An extension of Quasi-One-Dimensional Tomography

A method for rapid limited-angle tomography is suggested thatallows the reconstruction of density distribution in hardwood sampleswith high accuracy and spatial resolution from only a few x-rayprojections. The sparsity of the experimental x-ray data iscompensated by incorporation of a priori knowledge aboutgeneric wood macrostructure, as well as some morphological informationobtainable from optical images of the sample surface, in themathematical framework of the tomographic analysis. Numerical testsof the proposed method confirm its potential as a practical techniquefor nondestructive testing of trees for scientific and industrialpurposes. It can also be useful for the analysis of other types ofobject with an underlying layered structure.     

Biased motion-adaptive temporal filtering for speckle reduction in echocardiography

Describes a new fully motion-adaptive spatio-temporal filtering technique to reduce the speckle in ultrasound images. The advantages of this approach are demonstrated in echocardiographic boundary detection and in comparison with other techniques. The first stage of many automated echocardiographic image interpretation schemes is filtering to reduce the amount of speckle noise. The authors show how the two-dimensional least mean squares (TDLMS) filter can be configured as a motion-compensated filter for a time sequence of ultrasound images that eliminates the blurring associated with direct averaging. For an image corrupted by multiplicative speckle noise, the mode of the intensity distribution approximates the maximum likelihood estimator. In consequence, the temporal filter's output is biased towards the mode from the mean, using information contained within the speckle itself. A new adaptive algorithm for controlling the filter's convergence is also included. To evaluate performance, application to simulated, phantom, and an in vivo test sequence of the carotid artery are considered in comparison with other techniques. The effect of filtering on edges is of great importance, as these are used by subsequent image interpretation schemes. Quantitative measurements demonstrate the effectiveness of the Biased TDLMS filter, for both noise reduction and edge preservation. Echocardiographic images have a high noise content and suffer from poor contrast. Despite this challenging environment, the Biased TDLMS filter is shown to produce images that are better inputs for subsequent feature extraction. The benefits for echocardiographic images are highlighted by considering the problems of mitral valve analysis and extraction of the left atrium boundary.     

Helicobacter pylori does not migrate from the antrum to the corpus in response to omeprazole

BACKGROUND: Omeprazole is known to have an effect on Helicobacter pylori in vivo. One opinion is that H. pylori "migrates" from the antrum to the corpus in response to omeprazole therapy. METHODS: To determine whether H. pylori migrates in response to omeprazole, we assessed the presence of H. pylori in the antrum and corpus in duodenal ulcer patients receiving omeprazole for 4 wk. Culture and histological examination of antral biopsies (Genta stain) were performed before patients received omeprazole, at the end of therapy, and 4-6 wk later. The end points were presence or absence of H. pylori and the number of H. pylori colonies per biopsy. RESULTS: Seventy-two patients had H. pylori in both the antrum and corpus at entry and 4-6 wk after ending therapy. Three general patterns were prevalent at the end of omeprazole therapy: antrum- and corpus-positive (54%), antrum-negative and corpus-positive (24%), both antrum- and corpus-negative (21%), and one patient had antrum-positive with corpus-negative (1%). Evaluation of the number of colonies per biopsy in those who remained H. pylori-positive in both the antrum and corpus throughout showed that the number of H. pylori decreased in both the antrum and corpus during therapy (507 +/- 60 vs. 225 +/- 51, p < 0.01 and 415 +/- 58 vs. 290 +/- 46 0.1) for antrum and corpus, respectively, and tended to return to pre-therapy levels 4-6 wk later. The number of H. pylori in the corpus also decreased in the antrum-negative and corpus-positive group during therapy with omeprazole (433 +/- 87 vs. 185 +/- 61, p < 0.05). In most of the patients studied, the number of H. pylori in the corpus was less posttreatment than it was pretreatment. The decrease in H. pylori load was also reflected in the development of false-negative urea breath tests. CONCLUSIONS: Omeprazole is detrimental to H. pylori in both the antrum and the corpus; migration from the antrum to the corpus in response to omeprazole is a myth.     

Optimal head related transfer functions for hearing and monaural localization in elevation: a signal processing design perspective

Localization of sound sources by human listeners has been widely studied and theories and various models of the localization and hearing mechanism have been constructed. In the classical "duplex" theory, sound localization in azimuth is explained by interaural time or equivalently, phase differences at low frequencies, and by interaural amplitude differences at higher frequencies. Head related transfer functions (HRTF's) present a linear system approach to modeling localization by representing the direction-dependent transformation the sound undergoes at each ear. Localization in elevation is explained by directional differences in the HRTF's, which also explains monaural localization. We conjecture that the HRTF's evolved during the course of nature (due to the evolution of the shape and structure of the ear etc.) are optimal with respect to several physically realizable criteria. In this paper, we investigate the problem of defining the design constraints which when optimized yield a set of HRTF's for hearing and monaural vertical localization in an attempt to better understand, and if possible, duplicate nature's design. We pursue an engineer's design perspective and formulate a constrained optimization problem, where the desired set of HRTF's is optimized according to a cost function based on several criteria for localization, hearing and smoothness, and also by imposing physically realizable constraints on the HRTF's such as nonnegativity, energy etc. The value of the cost function for a candidate set of HRTF's is an indication of the similarity of that set of HRTF's with respect to the ideal solution (measured HRTF data). The final optimization results we present are similar to the actual HRTF's measured in human subjects, and the associated cost function values are found to be almost equal. This points to the fact that the optimization criteria defined are quite relevant. The significant outcome of this research is the identification of a relevant set of mathematical criteria that could be optimized in the human auditory system to facilitate good hearing and localization. These criteria along with the associated constraints represent the desirable characteristics of the HRTF's in an HRTF-based localization system, and could lead to a better understanding and modeling of the auditory system.     

