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排序方式: 共有583条查询结果,搜索用时 15 毫秒
561.
Dominik Horny Joél Schukraft Carolin Pieper Kay André Weidenmann Katrin Schulz 《Advanced Engineering Materials》2023,25(19):2300259
An interpenetrating metal ceramic composite (IMCC) has been investigated regarding the potential as well as the feasibility of self-healing. Triggered by heating, cracks in the damaged composite located mainly in the Al2O3 ceramic or at the interface could be filled and closed by the liquid AlSi10Mg metal alloy. This healing procedure promises to reduce stress concentrations at crack tips and to improve the mechanical properties compared to the predamaged composite. Two different numerical approaches have been introduced to investigate this assumption and the potential of self-healed IMCCs for a best case scenario: 1) A simple 2D model to analyze the reduction of stress concentrations in front of a crack tip within the ceramic due to healing and 2) a 3D model based on CT-scan reconstructed microstructures to study how macroscopic mechanical properties can be restored depending on the amount of predamage. Further, the self-healing approach has been investigated experimentally for the same composite. Despite the fact that experimental self-healing of the investigated IMCC is only moderately feasible so far, the study shows the great potential that can still be exploited in order to extend the service life time of IMCC engineering components. 相似文献
562.
Thomas Hamacher Matthias Huber Johannes Dorfner Katrin Schaber Alex M. Bradshaw 《Fusion Engineering and Design》2013,88(6-8):657-660
Nuclear fusion can be considered as a base-load power plant technology: High investment costs and limited operational flexibility require continuous operation. Wind and solar, on the other hand, as the putative main pillars of a future renewable energy system, are intermittent power sources. The resulting variations that occur on many different time scales require at first sight a rather flexible back-up system to balance this stochastic behavior. Fusion would appear not to be well suited for this task. The situation changes, however, if a large-scale renewable energy system is envisaged based on a transnational, or even transcontinental power grid. The present paper discusses a possible European power system in the year 2050 and beyond. A high percentage share of renewable energies and a strong power grid spanning the whole of Europe and involving neighboring countries, in particular those in North Africa, are assumed. The linear programming model URBS is used to describe the power system. The model optimizes the overall system costs and simulates power plant operation with an hourly resolution for one whole year. The geographical resolution is at least at the country level. The renewable technologies are modeled first on a more local level and then summed together at the country or regional level. The results indicate that the smoothing effects of the large-scale power grid transform the intermittent renewable supply, which is then more compatible with base-load power plants such as fusion reactors. 相似文献
563.
Dr. Torsten Sehl Lisa Seibt Katrin Kappauf Pia Ergezinger Jan-Dirk Spöring Kristina Mielke Moritz Doeker Dr. Neha Verma Dr. Marco Bocola Dr. Thomas Daußmann Dr. Haibin Chen Shumin Shi Prof. Dr. Andreas Jupke Prof. Dr. Dörte Rother 《化学,工程师,技术》2023,95(4):557-564
(2R,4R)-Pentanediol is an interesting precursor for the synthesis of chiral ligands. A ketoreductase (KRED) was employed for the asymmetric reduction of acetylacetone to this diol. Biocatalysis often suffers from low concentrations of hydrophobic substrates and low stability of the enzyme in unconventional media. Here, we present an engineered KRED variant applicable in a neat substrate system, including upscaling to the multi-liter scale and downstream processing (DSP). Our engineered KRED applied in a neat substrate system is a powerful technique for the synthesis of chiral diols yielding product concentrations of 208 g L−1. 相似文献
564.
565.
Schaefer K Albers J Sindhuwinata N Peters T Meyer B 《Chembiochem : a European journal of chemical biology》2012,13(3):443-450
Glycosyltransferases play an important role in the formation of oligosaccharides and glycoconjugates. To find suitable and selective inhibitors for this class of enzymes is still challenging. Here, we describe a novel concept that allows the design of inhibitors based on the structure of the donor substrate binding pocket. As a first step we describe the design, synthesis and analysis of inhibitors of the human blood group B galactosyltransferase (GTB). This enzyme served as a model system to study the concept, which can be used for easy access of glycosyltransferase inhibitors in general. In silico docking of bicyclic heteroaromatic ligands to GTB and experimental verification of binding affinities by saturation transfer difference NMR (STD NMR) spectroscopy gave 9-N-pentityl uric acid derivatives as non-ionic mimics of UDP. Two derivatives were synthesized and showed inhibitory activity for GTB as determined by competitive STD NMR experiments and by a radiolabeled enzyme assay. 相似文献
566.
