Identification of kaempferol-3-rhamnoglucoside and quercetin-3-glucoglucoside in cottonseed

The flavonol glycosides, quercetin-3-glucoglucoside and kaempferol-3-rhamnoglucoside, have been separated from crushed, delinted cottonseed (kernel and hull) by extensive use of paper chromatography, ultraviolet spectrophotometry, and qualitative and quantitative analysis of their hydrolysis products. Details of the separation and identification are described. Aided by a Fellowship from the National Medical Fellowship Inc. through funds appropriated by the National Foundation for Infantile Paralysis.     

Sports capacity after rupture of the anterior cruciate ligament--surgical versus non-surgical therapy

Using a new rating system (Innsbruck Knee-Sports Rating Scale) 75 patients 5 to 6 years after ACL-injury have been compared to their sports activity (47 patients with ACL reconstruction and 28 conservative treated patients). Under the viewpoint of knee load and especially the demand on stability sports activities have been divided into 3 categories: High Risk, Low Risk and Non Risk Pivoting Sports. Operative therapy shows an advantage in High Risk Pivoting sports (e.g. soccer, basketball) and in Low Risk Pivoting (e.g. running, hiking) sports, expressed by fewer knee related symptoms and higher participation levels. In the Non Risk Pivoting category (e.g. swimming, cycling) good results could also be achieved by conservative therapy. The careful evaluation of each patient's sports activities is therefore an important factor in the decision for the right therapy on one hand, and for comparing the results of different therapy programs or patient collectives on the other.     

Cognitive profiles of difficult-to-remediate and readily remediated poor readers: Early intervention as a vehicle for distinguishing between cognitive and experiential deficits as basic causes of specific reading disability.

Reading impaired first graders were given daily tutoring as a "first cut" diagnostic to aid in distinguishing between reading difficulties caused by basic cognitive deficits and those caused by experiential deficits. Reading achievement in most of these children was found to be within or above the average range after one semester of remediation. Children who were difficult to remediate performed below both children who were readily remediated and normal readers on kindergarten and first-grade tests evaluating phonological skills, but not on tests evaluating visual, semantic and syntactic skills. The results are consistent with convergent findings from previous research suggesting that reading problems in some poor readers may be caused primarily by phonological deficits. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Intensive medical therapy versus coronary angioplasty for suppression of myocardial ischemia in survivors of acute myocardial infarction: a prospective, randomized pilot study

BACKGROUND: Patients who have inducible ischemia after acute myocardial infarction (AMI) generally undergo coronary angiography with the intent to revascularize. Whether this approach is superior to intensive treatment with anti-ischemic medications is unknown. METHODS AND RESULTS: We performed a prospective, randomized pilot study comparing intensive medical therapy with coronary angioplasty (PTCA) for suppression of myocardial ischemia in 44 stable survivors of AMI. Myocardial ischemia was quantified with adenosine 201Tl tomography (SPECT) performed 4.5+/-2.9 days after AMI. All patients at baseline had a large total (>/=20%) and ischemic (>/=10%) left ventricular perfusion defect size (PDS). SPECT was repeated at 43+/-26 days after therapy was optimized. The total stress-induced PDS was comparably reduced with medical therapy (from 38+/-13% to 26+/-16%; P<0.0001) and PTCA (from 35+/-12% to 20+/-16%; P<0.0001). The reduction in ischemic PDS was also similar (P=NS) in both groups. Cardiac events occurred in 7 of 44 patients over 12+/-5 months. Patients who remained clinically stable had a greater reduction in ischemic PDS (-13+/-9%) than those who had a recurrent cardiac event (-5+/-7%; P<0.02). Event-free survival was superior in the 24 patients who had a significant (>/=9%) reduction in PDS (96%) compared with those who did not (65%; P=0.009). CONCLUSIONS: In this small pilot study, intensive medical therapy and PTCA were comparable at suppressing ischemia in stable patients after AMI. Sequential imaging with adenosine SPECT can track changes in PDS after anti-ischemic therapies and thereby predict subsequent outcome. Corroboration of these preliminary findings in a larger cardiac-event trial is warranted.