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31.
TR Bowen F Miller P Castagno J Richards G Lipton 《Canadian Metallurgical Quarterly》1998,18(6):789-793
We analysed 42 differentiated thyroid tumors including 15 follicular adenomas (FA), 13 papillary thyroid cancers (PTC) and 14 follicular thyroid carcinomas (FTC) with 13 microsatellite markers specific for the long arm of human chromosome 7 within 7q31; this region is deleted frequently in several other tumor types. Overall, 20 of the 42 samples analysed (48%) displayed LOH with one or more of the markers tested. LOH was detected most frequently (78%) in FTC, the most malignant of the thyroid tumors. A smallest common deleted region (SCDR) was defined in this tumor type flanked by markers D7S480 and D7S490. This SCDR is distinct from D7S522, the most commonly deleted locus in many other tumors, which was deleted in only one FTC. D7S522 did show LOH in two of six informative PTCs. None of the PTC and only two of the FAs showed LOH in the FTC SCDR. Since FA is considered a premalignant stage of FTC, our results suggest that inactivation of a putative tumor suppressor at 7q31.2 may be acquired during adenoma to carcinoma progression. The absence of LOH at this locus amongst PTC suggests that inactivation of this tumor suppressor is specific for FTC. In conclusion, LOH at 7q31 is a frequent event in differentiated thyroid cancer, and we have defined a 2 cM SCDR specific for FTC. 相似文献
32.
MJ Telford JW Martin BJ Rock LL Turik JE Hairfield 《Canadian Metallurgical Quarterly》1994,19(3):25-9, 33
Small local chapter groups can present quality cost effective regional seminars. Key components are dedication of members, teamwork, and a sense of direction. The following guidelines and information can provide a framework for planning and coordinating a seminar. 相似文献
33.
34.
TH Kim WC Bowen DB Stolz D Runge WM Mars GK Michalopoulos 《Canadian Metallurgical Quarterly》1998,244(1):93-104
The present study has examined the distribution of axons of differing sizes in the optic pathway of the ground squirrel. Axon diameters were measured from electron micrographs at various locations across sections of the optic nerve and tract, and total distributions and numbers were estimated. In both the nerve and tract, roughly 1.2 million optic axons were present. The population of optic axons had a unimodal size distribution, peaking at 0.9 microm in diameter and having an extended tail toward larger diameters. Local axon diameter distributions in the optic tract indicated distinct (though partially overlapping) axon diameter classes, including one of fine sizes peaking at 0.8-0.9 microm, a second of medium sizes peaking around 1.7-1.8 microm, and a third composed of the larger fibers with diameters up to 4.8 microm. The fine-caliber axons were found at all locations in the tract, and were the only axons present immediately adjacent to the pia, while the medium- and coarse-caliber axons were found at deeper locations. Curiously, the larger axons were found primarily in the medial parts of the tract, where axons from the dorsal retina normally course. A similarly restricted distribution of the larger axons was observed in the dorsotemporal parts of the optic nerve, suggesting that this difference in the tract may relate to an asymmetric distribution of ganglion cells on the retina giving rise to these axons. Measurements of axonal size taken within the optic fiber layer in dorsal and ventral parts of the retina confirmed this asymmetry, consistent with previous demonstrations of soma size differences in the dorsal versus ventral retina. The partial segregation of axons by size in the optic tract of the ground squirrel then reflects both the asymmetric distribution of retinal ganglion cell classes and the chronotopic reordering of optic axons that occurs within the chiasmatic region. 相似文献
35.
CE Lewis V George M Fouad V Porter D Bowen N Urban 《Canadian Metallurgical Quarterly》1998,19(5):461-476
The Women's Health Trial:Feasibility Study in Minority Populations (WHT:FSMP) examined the feasibility of recruiting postmenopausal women from a broad range of racial and socioeconomic backgrounds into a primary prevention trial requiring marked reductions in dietary fat. Postmenopausal women aged 50-79 yr who had no history of cardiovascular disease or cancer and who consumed 36% or more total energy from fat qualified to participate. We randomized the women into dietary intervention (60%) or control (40%) groups; we aimed to randomize 750 women in 18 months in each of the three clinical centers. All centers achieved goals for randomization based on ethnicity, and two centers exceeded overall recruitment goals. The greatest source of randomized participants was mass mailing, followed by items in the media, referrals, and community outreach. Recruitment yields were generally similar for the ethnic groups but lower for less-educated participants. The experience of WHT:FSMP indicates that postmenopausal women from the African-American, Hispanic, and non-Hispanic white communities can be recruited into dietary intervention studies for the prevention of disease. 相似文献
36.
以渭河拦河闸为例,基于ADINA有限元分析软件,建立拦河闸三维有限元模型,采用振型分解反应谱法对闸室结构进行地震动响应计算分析,并根据计算结果对拦河闸进行抗震安全评价。计算结果表明:拦河闸闸室结构前5阶振型主要体现为横梁和机架桥结构的振动,符合一般规律;边孔横梁与机架桥联接部位以及机架桥与闸墩联接部位出现了较大拉应力,其最大拉应力数值超过了混凝土动态抗拉强度标准值,但考虑局部配筋量后,拉应力数值满足安全需求;在地震作用最不利工况下,拦河闸整体闸室结构抗滑稳定安全因数为1.68,满足安全需求;拦河闸抗震安全满足标准要求,其抗震等级评定为A级。 相似文献
37.
提出了一种面向大视场高精度视觉测量的多红外目标靶点(红外LED)亮度自适应控制方法。以微控制器PIC16F873A和LED驱动芯片MAX6964作为核心器件,设计了可满足大空间范围内靶点亮度控制需求的多目标靶点控制驱动器。为了使LED在近距测量时的调节精度和远近距离测量时的发光亮度都能满足要求,根据MAX6964输出特点设计了PWM信号输出电路,并采用推挽电路驱动LED。实验证明,目标靶点在CCD相机上成像光斑稳定一致。 相似文献
38.
The empowerment of service workers: what, why, how, and when 总被引:17,自引:0,他引:17
In recent years, businesses have rushed to adopt an empowerment approach to service delivery in which employees face customers "free of rulebooks," encouraged to do whatever is necessary to satisfy them. But that approach may not be right for everyone. Bowen and Lawler look at the benefits and costs of empowering employees, the range of management practices that empower employees to varying degrees, and key business characteristics that affect the choice of approaches. Managers need to make sure that there is a good fit between their organizational needs and their approach to frontline employees. 相似文献
39.
Joseph R. Fox P. Costa Kokoropoulos Gary H. Wiseman H. K. Bowen 《Journal of Materials Science》1987,22(12):4528-4531
Organosilanes of the general formula R
x
Si(OR)4–x
(where R is an alkyl group and R = CH3 or CH2CH3) were used to sterically stabilize hexane dispersions of submicrometre silica spheres. The dispersions were characterized according to sediment volume results. For 0.5m silica particles, the sediment density increased by more than a factor of three up to 50 to 55% of theoretical in the presence of organosilanes with 12 or more carbons in the R group. Solid-state13C nuclear magnetic resonance was used to characterize the powder-dispersant interaction; this technique can distinguish between carbons in the R group of the organosilane and residual organic groups in the silica. Scanning electron micrographs of filter compacts were used to further characterize the dispersions and indicated the presence of primary particles as well as small agglomerates. 相似文献
40.