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51.
D. M. Follstaedt S. M. Myers J. C. Barbour G. A. Petersen J. L. Reno L. R. Dawson S. R. Lee 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2000,160(4):476-498
The ion implantation of He is examined as a means to form thermally stable cavities in GaAs. Room-temperature implantation of 2–10 × 1016 He/cm2 at 40 or 50 keV forms bubbles, but subsequent annealing at 250°C or above leads to exfoliation of the implanted surface layer. The exfoliation appears related to the agglomeration of bubbles on dislocations at the back of the layer; evidence suggests these may be misfit dislocations formed to relieve compressive stress in the implanted layer. Implantation of He at 150°C produces similar results, whereas the He diffuses out of GaAs without forming cavities during implantation at 300°C. However, implantations of immobile Ar followed by He at 400°C produce extended defects with bubbles in the implanted layer; the He can be degassed by subsequent annealing at 400°C to produce 1.5–3.5 nm cavities that are stable at this temperature. The same treatment applied to an In0.10Ga0.90As/GaAs heterostructure produces larger cavities preferentially located on dislocations at the interface, with only slight reduction in strain of the epitaxial layer. The microstructures of both GaAs and the heterostructure clearly demonstrate an attractive interaction between bubbles or cavities and dislocations. 相似文献
52.
This paper address the tracking control problem of a induction motor driving a mechanical load. Based on the nonlinear dynamics of the induction motor, a robust tracking controller is developed which can compensate for parametric uncertainties and additive bounded disturbances throughout the entire electromechanical system. A uniform ultimate bounded (UUB) result is obtained for the rotor position tracking error. Simulation results with full state measurements and a flux observer are presented to illustrate the effectiveness of the proposed controller. 相似文献
53.
Mathew J. Jones Dr. Alice Dawson Prof. Tim G. Hales Prof. William N. Hunter 《Chembiochem : a European journal of chemical biology》2020,21(10):1526-1533
Bicuculline, a valued chemical tool in neurosciences research, is a competitive antagonist of specific GABAA receptors and affects other pentameric ligand-gated ion channels including the glycine, nicotinic acetylcholine and 5-hydroxytryptamine type 3 receptors. We used a fluorescence-quenching assay and isothermal titration calorimetry to record low-micromolar dissociation constants for N-methylbicuculline interacting with acetylcholine-binding protein and an engineered version called glycine-binding protein (GBP), which provides a surrogate for the heteromeric interface of the extracellular domain of the glycine receptor (GlyR). The 2.4 Å resolution crystal structure of the GBP:N-methylbicuculline complex, sequence and structural alignments reveal similarities and differences between GlyR and the GABAA receptor–bicuculline interactions. N-methylbicuculline displays a similar conformation in different structures, but adopts distinct orientations enforced by interactions and steric blocks with key residues and plasticity in the binding sites. These features explain the promiscuous activity of bicuculline against the principal inhibitory pentameric ligand-gated ion channels in the CNS. 相似文献
54.
Binding Mode and Structure–Activity Relationships around Direct Inhibitors of the Nrf2–Keap1 Complex
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Dr. Eric Jnoff Dr. Claudia Albrecht Dr. John J. Barker Dr. Oliver Barker Dr. Edward Beaumont Dr. Steven Bromidge Dr. Frederick Brookfield Dr. Mark Brooks Dr. Christian Bubert Dr. Tom Ceska Vincent Corden Dr. Graham Dawson Dr. Stephanie Duclos Dr. Tara Fryatt Dr. Christophe Genicot Dr. Emilie Jigorel Dr. Jason Kwong Rosemary Maghames Innocent Mushi Dr. Richard Pike Dr. Zara A. Sands Dr. Myron A. Smith Dr. Christopher C. Stimson Dr. Jean‐Philippe Courade 《ChemMedChem》2014,9(4):699-705
An X‐ray crystal structure of Kelch‐like ECH‐associated protein (Keap1) co‐crystallised with (1S,2R)‐2‐[(1S)‐1‐[(1,3‐dioxo‐2,3‐dihydro‐1H‐isoindol‐2‐yl)methyl]‐1,2,3,4‐tetrahydroisoquinolin‐2‐carbonyl]cyclohexane‐1‐carboxylic acid (compound (S,R,S)‐ 1 a ) was obtained. This X‐ray crystal structure provides breakthrough experimental evidence for the true binding mode of the hit compound (S,R,S)‐ 1 a , as the ligand orientation was found to differ from that of the initial docking model, which was available at the start of the project. Crystallographic elucidation of this binding mode helped to focus and drive the drug design process more effectively and efficiently. 相似文献
55.
Use of sequential ASE extraction to evaluate the bioavailability of DDT and its metabolites to wheat roots in soils with various organic carbon contents 总被引:10,自引:0,他引:10
Tao S Guo LQ Wang XJ Liu WX Ju TZ Dawson R Cao J Xu FL Li BG 《The Science of the total environment》2004,320(1):1-9
An accelerated solvent extraction (ASE) procedure using water, n-hexane and a mixture of n-hexane and acetone as solvents in sequence was developed and tested to evaluate the bioavailability of DDT and its metabolites including p,p'-DDT, o,p'-DDT, p,p'-DDE, and p,p'-DDD (SigmaDDTs) to wheat uptake from soils characterized by varied organic carbon contents. Results indicated that the extractability of SigmaDDTs with water was enhanced considerably in the presence of water soluble organic carbon (WSOC), while the amount of SigmaDDTs extracted with n-hexane was negatively correlated to the content of water insoluble organic carbon (WIOC). The interaction between SigmaDDTs and WIOC also reduced the bioavailability of the pesticides to wheat roots during uptake. There was a good positive correlation between the amount of SigmaDDTs extracted by n-hexane and the amount of SigmaDDTs accumulated in wheat roots, suggesting some potential for the use of the n-hexane ASE-extracted fraction as an indicator of SigmaDDTs' bioavailability to plant uptake. As such, the three sequentially extracted fractions may be viewed as representing the mobile, bioavailable, and fixed pools of SigmaDDTs in the soil. 相似文献
56.
