A geriatric medical residency program. A four-year experience

Geriatricians are needed to further improve the health care of elderly Americans. The first formalized geriatric residency program in the United States was developed at the Mount Sinai City Hospital Center in New York, and this has produced a second program at the Jewish Institute for Geriatric Care at Long Island Jewish-Hillside Medical Center, New Hyde Park, New York. The goals of this training are to develop special clinical skills to deal with the medical and psychosocial problems of the elderly, and to achieve the ability to develop health care systems for the elderly. Emphasis is on a multileveled system, including home, outpatient, acute hospital, convalescent unit, and long-term institution care. The training period is 12 to 24 months, after an initial 24 to 36 months of standard internal medicine, thus fulfilling the requirements for board eligibility in internal medicine.     

Gastrointestinal metabolism of cadmium in experimental iron deficiency;

The average gastrointestinal uptake 4 h after an intragastric dose of 400 nmol of cadmium chloride labeled with 109CdCl2 in iron-deficient mice, 25%, was significantly greater than the result, 16%, in iron-normal animals, and more cadmium entered the body of the former, 3.8%, than the latter, 2% (P less than 0.05). Between 4 and 72 h, gastrointestinal radioactivity declined without further increase in body activity; however, more radiocadmium remained in the duodenum of iron-deficient than iron-normal animals (P less than 0.05). The radiocadmium sequestered in the duodenum was bound to a protein with a molecular weight of about 12,000. After subcutaneous injection of radiocadmium, the rate of excretion of radioactivity from the body was similar in iron-normal and iron-deficient mice; however, a greater proportion of the injected dose accumulated in the duodenum of the iron-deficient animals (P less than 0.05). Thus, the intestinal adapative response to iron deficiency may enhance cadmium toxicity, whereas sequestration and subsequent excretion of cadmium by the intestinal mucosa serves to protect the body against toxic effects. The duodenum, particularly in iron-deficient mice, is especially vulnerable to the toxic effects of cadmium.     

Cyclophosphamide and low-dose prednisone therapy in patients with systemic sclerosis (scleroderma) with interstitial lung disease

Fourteen patients with systemic sclerosis (SSc, scleroderma) and interstitial lung disease were treated with oral cyclophosphamide (1-2 mg/kg/day) and low dose prednisone (< 10 mg/day). There was a significant improvement in FVC after 6 months compared to entry values (2.21 +/- 0.19 l vs. 2.03 +/- 0.15 l, p < 0.02). Improvement was maintained at 12 months (2.27 +/- 0.27 l, p < 0.05) and 18-24 months (2.60 +/- 0.28 l, p < 0.001). In 12 cases followed for 18-24 months, FVC was stable or improved. No significant improvement or decline was noted for the DLCO. Side effects included cytopenia (2), infection (1), and hemorrhagic cystitis (2), and one possible related malignancy. A controlled prospective trial of cyclophosphamide is warranted in patients with SSc and active interstitial lung disease.     

Coplanar transmission lines on thin substrates for high-speedlow-loss propagation

We investigate the attenuation and phase velocity characteristics of coplanar strip (CPS) transmission lines designed for high-speed, low-loss propagation at sub-THz frequencies. Photoconductor switches driven by femtosecond optical pulses were used to generate propagating picosecond electrical transients. External electrooptic sampling was used to measure the time-domain impulse-response characteristics with subpicosecond time resolution. The finite-difference transmission-line-matrix (FD-TLM) numerical method was used to model picosecond pulse propagation on identical transmission lines. The experiment and the numeric simulations have clarified nonquasistatic high-frequency effects and were shown to agree over a 500 GHz frequency range. Additionally, analytic quasi-static velocity and characteristic impedance formulas have been verified and their frequency range of validity established for the investigated CPS geometries. Radiation into the substrate is the dominant loss mechanism at frequencies above ~100 GHz for the CPS lines on thick substrates. CPS transmission line fabrication on thin substrates has been proposed as a method for reducing high-frequency loss and increasing the microwave propagation velocity. CPS transmission lines fabricated on 8-μm-thick Si membranes have been studied and demonstrated to possess the desired high-speed, low-loss properties