DECODE: a new method for discovering clusters of different densities in spatial data

When clusters with different densities and noise lie in a spatial point set, the major obstacle to classifying these data is the determination of the thresholds for classification, which may form a series of bins for allocating each point to different clusters. Much of the previous work has adopted a model-based approach, but is either incapable of estimating the thresholds in an automatic way, or limited to only two point processes, i.e. noise and clusters with the same density. In this paper, we present a new density-based cluster method (DECODE), in which a spatial data set is presumed to consist of different point processes and clusters with different densities belong to different point processes. DECODE is based upon a reversible jump Markov Chain Monte Carlo (MCMC) strategy and divided into three steps. The first step is to map each point in the data to its mth nearest distance, which is referred to as the distance between a point and its mth nearest neighbor. In the second step, classification thresholds are determined via a reversible jump MCMC strategy. In the third step, clusters are formed by spatially connecting the points whose mth nearest distances fall into a particular bin defined by the thresholds. Four experiments, including two simulated data sets and two seismic data sets, are used to evaluate the algorithm. Results on simulated data show that our approach is capable of discovering the clusters automatically. Results on seismic data suggest that the clustered earthquakes, identified by DECODE, either imply the epicenters of forthcoming strong earthquakes or indicate the areas with the most intensive seismicity, this is consistent with the tectonic states and estimated stress distribution in the associated areas. The comparison between DECODE and other state-of-the-art methods, such as DBSCAN, OPTICS and Wavelet Cluster, illustrates the contribution of our approach: although DECODE can be computationally expensive, it is capable of identifying the number of point processes and simultaneously estimating the classification thresholds with little prior knowledge.     

Risk of benzene-induced leukemia: a sensitivity analysis of the pliofilm cohort with additional follow-up and new exposure estimates

This report updates the risk assessment by Crump and Allen (1984) for benzene-induced leukemia that was used by OSHA (1987) to support its reduction of the permissible exposure limit (PEL) to 1 ppm and that also was the basis for EPA's (1985) interim "unit risk" for benzene. The present study derives new risk estimates using data from follow-up through 1987 (whereas the earlier assessment only had follow-up available through 1978), and using new exposure estimates for this cohort developed by Paustenbach et al. (1992) that account for a number of factors that were unknown or not fully evaluated in earlier exposure assessments. There was a significant excess of acute myelocytic or acute monocytic leukemia (AMML, the only forms of acute nonlymphatic leukemia observed) in this cohort, and this end point also exhibited a strong dose-response trend. AMML was the only hematopoietic or lymphatic cancer that was clearly linked to benzene exposure. However, quantitative estimates of risk based on modeling either AMML or all leukemia differed by only 20%. Differences between the two Pliofilm plant locations in the occurrence of AMML were not statistically significant (.12 < or = p < or = .21) after differences in levels of benzene exposure were taken into account. The Paustenbach et al. exposures predicted a quadratic dose response, based on a measure of exposure that weighted intensity of exposure more heavily than duration of exposure. The best-fitting quadratic models predicted an additional lifetime risk of a benzene-related death from 45 yr of exposure to 1 ppm of between 0.020 and 0.036 per thousand. Statistical confidence intervals (90%) on these estimates were barely wide enough to include risk estimates based on linear dose response models. These linear models predicted risks of between 1.6 and 3.1 per thousand.     

Interaction of transport resistances with biochemical reaction in packed-bed solid-state fermentors: effect of temperature gradients

Subdermal superficial liposuction, first presented by the authors at the ISAPS Congress at Zurich in 1989, is performed with thin three-hole Mercedes cannulas (diameter ranges from 1.8 to 2 mm) to treat small and secondary adiposities and to allow better skin retraction. Suction of the subdermal layer of fat reduces the thickness and consistency of the superficial fat and enhances the possibility of skin retraction. In cases where there is a large adiposity of the abdomen, arms, or inner thighs, there is a conspicuous volume of fat whose weight tends to overstretch and to carry the overlying skin downward. In these cases we need to reduce the large fat volume to permit effective skin retraction. Therefore, we apply the principles of traditional liposuction with those of subdermal superficial liposuction to aspirate large amounts of fat from all the adipose layers. We call this technique Massive All Layer Liposuction (MALL). The amount of skin shrinkage after this "defatting" procedure is remarkable and the clinical results are very good. The MALL technique can be applied to other areas as well. In our experience this new liposuction technique has dramatically reduced the indications of abdominoplasties and dermolipectomies of inner thighs and arms.     

