Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity

Organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. The products are high molecular weight polymers. Infrared spectroscopy of the products shows new bands characteristic of the formation of Sn–N and Sn–O bonds consistent with the proposed structure. MALDI-TOF MS below 2000 Da shows the presence of organotin and acyclovir units containing these two moieties. The products show moderate inhibition of a number of cancer cell lines and exhibit the ability to inhibit a number of viruses, particularly the herpes simplex virus-1 and varicella zoster virus that are responsible for herpes, chicken pox and shingles.     

The Effects of Power Law Fluid Rheology on Coil Heat Transfer for Agitated Vessel in the Transitional Flow Regime

A CFD model of heat transfer from power‐law fluids to helical cooling coils in the transitional flow regime of a baffled tank mixed with a pitched blade turbine was developed with Fluent^TM. The model captured local temperature and velocity gradients. Simulations were run, varying Re, Pr, K and n. The results indicate that a Sieder‐Tate type correlation, with the exponent on and the coefficient in front of the Reynolds number being a function of n, is recommended for estimating ho. Also, a new two coil bank design was found to be more efficient when 450 < Re < 650.     

Talking with some directors of the U.S. national laboratories

JOM surveyed the leaders of the U.S. Department of Energy’s (DOE) national laboratories for perspectives on some of the U.S. science and engineering community’s most pressing issues regarding R&D, globalization, national security, and budget constraints. The journal posed the same five questions to each lab director. What follows are responses from six of the directors: Michael R. Anastasio, Lawrence Livermore National Laboratory; Dan Arvizu, National Renewable Energy Laboratory (NREL); John J. Grossenbacher, Idaho National Laboratory (INL); Thomas O. Hunter, Sandia National Laboratories; Robert Rosner, Argonne National Laboratory; and Jeffrey Wadsworth, Oak Ridge National Laboratory (ORNL). Kelly Roncone is news editor for JOM.     

Driving a Wedge Between Evidence and Beliefs: How Online Ideological News Exposure Promotes Political Misperceptions

This article has 2 goals: to provide additional evidence that exposure to ideological online news media contributes to political misperceptions, and to test 3 forms this media‐effect might take. Analyses are based on representative survey data collected during the 2012 U.S. presidential election (N = 1,004). Panel data offer persuasive evidence that biased news site use promotes inaccurate beliefs, while cross‐sectional data provide insight into the nature of these effects. There is no evidence that exposure to ideological media reduces awareness of politically unfavorable evidence, though in some circumstances biased media do promote misunderstandings of it. The strongest and most consistent influence of ideological media exposure is to encourage inaccurate beliefs regardless of what consumers know of the evidence.     

A Review of Element-Based Galerkin Methods for Numerical Weather Prediction: Finite Elements,Spectral Elements,and Discontinuous Galerkin

Numerical weather prediction (NWP) is in a period of transition. As resolutions increase, global models are moving towards fully nonhydrostatic dynamical cores, with the local and global models using the same governing equations; therefore we have reached a point where it will be necessary to use a single model for both applications. The new dynamical cores at the heart of these unified models are designed to scale efficiently on clusters with hundreds of thousands or even millions of CPU cores and GPUs. Operational and research NWP codes currently use a wide range of numerical methods: finite differences, spectral transform, finite volumes and, increasingly, finite/spectral elements and discontinuous Galerkin, which constitute element-based Galerkin (EBG) methods. Due to their important role in this transition, will EBGs be the dominant power behind NWP in the next 10 years, or will they just be one of many methods to choose from? One decade after the review of numerical methods for atmospheric modeling by Steppeler et al. (Meteorol Atmos Phys 82:287–301, 2003), this review discusses EBG methods as a viable numerical approach for the next-generation NWP models. One well-known weakness of EBG methods is the generation of unphysical oscillations in advection-dominated flows; special attention is hence devoted to dissipation-based stabilization methods. Since EBGs are geometrically flexible and allow both conforming and non-conforming meshes, as well as grid adaptivity, this review is concluded with a short overview of how mesh generation and dynamic mesh refinement are becoming as important for atmospheric modeling as they have been for engineering applications for many years.     