Soy protein concentrate and heated soy flours as protein sources in milk replacer for preruminant calves 总被引:4,自引:0,他引:4
D P Dawson J L Morrill P G Reddy H C Minocha H A Ramsey 《Journal of dairy science》1988,71(5):1301-1309
Thirty-two male calves (8/treatment) in Trial 1 and 41 male and female calves (10 or 11/treatment) in Trial 2 were fed milk replacers containing 100% of the total protein from milk sources or 25% from milk and 75% from a soy product: soy protein concentrate; commercial heated (fully cooked) soy flour; or experimental soy flour for 6 wk. The experimental flour received moist heat sufficient to reduce trypsin inhibitor to 1 unit/mg. Calf performance improved with age on all diets. Growth, protein and dry matter digestibility, nitrogen retention, and morphology of the intestinal mucosa of calves on the all milk-protein diet were superior to those of calves on diets containing a soy product. All soy-fed groups had a humoral but no cell-mediated immune reaction to soy proteins. Soy protein concentrate and the experimental heated soy flour were superior to the commercial heated soy flour as protein sources for milk replacer. 相似文献
57.
The underlying basis for the behaviour of a population of cells is the cell growth and division cycles of the individual cells. Under certain special circumstances, oscillations in cell cultures can be observed that are a reflection of metabolic oscillations, such as in glycolysis, or cell cycle oscillations from a partially synchronized population. These oscillations can sometimes occur spontaneously, as in the chemostat culture of Saccharomyces cerevisiae at low dilution rates, or can be induced using chemical blockers or entrainment by a periodic nutrient environment. Continuous methods for inducing a synchronized culture include the pulsed chemostat, continuous phasing and self-cycling fermentation. Results obtained by studying both spontaneously oscillating cultures and synchronized cultures have provided insight into the mechanisms responsible for the progress and control of the cell cycle as well as the intimate relationship that exists between the cellular dynamics and the dynamics of the environment. 相似文献
58.
Jallipalli A. Kutty M.N. Balakrishnan G. Tatebayashi J. Nuntawong N. Huang S.H. Dawson L.R. Huffaker D.L. Mi Z. Bhattacharya P. 《Electronics letters》2007,43(22)
A GaSb quantum-well (QW) laser diode grown monolithically on a 5deg miscut Si (001) substrate is presented. The III-Sb epi-structure is grown monolithically on the miscut Si substrate via a thin (50 nm) AlSb nucleation layer. The 13% lattice mismatch between AlSb and Si is accommodated by a self-assembled 2D array of interfacial misfit dislocations (IMF). The 5deg miscut geometry enables simultaneous IMF formation and anti-phase domain suppression. The 1 mm times 100 mum GaSb QW laser diode operates under pulsed conditions at 77 K with a threshold current density of 2 kA/cm2 and a maximum peak power of ~20 mW. Furthermore, the device is characterised by a 9.1 Omega forward resistance and a leakage current density of 0.7 A/cm2 at -5 V. 相似文献
59.
A. Jallipalli G. Balakrishnan S. H. Huang T. J. Rotter K. Nunna B. L. Liang L. R. Dawson D. L. Huffaker 《Nanoscale research letters》2009,4(12):1458-1462
We report structural analysis of completely relaxed GaSb epitaxial layers deposited monolithically on GaAs substrates using
interfacial misfit (IMF) array growth mode. Unlike the traditional tetragonal distortion approach, strain due to the lattice
mismatch is spontaneously relieved at the heterointerface in this growth. The complete and instantaneous strain relief at
the GaSb/GaAs interface is achieved by the formation of a two-dimensional Lomer dislocation network comprising of pure-edge
(90°) dislocations along both [110] and [1-10]. In the present analysis, structural properties of GaSb deposited using both
IMF and non-IMF growths are compared. Moiré fringe patterns along with X-ray diffraction measure the long-range uniformity
and strain relaxation of the IMF samples. The proof for the existence of the IMF array and low threading dislocation density
is provided with the help of transmission electron micrographs for the GaSb epitaxial layer. Our results indicate that the
IMF-grown GaSb is completely (98.5%) relaxed with very low density of threading dislocations (105 cm−2), while GaSb deposited using non-IMF growth is compressively strained and has a higher average density of threading dislocations
(>109 cm−2). 相似文献
60.
Thanchanok Ratvijitvech Robert Dawson Andrea Laybourn Yaroslav Z. Khimyak Dave J. Adams Andrew I. Cooper 《Polymer》2014
Control over the surface functionality and microporosity in conjugated microporous polymers (CMPs) has been achieved by the post-synthetic modification of amines into amides of with different alkyl chains, one of which was chiral. The surface areas, pore volumes, carbon dioxide uptakes and isosteric heat of adsorption for carbon dioxide can be rationally tuned. 相似文献