Epidemiology and ethics: the perspective of the Third World

The relation of epidemiology and ethics is discussed from a Third World perspective, including the following issues: the structure and dynamics of a Third World Society; the nature of the relationship between the First World "islanders" in the Third World and their counterparts in the First World, and between the "islanders" and their fellow citizens; the inner dynamics of Third World researchers; the different knowledge systems; and the role of institutions in the Third World and the First World.     

The effects of β-alumina on the production of Al2O3/Al composites by the directed melt oxidation process

Directed melt oxidation (DMOX) of pure aluminium has been used to produce Al/Al₂O₃ composites by growth into a particulate alumina filler in the absence of any dopants apart from a -Al₂O₃ impurity in the filler. The microstructural development and mechanisms of growth of these composites have been investigated. It is shown that the Al₂O₃ filler used in this work has both chemical and physical effects on the reaction process. The -Al₂O₃ impurity introduces sodium into the system; this increases the wettability of alumina (both filler and oxidation reaction product) by molten aluminium, and initiates DMOX reactions. In addition, the filler particle size has an effect on the directed oxidation reaction. If the particle size is too fine, no oxidation growth takes place. Filler particles limit the ingress of oxygen through the reaction front so that AIN instead of Al₂O₃ may be formed in regions behind the main reaction front. Although such AIN production is seen when magnesium is used as a dopant to initiate DMOX reactions in the Al/Al₂O₃ system, it is more marked with sodium, because the latter has a greater effect on the wettability of alumina by aluminium.     

Evolution of gypsy-group retrotransposons: phylogenetic analysis of domains included in the pol-polyprotein

Transposons of gypsy group are assigned to LTR-containing retrotransposons present in the genomes of invertebrates, fungi, and plants. In this work, a theoretical analysis of the potential products of ORFs of these retrotranposons was conducted. Alignments were obtained and trees of similarity were constructed for domains of the POL region. On the basis of the obtained data, two hypothetically monophyletic subgroups of transposons were distinguished within the framework of the gypsy group, settling the genomes of taxonomically related organisms (the subgroup of "true" gypsy of insects and the subgroup of gypsy-like transposons of plants and fungi). A number of peculiarities of the topology of these trees hypothetically indicate cases of genetic conversion and recombination of domains accompanying the evolution of this group. The amino acid substitution fixation rate was evaluated on the basis of comparison of sequences of the protein products of ORFs. Estimates of the time of divergence of subgroups of gypsy-group transposons are significantly less than estimates of the times of divergence of their host species. One explanation for this discrepancy might be the hypothesis of settlement by transposons of the genomes of isolated host species.     

Protein kinase C modulates estrogen receptors in differentiated osteoblastic cells in vitro

Ventriculo-peritoneal shunts (VPS) are the most frequent operative procedures used to treat hydrocephalic children. Abdominal complications of VPS are now a rare event; however, their frequency varies from 5% to 47% according to reports. Anything that causes an obstruction or impediment of the VP derivation system will lead to intracranial hypertension, which requires immediate surgery. From 1985 to 1995 at the Division of Pediatric Surgery of the Federico II University of Naples, ten laparoscopies were performed in ten children with VPS complications. Cerebrospinal fluid pseudocysts were found in four infants. There was one case of abdominal wall perforation by the tip of the catheter at the umbilical level, two bowel obstructions, and one catheter was lost in the abdominal cavity. Finally, two children had malfunctioning of the peritoneal limb of the catheter. The laparoscopic technique was curative in all ten cases, thus avoiding a conventional laparotomy and the consequent risk of adhesions, which could cause further complications.     

