Linearized method: A new approach for kinetic analysis of central dopamine D(2) receptor specific binding

We proposed a new method (;linearized method') to analyze neuroleptic ligand-receptor specific binding in a human brain using positron emission tomography (PET). We derived the linear equation to solve four rate constants, k(3), k(4), k(5), k(6) from PET data. This method does not demand a radioactivity curve in plasma as an input function to the brain, and can perform fast calculations in order to determine rate constants. We also tested the nonlinearized method including nonlinear equations which is a conventional analysis using plasma radioactivity corrected for ligand metabolites as an input function. We applied these methods to evaluate dopamine D(2) receptor specific binding of [(11)C] YM-09151-2. The value of B(max)/K(d)=k(3)/k (4) obtained by the linearized method was 5.72+/-3.1 which was consistent with the value of 5.78+/-3.4 obtained by the nonlinearized method.     

A simple equivalent circuit for interdigital transducers based on the coupled-mode approach

The coupled-mode approach is a powerful tool for analyzing surface acoustic wave (SAW) periodic structures such as reflectors and interdigital transducers. The relations among the terminal quantities at two acoustical ports and one electrical port of an interdigital transducer (IDT) are derived from coupled-mode equations. A simple distributed-parameter equivalent circuit representing the entire IDT is proposed. A few examples of applications of this equivalent circuit to analysis of SAW devices are presented.     

An electrostatic microactuator using LIGA process for a magnetic head tracking system of hard disk drives

 We demonstrate an electrostatic micro actuator which is fabricated by LIGA process. The actuator is designed for a magnetic head tracking system of hard disk drives (HDDs). The actuator is essential to achieve very high track density of HDDs. We realize the aspect ratio of 125 by the LIGA process using a Si-Au mask. We propose to use PMMA molds both as the mechanical structure and as the insulator between electrodes. We believe there are great opportunity for the LIGA process in making micro actuators of HDDs. Received: 25 August 1997 / Accepted: 24 October 1997     

BMDP program for piecewise linear regression

Piecewise linear regression has potentially broad applications in medical data analysis as well as other types of regression. Various kinds of algorithms have been proposed for finding optimum piecewise linear regressions. This paper presents a BMDP program for obtaining near optimum piecewise linear regression equations. An idea intrinsic to the method is that restricting parameter space to a discrete set makes the difficult problems become standard problems. Any software having the variable selection feature in the multiple linear regression can be used to apply the method.     

An Improved Method for the Preparation of Schardinger β-Dextrin on a Industrial Scale by Cyclodextrin Glycosyl Transferase of an Alkalophilic Bacillus Sp. (ATCC 21783)

The formation of Schardinger ß-dextrin from starch by an alkalophilic Bacillus sp. (ATCC 21783) has been studied. Factors affecting the yield of cyclodextrins include the type, concentration, and dispersion of the starch; the time of the enzymolysis, the amount of enzyme used. A method for the preparation of Schardinger ß-dextrin on a industrial scale without using precipitants was devised. The final yield of ß-cyclodextrin was 3.6 kg from 15 kg of potato starch.     

Effect of annealing conditions on the uniformity of undoped Semi-Insulating InP

Recently, it was found that undoped semi-insulating InP can be obtained by highpressure annealing of high purity materials. The reproducibility and the uniformity was, however, not satisfactory. In the present work, we found that not only Fe concentrations but also Cr and Ni concentrations in annealed wafers were slightly increased during annealing. Since it seems that the origin of the contamination was due to the vapor source of red phosphorus, conductive InP with a trace amount of Fe was annealed under low phosphorus vapor pressure in order to reduce the contamination. By preventing the contamination of Cr and Ni, preparation of semi-insulating InP became highly reproducible. The minimum Fe concentration for realizing semi-insulating InP was found to be 1 x 10¹⁵cm⁻³. It was also found that the better resistivity uniformity can be obtained at higher annealing temperatures.     

Properties of Starch Films and their Improvement

The tensile strengths and elongations of starch films prepared from various unmodified and modified starches were measured. These properties were improved by addition of urea and polyvinyl alcohol to the starch paste. The results obtained were as follows.

• 1 The heating temperature greatly affected the tensile strength and elongation of various unmodified starches. Potato starch gave the best film.
• 2 Introduction of hydroxyethyl groups into corn starch had unexpectedly little affect on the properties of the films.
• 3 A combination of hydroxyethylation and acid-modification slightly improved the properties of the films.
• 4 No film could be obtained after combinations of hydroxyethylation and hypochlorite-oxidation, pyrodextrinization or α-amylase-dextrinization. However, addition of urea to these modified starches resulted in good films.
• 5 On addition of urea the elongation of starch films increased and the pastes adhered uniformly to water repellent surfaces.
• 6 A film with the best properties was prepared from a mixture of 67% acid-modified hydroxyethyl starch, 13% urea and 20% polyvinyl alcohol.

     

Studies on the Structure of Leguminosae Starches. 1. Solubility in Dimethyl Sulfoxide and by Enzymatic Action

In order to elucidate the granular structure of the leguminous starches the speed of solubilization of several starches was determined by digestion with dimethyl sulfoxide and with α-amylase. By microscopic investigations with normal and polarized light different forms of erosion were observed in the different starches, all of them less intense than those observed in cereal starches. It was concluded that the starch granules of mucunã seeds are the most homogeneous and have the least porous structure, followed by chick pea, jack, lablab and guanda beans. It is supposed that maturation, climate and soil influence the cristallinity of the granules, resulting in different digestibility.