Adaptive locks: Combining transactions and locks for efficient concurrency

Transactional memory is being advanced as an alternative to traditional lock-based synchronization for concurrent programming. Transactional memory simplifies the programming model and maximizes concurrency. At the same time, transactions can suffer from interference that causes them to often abort, from heavy overheads for memory accesses, and from expressiveness limitations (e.g., for I/O operations). In this paper we propose an adaptive locking technique that dynamically observes whether a critical section would be best executed transactionally or while holding a mutex lock. The critical new elements of our approach include the adaptivity logic and cost–benefit analysis, a low-overhead implementation of statistics collection and adaptive locking in a full C compiler, and an exposition of the effects on the programming model. In experiments with both micro and macrobenchmarks we found adaptive locks to consistently match or outperform the better of the two component mechanisms (mutexes or transactions). Compared to either mechanism alone, adaptive locks often provide 3-to-10x speedups. Additionally, adaptive locks simplify the programming model by reducing the need for fine-grained locking: with adaptive locks, the programmer can specify coarse-grained locking annotations and often achieve fine-grained locking performance due to the transactional memory mechanisms.     

Low Voltage Electrowetting-on-Dielectric Platform using Multi-Layer Insulators

A low voltage, two-level-metal, and multi-layer insulator electrowetting-on-dielectric (EWD) platform is presented. Dispensing 300pl droplets from 140nl closed on-chip reservoirs was accomplished with as little as 11.4V solely through EWD forces, and the actuation threshold voltage was 7.2V with a 1Hz voltage switching rate between electrodes. EWD devices were fabricated with a multilayer insulator consisting of 135nm sputtered tantalum pentoxide (Ta(2)O(5)) and 180nm parylene C coated with 70nm of CYTOP. Furthermore, the minimum actuation threshold voltage followed a previously published scaling model for the threshold voltage, V(T), which is proportional to (t/ε(r))(1/2), where t and ε(r) are the insulator thickness and dielectric constant respectively. Device threshold voltages are compared for several insulator thicknesses (200nm, 500nm, and 1μm), different dielectric materials (parylene C and tantalum pentoxide), and homogeneous versus heterogeneous compositions. Additionally, we used a two-level-metal fabrication process, which enables the fabrication of smaller and denser electrodes with high interconnect routing flexibility. We also have achieved low dispensing and actuation voltages for scaled devices with 30pl droplets.     

Benchmarking stereo-derived DSMs to lidar by land cover and slope for resource development in northern Ontario,Canada

Topographic and elevation data are essential in the development of supporting infrastructure around mining sites. The de facto standard for acquiring elevation data is through light detection and ranging (lidar). The high labour and monetary cost of acquiring lidar has fostered more cost-effective approaches for creating elevation models that use stereo photogrammetry. To assess the accuracy of stereo-photogrammetry-derived elevation models and their potential application, we benchmark satellite (Worldview-2) and aircraft (South Central Ontario Orthoimagery Project; SCOOP) stereo-derived digital surface models (DSMs) against a lidar-derived DSM. Our results show that both stereo-derived DSMs have strong monotonic correlations with lidar across a range of land-cover types and slopes. The overall vertical accuracy of Worldview-2 and SCOOP DSMs are similar and do not meet the United States National Digital Elevation Program (NDEP) standards. However, accuracy assessment across land-cover types and slope categories show that specific land cover types (i.e. grass, row crops/pasture, sparse vegetation and marsh) on gently sloping terrain compare well to lidar data and meet NDEP accuracy standards. We situate the presented research in the context of northern resource development and discuss opportunities to improve the vertical accuracy of stereo-derived DSMs, for example, through unmanned aerial systems.     

Dynamic behaviour of a magnetically actuated floating liquid marble

This paper reports the dynamic behaviour of a magnetically actuated floating liquid marble by analysing the oscillation of the marble. A liquid marble is a liquid droplet coated with hydrophobic powder. Magnetite particles inside the marble make it magnetic. The marble floats on a carrier liquid that contains aqueous glycerol of various concentrations. A permanent magnet located under the carrier liquid drives the floating marble with the initial velocity. Stopping the magnet abruptly causes the marble to oscillate around its final position for a few seconds. The oscillation was recorded and analysed using customised image processing and evaluation software. The damped harmonic motion model was then applied to the data and tested. Subsequently, critical parameters of the system such as the initial displacement, friction correction factor, the apparent frequency and the spring constant were determined and discussed. The simple experimental set-up and convenient theoretical approach allow us to characterise the marble motion under the influence of a magnet with good accuracy.