Utility of gamma rays in prophylaxis of transmissible malaria by blood transfusion

The in vitro dissolution of ciprofloxacin from commercially available tablets and capsules in China was studied using the USP apparatus I to compare the product performance from nine different manufacturers. Cumulative release greater than 75% was obtained from all of the products tested within 45 min. However, statistically significant differences were found between some of the products when in vitro data were analyzed using the Weibull function, similarity factor (f2), and multivariate analysis of variances.     

Determination of fluoxetine and norfluoxetine concentrations in cadaveric allograft skin

Fluoxetine hydrochloride is the sixth most prescribed drug in the United States and is administered to treat major depression. A cadaveric skin donation was obtained from a 46-year-old woman who died as a result of a fluoxetine overdose. Due to the potential penetration of the drug and its major metabolite, norfluoxetine, into skin, the safety of using the skin as an allograft was questioned. Our evaluation showed that mean concentrations in skin were 2304+/-175 and 1353+/-102 ng/g of skin, respectively. The skin:plasma ratio was 0.41. Clinically, the amount of fluoxetine that can be transferred to an allograft recipient depends on many factors. Based on penetration of drug and metabolite into skin, one would have to evaluate carefully the risk:benefit ratio of using allografts from a donor who died from a fluoxetine overdose.     

Psychological differentiation, event uncertainty, and heart rate

Psychological differentiation and uncertainty about receiving a painful noise were examined for their effects on heart rate during the anticipatory, impact and recovery phases of the tone presentation. Psychologically differentiated and nondifferentiated subjects were randomly assigned to three event uncertainty conditions (5 percent, 50 percent, 95 percent probability of noise). Subjects were informed of the probability of receiving the noise, as well as the time of occurrence as indicated by a sequentially numbered visual display. Subjects received the noise on the second of the experiment's two trials. Cognitive style and event uncertainty interacted during the anticipatory phase--i.e., differentiated subjects showed a monotonic increase in heart rate with increasing probability of receiving the noise that represents preparation for instrumental activity. Results are consistent with the theory that meaningful personality-stress relationships may be obtained when examining stimulus-oriented dispositions.     

Reduction of the behavioral effects of delta9-tetrahydrocannabinol by hyperbaric pressure

The temporal order of development of olfactory, hippocampal and thalamocortical connections has been determined by light microscopy. Scalpel lesions were made to interrupt these connections and the resulting terminal degeneration was stained by Eager's method (1970). A post-operative survival time of one to four days was used. Evidence of the development of these connections was first obtained at the following ages: Olfactory mucosa to olfactory bulb: axon fascicles by 16 days of gestation and terminals in glomeruli at birth; Olfactory bulb to prepyriform cortex at birth; Prepyriform to entorhinal cortex at 13 days after birth; Entorhinal cortex to hippocampus (the perforant path) at 9 days; Hippocampal dentate-Ammonic mossy fibres at 9 days; Hippocampal efferent projection to the septum at birth; Subicular projections to the anterior thalamus at birth and to the mammillary body at 6 days; Hippocampal commissural connections at birth; Corticothalamic and thalamocortical connections by 2 days. These results are discussed in relation to the question of how the development of brain connections is programmed.