Some sexological characteristics of stress incontinent women

The goal of stress incontinence surgery is to prevent opening of the urethra during increases in intra-abdominal pressure. Greater refinements in the understanding of the pathophysiology of incontinence and experience with newer treatments have extended surgical thinking beyond the familiar paradigm "to place the urethra in a high retropubic position." When incontinence is associated with vaginal hypermobility, vaginal support may be sufficient to restore continence if the suburethral vaginal wall is sufficiently strong, an evaluation which must often be made by physical examination alone. However, when the vaginal wall is weak, the urethra will require an alternative form of support, usually a sling. If the urethra is intrinsically deficient, vaginal support may not be sufficient to prevent opening during increased intra-abdominal pressure, and coaptation by sling obstruction or periurethral bulking injection may be required. Most laparoscopic approaches to stress incontinence use Burch's method, which offers excellent urethral stability provided the suburethral vaginal wall is strong. Newer insights into the relation between vaginal mobility and urethral closure are discussed, as well as anatomic aspects of the Burch suspension relevant to laparoscopic repair.     

Transient temperature responses of hydronic radiant floor heating system by different pipe embedding depth and water supply condition

"Ondol" is a Korean unique heating system. It is a specific radiant floor heating system using combustion heat of briquette or timber in Korea. Such traditional "Ondol" is changed to radiant heating system with pipe-coil embedded in the floor or slab. This study has contributed to the understandings of the transient behaviours of Ondol-heated floor panels and enclosure exposed to this type of heating system. The result is that the water supply temperature had a large effect on the rate of increase in floor surface and room air temperature. But, in spite of a higher water supply temperature, the heat flow rate was not increased considerably. The shallow pipe embedding depths, of course, result in a low heat flow rate.     

Corneal topography of photorefractive keratectomy versus laser in situ keratomileusis. Summit PRK-LASIK Study Group

OBJECTIVE: This study aimed to compare qualitative patterns of corneal topography early in the postoperative course after excimer laser photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) when used for the treatment of myopia of 6.0 to 15.0 diopters. DESIGN: The study design was a prospective, multicenter, randomized clinical trial. PARTICIPANTS: A total of 64 eyes were treated with PRK and 54 eyes were treated with LASIK. INTERVENTION: Using the Summit Apex excimer laser, patients received either PRK or LASIK using a single pass, multizone excimer laser ablation. Computer-assisted videokeratography was performed at designated postoperative examinations. MAIN OUTCOME MEASURES: Videokeratography maps at 1 and 3 months after surgery were classified using a standard classification scheme. The association of topography patterns to loss of spectacle-corrected visual acuity was tested. RESULTS: At 1 month, for the PRK (n = 60) and LASIK (n = 51) groups, respectively, 63.3% and 19.6% of eyes fell into one of the four optically irregular groups (central island, keyhole, semicircular, or irregularly irregular; P < 0.001). At 3 months, for the PRK (n = 49) and LASIK (n = 39) groups, respectively, 36.7% and 10.3% of eyes fell into one of the optically irregular groups (P = 0.004). Comparing the 1- and 3-month examination results in the PRK and LASIK groups, respectively, 19 (42%) of 45 eyes and 11 (31%) of 36 eyes had a change in topography, generally to an optically smoother pattern. The irregular groups, taken together, were associated with a greater tendency toward loss of spectacle-corrected visual acuity of two or more Snellen lines (P = 0.01). There also was greater tendency toward loss of spectacle-corrected visual acuity in the PRK group that diminished with time (P < 0.01 at 1 month, P = 0.05 at 3 months). CONCLUSIONS: After treatment for moderate-to-high myopia, LASIK topography patterns generally are more regular than are PRK patterns. This may be a result either of masking of underlying topography perturbations by the lamellar corneal flap, thus mitigating induced topography changes, or differences in surface wound healing. This study suggests that more rapid return of spectacle-corrected visual acuity found in patients treated with LASIK may be a result of more regular topography patterns early in the postoperative course.