Comparison of deposition models for a TEOS LPCVD process

We present a comparison of models describing the pyrolytic deposition of SiO₂ with a low pressure chemical vapor deposition process. In order to meet industrial simulation requirements, e.g. accuracy and fast delivery of results, we present an overview of established and new models, their use within TCAD applications, and their best results which have been obtained by calibrations according to SEM measurements.     

Oberflächenwellen‐Strukturen in Cu‐Damaszentechnologie

Application of the Copper Damascene Technology to Surface Acoustic Wave Structures A novel fabrication technology for power SAW devices with embedded interdigital transducers of a copper thin film system (copper damascene technology) is described. Such SAW structures have a significantly higher power durability and lifetime compared to usual Al‐based transducers. These properties denote that they become attractive for new applications where high SAW amplitudes and a flat surface of the device are required for these applications.     

Leveraging federal research and development for united states science and technology

Summary The United States continues to depend heavily on science and technology for ensuring its defense needs, promoting human welfare, and enhancing its economic competitiveness. I hope that my comments have helped to reinforce the point that we, as a nation, must do a better job of leveraging the federal investment in R & D. I have used examples in materials science and engineering to illustrate how this can be done, because materials science and engineering are crucial to our security and competitiveness, as pointed out in the National Research Council’s report. I also took the liberty of telling you about the broad diversity of the materials program at Los Alamos by picking my examples from Los Alamos’ work. In closing, I recognize fully that what I have discussed today is only part of what is required to maintain national security and enhance competitiveness. I believe that, first and foremost, we must get United States industry back into the lead. And the United States government must address the macroeconomic issues and deal with the crisis in education as well. But I also believe that Los Alamos can help in leveraging the federal R & D investment.     

Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment

Our previous studies demonstrated that huperzine A, a reversible and selective acetylcholinesterase inhibitor, exerts beneficial effects on memory deficits in various rodent models of amnesia. To extend the antiamnesic action of huperzine A to nonhuman primates, huperzine A was evaluated for its ability to reverse the deficits in spatial memory produced by scopolamine in young adult monkeys or those that are naturally occurring in aged monkeys using a delayed-response task. Scopolamine, a muscarinic receptor antagonist, dose dependently impaired performance with the highest dose (0.03 mg/kg, i.m.) producing a significant reduction in choice accuracy in young adult monkeys. The delayed performance changed from an average of 26.8/30 trials correct on saline control to an average of 20.2/30 trials correct after scopolamine administration. Huperzine A (0.01-0. 1 mg/kg, i.m.) significantly reversed deficits induced by scopolamine in young adult monkeys on a delayed-response task; performance after an optimal dose (0.1 mg/kg) averaged 25.0/30 correct. In four aged monkeys, huperzine A (0.001-0.01 mg/kg, i.m.) significantly increased choice accuracy from 20.5/30 on saline control to 25.2/30 at the optimal dose (0.001 mg/kg for two monkeys and 0.01 mg/kg for the other two monkeys). The beneficial effects of huperzine A on delayed-response performance were long lasting; monkeys remained improved for about 24 h after a single injection of huperzine A. This study extended the findings that huperzine A improves the mnemonic performance requiring working memory in monkeys, and suggests that huperzine A may be a promising agent for clinical therapy of cognitive impairments in patients with Alzheimer's disease.     

Amifostine protects normal tissues from paclitaxel toxicity while cytotoxicity against tumour cells is maintained

The objectives of this study were to evaluate the protective effects of amifostine against paclitaxel-induced toxicity to normal and malignant human tissues. Haematopoietic progenitor colony assays were used to establish the number of CFU-GEMM and BFU-E colonies after incubation with WR-1065 alone, Amifostine alone, paclitaxel (2.5 or 5 microM) +/- WR-1065 or amifostine. MTT and alkaline elution assays evaluated the in vitro growth inhibitory and DNA damaging effects, respectively, of paclitaxel with or without amifostine against normal human fibroblasts and human non-small cell lung cancer (NSCLC) cells. This combination was also evaluated in vivo using severe combined immune deficient (scid) mouse models of early (non-palpable tumours) and advanced (palpable tumours) human ovarian cancer. Human 2780 ovarian cancer cells were inoculated subcutaneously while paclitaxel and amifostine were administered intraperitoneally. A brief exposure (15 min) to amifostine not only protected human haematopoietic progenitor colonies from paclitaxel toxicity, but stimulated the growth of CFU-GEMM and BFU-E beyond control values. Amifostine protected normal human lung fibroblasts from paclitaxel-induced cytotoxicity and DNA single-strand breaks. However, paclitaxel cytotoxicity and DNA single-strand breaks were actually enhanced by pretreatment with amifostine in the NSCLC model. Importantly, amifostine did not interfere with paclitaxel antitumour activity even with prolonged exposure (24.5 h) of the lung cancer cells to high concentrations (1.2 mM) in vitro or following five repetitive high doses (200 mg/kg) given to scid mice with human ovarian cancer xenografts. Indeed, under certain circumstances, amifostine resulted in sensitisation of tumour cells to paclitaxel. Our results confirm previous reports of the ability of amifostine to protect normal tissues from the toxic effects of chemotherapy drugs and now extend these observations to paclitaxel.     

Multiobjective Groundwater Management Using Evolutionary Algorithms

Sustainable management of groundwater resources is of crucial importance for regions where freshwater supply is naturally limited. Long-term planning of groundwater usage requires computer-based decision support tools: on the one hand, they must be able to predict the complex system dynamics with sufficient accuracy, on the other, they must allow exploring management scenarios with respect to different criteria such as sustainability, cost, etc. In this paper, we present a multiobjective evolutionary algorithm for groundwater management that optimizes the placement and the operation of pumping facilities over time, while considering multiple neighboring regions which are economically independent. The algorithm helps in investigating the cost tradeoffs between the different regions by providing an approximation of the Pareto-optimal set, and its capabilities are demonstrated on a three-region problem. The application of the proposed methodology can also serve as a benchmark problem as shown in this paper. The corresponding implementation is freely available as a precompiled module at http://www.tik.ee.ethz.ch/pisa.     

A generalisation of the interval Newton single-step method for nonlinear systems of equations

In this paper interval iteration methods for solving large nonlinear systems of equations are considered. Already well-known methods are combined to a new one, whose enclosing properties are better than those of previous methods. Convergence of this new method is shown, based on a new convergence proof for the interval Newton single-step method. The central concept in this case is the fixpoint inverse of an interval matrix. Practical tests with nonlinear systems of equations arising from discretisation of certain elliptic partial differential equations show the efficiency of the new method.