing (RC) applications employing both microprocessors and FPGAs have potential for large speedup when compared with traditional (software) parallel applications. However, this potential is marred by the additional complexity of these dual-paradigm systems, making it difficult to identify performance bottlenecks and achieve desired performance. Performance analysis concepts and tools are well researched and widely available for traditional parallel applications but are lacking in RC, despite being of great importance due to the applications’ increased complexity. In this paper, we explore challenges and present new techniques in automated instrumentation, runtime measurement, and visualization of RC application behavior. We also present ideas for integration with conventional performance analysis tools to create a unified tool for RC applications as well as our initial framework for FPGA instrumentation and measurement. Results from a case study are provided using a prototype of this new tool.     

Armstrong axioms and Boyce-Codd-Heath Normal Form under bag semantics

The theory of functional dependencies is based on relations, i.e. sets of tuples. Over relations, the class of functional dependencies subsumes the class of keys. Commercial database systems permit the storage of bags of tuples where duplicate tuples can occur. Over bags, keys and functional dependencies interact differently from how they interact over relations.We establish finite ground axiomatizations of keys and functional dependencies over bags, and show a strong correspondence to goal and definite clauses in classical propositional logic. We define a syntactic Boyce-Codd-Heath Normal Form condition, and show that the condition characterizes schemata that will never have any redundant data value occurrences in their instances. The results close the gap between the existing set-based theory of data dependencies and database practice where bags are permitted.     

An On-Line Technique for the Determination of the δ(18)O and δ(17)O of Gaseous and Dissolved Oxygen

Few studies have used the stable isotopic composition of O(2) as a tracer of gas transport or biogeochemical processes in environmental research. Here we demonstrate field sampling techniques for gaseous and dissolved O(2) and describe an analytical method for measuring δ(18)O and δ(17)O values of O(2) in air, soil gas, and water samples using continuous-flow isotope-ratio mass spectrometry (CF-IRMS). A Micromass CF-IRMS was altered to accommodate a sample gas injection port prior to a CO(2) and H(2)O trap and GC column. The GC column was a 1-m, 5-? molecular sieve column held at 35 °C. The resolved sample O(2) was introduced to the IRMS via an open split. δ(18)O and δ(17)O values were determined by measurement of O(2) isotopes at m/z 34/32 and 33/32 and comparison to a reference pulse of O(2). Repeated injections of atmospheric oxygen yielded a repeatability (±SD) of ±0.17‰ for δ(18)O and ±0.5‰ for δ(17)O. IRMS source linearity was excellent for O(2) over a sample size range of 60-400 μL. The smallest sample for routine δ(18)O and δ(17)O determinations was ～80 μL of O(2), with a sample analysis time of 180 s. Preliminary results from a riverine and soil gas study illustrate natural oxygen isotope fractionation processes.     

Physical and functional interactions between the herpes simplex virus UL15 and UL28 DNA cleavage and packaging proteins

Herpes simplex virus (HSV) DNA is cleaved from concatemers and packaged into capsids in infected cell nuclei. This process requires seven viral proteins, including UL15 and UL28. UL15 expressed alone displays a nuclear localization, while UL28 remains cytoplasmic. Coexpression with UL15 enables UL28 to enter nuclei, suggesting an interaction between the two proteins. Additionally, UL28 copurified with UL15 from HSV-infected cells after ion-exchange and DNA affinity chromatography, and the complex sedimented as a 1:1 heterodimer upon sucrose gradient centrifugation. These findings are evidence of a physical interaction of UL15 and UL28 and a functional role for UL15 in directing UL28 to the nucleus.     

Suppression of tumorigenicity of rat liver epithelial tumor cell lines by a putative human 11p11.2-p12 liver tumor suppressor locus

We have previously identified and mapped a locus within human chromosome 11p11.2-p12 that suppresses the tumorigenic potential of a rat liver tumor cell line (termed GN6TF) which contains well defined chromosomal aberrations involving rat chromosomes 1, 4, 7, and 10. In the present study, we investigated the potential of this human 11p11.2-p12 liver tumor suppressor locus to suppress the tumorigenic potential of two other rat liver tumor cell lines (GN3TG and GP10TA) following microcell-mediated introduction of human chromosome 11. These tumor cell lines are aneuploid and contain chromosomal abnormalities that are similar to the GN6TF tumor line. The tumorigenic potential and other phenotypic characteristics of GN3TG-11neo and GP10TA-11neo microcell hybrid (MCH) cell lines were variable, and dependent upon the status of the introduced human chromosome 11. MCH cell lines that retained the region of 11p11. 2-p12 delineated by microsatellite markers D11S1385 and D11S903 exhibited suppression of tumorigenicity in vivo (decrease in tumorigenicity and/or elongation of latency), whereas, the tumorigenic potential of one MCH line that lacked markers in this region of human 11p11.2-p12, but retained flanking markers, was not changed from that of the parental tumor cell line. The chromosomal interval between microsatellite markers D11S1385 and D11S903 encompasses the previously localized minimal liver tumor suppressor region, suggesting that a common locus is responsible for tumor suppression among the rat liver tumor cell lines examined. The results of the present study have verified the presence of a liver tumor suppressor locus within human 11p11.2-p12, and have identified a substantial number of microsatellite markers that are closely linked to this tumor suppressor region. These chromosomal markers will facilitate positional cloning of candidate genes from this region, and may prove useful for determining the involvement of this locus in the pathogenesis of human liver cancer.