Studies of teratogenic effects of the dithiocarbamates maneb, mancozeb, and propineb

Oral administration of high dosages of the dithiocarbamate pesticides maneb and mancozeb was teratogenic in rats but not in mice. The malformations, severe limb and craniofacial defects, were pronounced after maneb treatment but less so after mancozeb and propineb, zinc-containing compounds. The teratogenic effect of maneb was progressively reduced by simultaneously administering increasing amounts of zinc acetate. The mechanism of the teratogenic effect may involve the compounds being chelating agents, trapping zinc required for many important enzyme systems.     

Traffic of dynamin within individual Drosophila synaptic boutons relative to compartment-specific markers

Presynaptic terminals contain several specialized compartments, which have been described by electron microscopy. We show in an identified Drosophila neuromuscular synapse that several of these compartments-synaptic vesicle clusters, presynaptic plasma membrane, presynaptic cytosol, and axonal cytoskeleton-labeled by specific reagents may be resolved from one another by laser scanning confocal microscopy. Using a panel of compartment-specific markers and Drosophila shibire(ts1) mutants to trap an intermediate stage in synaptic vesicle recycling, we have examined the localization and redistribution of dynamin within single synaptic varicosities at the larval neuromuscular junction. Our results suggest that dynamin is not a freely diffusible molecule in resting nerve terminals; rather, it appears localized to synaptic sites by association with yet uncharacterized presynaptic components. In shi(ts1) nerve terminals depleted of synaptic vesicles, dynamin is quantitatively redistributed to the plasma membrane. It is not, however, distributed uniformly over presynaptic plasmalemma; instead, fluorescence images show "hot spots" of dynamin on the plasma membrane of vesicle-depleted nerve terminals. We suggest that these dynamin-rich domains may mark the active zones for synaptic vesicle endocytosis first described at the frog neuromuscular junction.     

Effects of piracetam on the performance of rats in a delayed match-to-position task

The growing use of antibody-based separation methods has paralleled the expansion of immunochemical detection methods in moving beyond the clinical diagnostic field to applications in environmental monitoring. In recent years high-performance immunoaffinity chromatography, which began as a separation technique in biochemical and clinical research, has been adapted for separating and quantifying environmental pollutants. Bioaffinity offers a selective biological basis for separation that can be incorporated into a modular analytical process for more efficient environmental analysis. The use of immunoaffinity chromatography for separation complements the use of immunoassay for detection. A widely used immunochemical detection method for environmental analyses is enzyme immunoassay. The objective of this paper is to review the status of bioaffinity-based analytical procedures for environmental applications and human exposure assessment studies. Environmental methods based on bioaffinity range from mature immunoassays to emerging techniques such as immunosensors and immunoaffinity chromatography procedures for small molecules.     

Spin injection in n-type resonant tunneling diodes

We have studied the polarized resolved photoluminescence of n-type GaAs/AlAs/GaAlAs resonant tunneling diodes under magnetic field parallel to the tunnel current. Under resonant tunneling conditions, we have observed two emission lines attributed to neutral (X) and negatively charged excitons (X⁻). We have observed a voltage-controlled circular polarization degree from the quantum well emission for both lines, with values up to −88% at 15 T at low voltages which are ascribed to an efficient spin injection from the 2D gases formed at the accumulation layers.     

Algorithm substitution attacks against receivers

This work describes a class of Algorithm Substitution Attack (ASA) generically targeting the receiver of a communication between two parties. Our work provides a unified framework that applies to any scheme where a secret key is held by the receiver; in particular, message authentication schemes (MACs), authenticated encryption (AEAD) and public key encryption (PKE). Our unified framework brings together prior work targeting MAC schemes (FSE’19) and AEAD schemes (IMACC’19); we extend prior work by showing that public key encryption may also be targeted. ASAs were initially introduced by Bellare, Paterson and Rogaway in light of revelations concerning mass surveillance, as a novel attack class against the confidentiality of encryption schemes. Such an attack replaces one or more of the regular scheme algorithms with a subverted version that aims to reveal information to an adversary (engaged in mass surveillance), while remaining undetected by users. Previous work looking at ASAs against encryption schemes can be divided into two groups. ASAs against PKE schemes target key generation by creating subverted public keys that allow an adversary to recover the secret key. ASAs against symmetric encryption target the encryption algorithm and leak information through a subliminal channel in the ciphertexts. We present a new class of attack that targets the decryption algorithm of an encryption scheme for symmetric encryption and public key encryption, or the verification algorithm for an authentication scheme. We present a generic framework for subverting a cryptographic scheme between a sender and receiver, and show how a decryption oracle allows a subverter to create a subliminal channel which can be used to leak secret keys. We then show that the generic framework can be applied to authenticated encryption with associated data, message authentication schemes, public key encryption and KEM/DEM constructions. We consider practical considerations and specific conditions that apply for particular schemes, strengthening the generic approach. Furthermore, we show how the hybrid subversion of key generation and decryption algorithms can be used to amplify the effectiveness of our decryption attack. We argue that this attack represents an attractive opportunity for a mass surveillance adversary. Our work serves to refine the ASA model and contributes to a series of papers that raises awareness and understanding about what is possible with ASAs.