Empirically supported treatments: Implications for training.

This article discusses the role of empirically supported treatments (ESTs) in the training of clinical psychologists. Training in ESTs can be integrated in ways that vary depending on the level of training and setting. Predoctoral programs, internships, postdoctoral programs, and continuing education are discussed in regard to special challenges and sequencing of training. A preliminary set of guidelines for training in ESTs is suggested. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Predatory behavior in laboratory mice: Strain and sex comparisons.

Measured latency to attack live crickets in 26 male and 26 female naive, non-food-deprived laboratory mice from a genetically heterogenous stock (HS/Ibg) and in 7 inbred strains (10 male and 10 female Ss for each strain). The HS/Ibg, Is/Crgl, C57BL/Crgl, and C3H/Crgl Ss had the shortest latencies to attack crickets. The RIII/Crgl and BALB/cCrgl Ss were intermediate, while DBA/2Crgl and A/Crgl were slowest. Among the inbred strains sex differences were nonexistent or inconsistent from strain to strain. However, HS/Ibg males were more likely to attack than were females. Enough females attack for cricket killing to be a useful form of attack behavior for genetic experiments. In nearly all Ss latency decreased from the 1st to the 2nd trial, indicating that cricket killing is rapidly learned in adult mice of a wide variety of genotypes. (16 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Too stressed out to participate? Examining the relation between stressors and survey response behavior.

Despite the use of survey-based organizational data in many studies of organizational behavior, survey response behavior and nonresponse are rarely studied phenomena. This study expands on previously proposed survey response and nonresponse frameworks by integrating the job stress literature. The authors investigated whether overload, role ambiguity, and role conflict experienced by individuals relate to survey response behavior. Using organizational citizenship behavior theory and social exchange theory as theoretical frameworks, the authors proposed that nonrespondents experience higher levels of stressors than respondents. Data collected in a longitudinal field study partially supported the hypotheses. As hypothesized, overload increased the likelihood of nonresponse. Contrary to hypotheses, role ambiguity decreased the likelihood of nonresponse. Role conflict was not significantly related to nonresponse. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Assessing and interpreting personality change and continuity in patients treated for major depression.

Structural, mean- and individual-level, differential, and ipsative personality continuity were examined in 599 patients treated for major depression assigned to 1 of 6 forms of a 6-month pharmaco-psychotherapy program. Covariation among traits from the Five Factor model remained invariant across treatment, and patients described themselves as slightly more extraverted, open to experience, agreeable and conscientious, and substantially more emotional stable after treatment. Trait changes were only to a small extent explained by changes in depression severity. There was evidence for differential, individual-level, and ipsative stability, with stable personality profiles in terms of shape and to a lesser extent in terms of scatter and elevation. Traits remain relatively stable, except for emotional stability, despite the depressive state and the psychopharmacological interventions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Stereodivergent Biocatalytic Formal Reduction of α-Angelica Lactone to (R)- and (S)-γ-Valerolactone in a One-Pot Cascade

The formal asymmetric and stereodivergent enzymatic reduction of α-angelica lactone to both enantiomers of γ-valerolactone was achieved in a one-pot cascade by uniting the promiscuous stereoselective isomerization activity of Old Yellow Enzymes with their native reductase activity. In addition to running the cascade with one enzyme for each catalytic step, a bifunctional isomerase-reductase biocatalyst was designed by fusing two Old Yellow Enzymes, thereby generating an unprecedented case of an artificial enzyme catalyzing the reduction of nonactivated C=C bonds to access (R)-valerolactone in overall 41 % conversion and up to 91 % ee. The enzyme BfOYE4 could be used as single biocatalyst for both steps and delivered (S)-valerolactone in up to 84 % ee and 41 % overall conversion. The reducing equivalents were provided by a nicotinamide recycling system based on formate and formate dehydrogenase, added in a second step. This enzymatic system provides an asymmetric route to valuable chiral building blocks from an abundant bio-based chemical.     

A new correlation for the coefficient of restitution of particles with low mechanical resistance for modeling wastewater treatment biofilm reactors

Clean Technologies and Environmental Policy - Fluidized bed bioreactors are widely used in wastewater treatment applications. Such reactors employ gel beads or hard particles covered with a biofilm...     

Histological Evaluation and Gene Expression Profiling of Autophagy-Related Genes for Cartilage of Young and Senescent Rats

Autophagy is a cellular mechanism that protects cells from stress by digesting non-functional cellular components. In the cartilage, chondrocytes depend on autophagy as a principal mechanism to maintain cellular homeostasis. This protective role diminishes prior to the structural damage that normally occurs during aging. Considering that aging is the main risk factor for osteoarthritis, evaluating the expression of genes associated with autophagy in senescent cartilage might allow for the identification of potential therapeutic targets for treatment. Thus, we studied two groups of young and senescent rats. A histological analysis of cartilage and gene expression quantification for autophagy-related genes were performed. In aged cartilage, morphological changes were observed, such as an increase in cartilage degeneration as measured by the modified Mankin score, a decrease in the number of chondrocytes and collagen II (Col2a1), and an increase in matrix metalloproteinase 13 (Mmp13). Moreover, 84 genes associated with autophagy were evaluated by a PCR array analysis, and 15 of them were found to be significantly decreased with aging. Furthermore, an in silico analysis based on by two different bioinformatics software tools revealed that several processes including cellular homeostasis, autophagosome assembly, and aging—as well as several biological pathways such as autophagy, insulin-like growth factor 1 (IGF-1) signaling, PI3K (phosphoinositide 3-kinase)/AKT (serine/threonine kinase) signaling, and mammalian target of rapamycin (mTOR) signaling—were enriched. In conclusion, the analysis identified some potential targets for osteoarthritis treatment that would allow for the development of new therapeutic strategies for this chronic disease.     

Radiomics and Machine Learning in Oral Healthcare

The increasing storage of information, data, and forms of knowledge has led to the development of new technologies that can help to accomplish complex tasks in different areas, such as in dentistry. In this context, the role of computational methods, such as radiomics and Artificial Intelligence (AI) applications, has been progressing remarkably for dentomaxillofacial radiology (DMFR). These tools bring new perspectives for diagnosis, classification, and prediction of oral diseases, treatment planning, and for the evaluation and prediction of outcomes, minimizing the possibilities of human errors. A comprehensive review of the state‐of‐the‐art of using radiomics and machine learning (ML) for imaging in oral healthcare is presented in this paper. Although the number of published studies is still relatively low, the preliminary results are very promising and in a near future, an augmented dentomaxillofacial radiology (ADMFR) will combine the use of radiomics‐based and AI‐based analyses with the radiologist's evaluation. In addition to the opportunities and possibilities, some challenges and limitations have also been discussed for further investigations.