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31.
AJ Conrad EY Chiang LE Andeen C Avolio SM Walker RW Baumhefner R Mirzayan WW Tourtellotte 《Canadian Metallurgical Quarterly》1994,54(1-2):99-108
A method for quantitating specific anti-viral antibodies in serum and cerebrospinal fluid (CSF) is established using enzyme-linked immunosorbent assay (ELISA). Quantitated antibody levels are used to determine intrathecal specific IgG synthesis rate for the particular antibody. Measles virus was used as a model for validating this quantitative technique: a mutated form of measles virus is a cause of subacute sclerosing panencephalitis (SSPE) and there is a possibility that measles virus is related to the cause of multiple sclerosis (MS). Matched serum and CSF samples were assayed. Concentration of anti-measles IgG was determined and intrathecal measles-specific IgG synthesis rate was calculated. For the SSPE samples, measles-specific IgG synthesis rate was elevated and comprised > 20% of the total intrathecal IgG synthesis rate; these results are consistent with the literature. The ELISA method can be performed routinely, providing a quick, simple, reproducible means of quantitating specific antibody concentrations, with sensitivity greater than 1 nanogram per milliliter. With this method, quantitation of IgG antibodies to any other viral antigen can be reliably and precisely determined. 相似文献
32.
M Tolnay A Probst AU Monsch HB Staehelin R Egensperger 《Canadian Metallurgical Quarterly》1998,96(3):225-227
Glanzmann's thrombasthenia is a rare inherited hematological disorder defined by deficiency or abnormality of the glycoprotein (GP) IIb-IIIa complex. Presenting symptoms are hemorrhagic events, mainly epistaxis, purpura, or menorrhagia. We describe the clinical course and management of a 14-year-old girl with Glanzmann's thrombasthenia and severe menorrhagia. Following treatment with 20 U of packed red blood cells, 37 U of platelets, 7 U of fresh frozen plasma, cryoprecipitate, intravenous estrogens, and methylergotrine maleate with no improvement, the uterine cavity was packed for 48 hr. This unusual procedure halted the bleeding and avoided the necessity for a hysterectomy. When treating acute menorrhagia in patients with Glanzmann's thrombasthenia, the physician should be familiar with the characteristics and all treatment modalities for this disorder. 相似文献
33.
Nonsense codons between position 14 within the first exon and position 193 within the penultimate exon of the human gene for triosephosphate isomerase reduce mRNA abundance to 25% of normal. The reduction in abundance is due to the decay of newly synthesized mRNA that copurifies with nuclei. TPI mRNA that copurifies with cytoplasm is immune to decay. We show here that immunity is not due to the failure of nonsense-containing mRNA to form polysomes. This finding indicates that cytoplasmic mRNA, in contrast to nucleus-associated mRNA, may have lost one or more factors that are required for nonsense-mediated decay or gained one or more factors that confer immunity to nonsense-mediated decay. 相似文献
34.
LE B?ttiger 《Canadian Metallurgical Quarterly》1994,91(28-29):2699-2700
35.
为了满足工程建设日益大型化的发展,两台以及多台起重机共同作业的需求日益增强。设定了起重机双机协同模型,使用飞思忙尔MC9S12DGl28单片机以实现起重机监控器的双机协同功能,设计了CAN总线节点模块来实现双机的数据采集、状态检测和故障处理等功能,给出了实现双机协同的硬件设计和软件流程图。系统在实际运行过程中稳定、可靠,能保证起重机在双机协同时做到步调一致,并很好地应对故障的发生,同时表明CAN总线在起重机工作环境中能够很好地发挥自身通讯距离长、抗干扰能力强等优势,符合了双机协同的功能要求。 相似文献
36.
Martin Gneiser Julia Heidemann Mathias Klier Andrea Landherr Florian Probst 《Information Systems and E-Business Management》2012,10(1):61-84
Online social networks have been gaining increasing economic importance in light of the rising number of their users. Numerous
recent acquisitions priced at enormous amounts have illustrated this development and revealed the need for adequate business
valuation models. The value of an online social network is largely determined by the value of its users, the relationships
between these users, and the resulting network effects. Therefore, the interconnectedness of a user within the network has
to be considered explicitly to get a reasonable estimate for its economic value. Established standard business valuation models,
however, do not account for these aspects sufficiently. Thus, we propose an economic model for the valuation of online social
networks, which takes into account the users’ interconnectedness within the network. Furthermore, we analyze different centrality
measures, which can be used to quantify users’ interconnectedness in online social networks and propose a measure which is
based on the PageRank-algorithm. Finally, the practical application of the model is illustrated by an example of the European
online social network XING.com. 相似文献
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较详细的介绍了机械式轮胎定型硫化机在生产过程中所遇上的各种常见故障并进行了分析,提出了解决方案。 相似文献
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