Comparing Public Perceptions of Alternative Water Sources for Potable Use: The Case of Rainwater,Stormwater, Desalinated Water,and Recycled Water

This research investigated how people’s perceptions of alternative water sources compare with their perceptions of other technologies, and identified significant predictors of comfort with different alternative water sources. We drew on data from four questionnaire survey studies with a total sample of more than 1200 Australian participants. Relative levels of comfort with the alternative water sources was consistent across the four studies: comfort was always highest for drinking rainwater and lowest for drinking recycled water, with comfort with drinking treated stormwater and desalinated water sitting between these two. Although comfort with drinking recycled water was always lowest of the four alternative water sources, participants were significantly more comfortable with drinking recycled water than they were with nuclear energy, or with using genetically modified plants and animals for food. In general, demographic variables were less important predictors of comfort with alternative water sources than were psychological variables; only age and gender emerged as relatively consistent predictors for recycled water, stormwater, and desalinated water, with older participants and males more comfortable with drinking these water sources. Of the psychological variables, participants’ comfort with technology in general, trust in science and trust in government emerged consistently as significant positive predictors of comfort with drinking recycled water, stormwater, and desalinated water.

     

How In-Home Technologies Mediate Caregiving Relationships in Later Life

In-home technologies can support older adults' activities of daily living, provide physical safety and security, and connect elders to family and friends. They facilitate aging in place while reducing caregiver burden. One of older adults' primary concerns about in-home technologies is their potential to reduce human contact, particularly from cherished caregivers. In this exploratory in situ study, we provided an ecosystem of networked monitoring technologies to six older adults and their caregivers. We analyzed the amount and content of communication between them. The amount of noncomputer-mediated communication did not decrease through the 6-week study. The content of communication coalesced into four themes: communication about the technologies, communication facilitated by technologies, intrusiveness of technologies, and fun and playfulness with the technologies. Results suggest that in-home technologies, designed with sensitivity to older adults' primary motivations, have the potential to shape and tailor important relationships in later life.     

It's the Thought that Counts: The Mediating Effects of Information Processing in Virtual Team Decision Making

Abstract

Previous research shows that although collaboration technology can improve the exchange of information during team decision making, one of the challenges is that this better discussion often does not lead to better decisions. In this paper, we investigate the impact of individual information processing on team decision making. We investigated the effects of two types of collaboration technology when participants were either the member of a team majority or a team minority. There was little impact due to the majority/minority, but the use of collaboration technology that required users to categorize the comments they received from others resulted in increased information processing, which in turn led to better decisions and more satisfied participants.     

RSS – MORE THAN JUST NEWS FEEDS

RSS (Really Simple Syndication/RDF Site Summary) is a simple lightweight format that was originally used for news alerts and content syndication. It is now being used in a wide range of applications. This paper describes the background to RSS and describes the various ways in which RSS can be used. Examples are provided of the ways in which RSS can be viewed and the variety of approaches for creating RSS. The paper argues that, although there is still confusion over the different types of RSS standards, the format is an essential for use in digital library services.     

Thiamine concentrations in lake whitefish eggs from the upper Great Lakes are related to maternal diet

Thiamine deficiency is responsible for reproductive impairment in several species of salmonines in the Great lakes, and is thought to be caused by the consumption of prey containing thiaminase, a thiamine-degrading enzyme. Because thiaminase levels are extremely high in dreissenid mussels, fish that prey on them may be susceptible to thiamine deficiency. We determined thiamine concentrations in lake whitefish Coregonus clupeaformis eggs from the upper Laurentian Great Lakes to assess the potential for thiamine deficiency and to determine if thiamine concentrations in lake whitefish eggs were related to maternal diet. Mean thiamine concentrations in lake whitefish eggs were highest in Lake Huron, intermediate in Lake Superior, and lowest in Lake Michigan. Some fish had thiamine concentrations below putative thresholds for lethal and sublethal effects in salmonines, suggesting that some larval lake whitefish may currently be at risk of at least sublethal effects of low thiamine concentrations, although thiamine thresholds are unknown for lake whitefish. Egg thiamine concentrations in lake whitefish eggs were statistically significantly related to isotopic carbon signatures, suggesting that egg thiamine levels were related to maternal diet, but low egg thiamine concentrations did not appear to be associated with a diet of dreissenids. Egg thiamine concentrations were not statistically significantly related to multifunction oxidase induction, suggesting that lower egg thiamine concentrations in lake whitefish were not related to contaminant exposure.