567.
This work reports on a considerable resolution improvement of micro/nanostencil lithography when applied on full-wafer scale by using compliant membranes to reduce gap-induced pattern blurring. Silicon nitride (SiN) membranes are mechanically decoupled from a rigid silicon (Si) frame by means of four compliant, protruding cantilevers. When pressing the stencil into contact with a surface to be patterned, the membranes thus adapt to the surface independently and reduce the gap between the membrane and the substrate even over large, uneven surfaces. Finite element modeling (FEM) simulations show that compliant membranes can deflect vertically 40 μm which is a typical maximal non-planarity observed in standard Si wafers, due to polishing. Microapertures in the stencil membrane are defined by UV lithography and nanoapertures, down to 200 nm in diameter, using focused ion beam (FIB). A thin aluminium (Al) layer is deposited through both compliant and non-compliant membranes on a Si wafer, for comparison. The blurring in the case of compliant membranes is up to 95% reduced on full-wafer scale compared to standard (non-compliant) membranes. 相似文献
568.
Frank-Dieter Kopinke Robert K?hler Katrin Mackenzie Helko Borsdorf Christoph Schüth 《Grundwasser》2002,14(1):140-145
Im Rahmen des Forschungsverbundes SAFIRA wurden zwei neue Katalysatorsysteme zur reduktiven Dehalogenierung von CKW mit H2 entwickelt und am Standort Bitterfeld in Grundwasser-Durchflussreaktoren untersucht. Die katalytisch aktive Komponente Pd wurde zum Schutz vor Vergiftung durch ionische Verbindungen zum einen in hydrophobe Polymermembranen eingebettet, zum anderen wurden Pd-Cluster in den Poren hydrophober Zeolithe erzeugt. Die erreichten Standzeiten beider Katalysatoren waren trotzdem bedingt durch die Bildung von H 2 S und organischen Schwefelverbindungen durch mikrobiologische Sulfatreduktion gering. Die Katalysatoren waren zwar durch eine Spülung mit Hypochlorit regenerierbar, unterlagen aber nach wenigen Tagen erneuter Vergiftung. Der Einsatz von Pd-Katalysatoren unter Bitterfelder Grundwasserbedingungen wird deshalb als problematisch eingesch?tzt. 相似文献
569.
Ortega F Sameith K Turan N Compton R Trevino V Vannucci M Falciani F 《Philosophical transactions. Series A, Mathematical, physical, and engineering sciences》2008,366(1878):3067-3089
An important area of research in systems biology involves the analysis and integration of genome-wide functional datasets. In this context, a major goal is the identification of a putative molecular network controlling physiological response from experimental data. With very fragmentary mechanistic information, this is a challenging task. A number of methods have been developed, each one with the potential to address an aspect of the problem. Here, we review some of the most widely used methodologies and report new results in support of the usefulness of modularization and other modelling techniques in identifying components of the molecular networks that are predictive of physiological response. We also discuss how system identification in biology could be approached, using a combination of methodologies that aim to reconstruct the relationship between molecular pathways and physiology at different levels of the organizational complexity of the molecular network. 相似文献
570.
Perruchon J Ortmann R Altenkämper M Silber K Wiesner J Jomaa H Klebe G Schlitzer M 《ChemMedChem》2008,3(8):1232-1241
Fosmidomycin and its homologue FR900098 are inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, which is part of the mevalonate-independent isoprenoid biosynthetic pathway. Replacement of the phosphonate moiety by uncharged sulfone or sulfonamide partial structures resulted in complete loss of activity. Dropping one of the two negative charges resulted in a marked decrease in activity. Through occupation of a hydrophobic binding site, some activity could be regained, leading to compounds with micromolar activity against cultured malaria parasites. 相似文献