Oxidation behaviour of a Mo(Si,Al)2 based composite at 1500 °C

The oxidation of a Mo(Si,Al)₂ composite is investigated at 1500 °C in dry air using exposure times from 1 to 1000 h. Cross sections are examined with Scanning Electron Microscopy (SEM) and the phase composition is analyzed by X-ray diffraction (XRD). The material forms a continuous and protective alumina layer, the growth of the alumina layer following parabolic kinetics. Immediately below the scale Mo(Si,Al)₂ is replaced by a Mo₅(Si,Al)₃ layer due to the flux of aluminum to the scale. The Al concentration in the Mo(Si,Al)₂ phase in the underlying substrate decreases from 27% before exposure to 16–17% after 1000 h. The continuous alumina layer becomes covered by a top layer consisting of alumina grains embedded in a viscous melt with approximate composition 7 Na₂O–15 Al₂O₃–78 SiO₂. With time, sodium is volatilized from the melt and the top scale layer transforms to a mixture of alumina, mullite and silica melt.     

Key technologies for IMT-advanced mobile communication systems

WINNER is an ambitious research project aiming at identification, development, and assessment of key technologies for IMTAdvanced mobile communication systems. WINNER has devised an OFDMA-based system concept with excellent system-level performance for flexible deployments in a wide variety of operating conditions. The WINNER system provides a significant step forward from current 3G systems. Key innovations integrated into the system concept include flexible spectrum usage and relaying, adaptive advanced antenna schemes and pilot design, close to optimal link adaptation, hierarchical control signaling, and a highly flexible multiple access scheme. The end-to-end performance assessment results demonstrate that the WINNER concept meets the IMTAdvanced requirements.     

Wideband Low‐Reflection Transmission Lines for Bare Chip on Multilayer PCB

The pad pitch of modern radio frequency integrated circuits is in the order of few tens of micrometers. Connecting a large number of high‐speed I/Os to the outside world with good signal fidelity at low cost is an extremely challenging task. To cope with this requirement, we need reflection‐free transmission lines from an on‐chip pad to on‐board SMA connectors. Such a transmission line is very hard to design due to the difference in on‐chip and on‐board feature size and the requirement for extremely large bandwidth. In this paper, we propose the use of narrow tracks close to chip and wide tracks away from the chip. This narrow‐to‐wide transition in width results in impedance discontinuity. A step change in substrate thickness is utilized to cancel the effect of the width discontinuity, thus achieving a reflection‐free microstrip. To verify the concept, several microstrips were designed on multilayer FR4 PCB without any additional manufacturing steps. The TDR measurements reveal that the impedance variation is less than 3 Ω for a 50 Ω microstrip and S11 better than –9 dB for the frequency range 1 GHz to 6 GHz when the width changes from 165 µm to 940 µm, and substrate thickness changes from 100 µm to 500 µm.     

Injection à très haute pression

Un jet à très haute pression d'eau et d'air en même temps qu'une injection de pâte de ciment est en train de ?révolutionner? la pratique des injections dans le sol et consolidation des fondations. Cette technique développée en Suède est brièvement exposée ici. L'article s'appuie sur une note résumée publiée par le Conseil suédois pour la recherche sur la construction.     

Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus

Leptin, the protein product of the adipose tissue-specific ob (obese) gene (1), reduces the body weight, adiposity and food intake of obese ob/ob mice on peripheral or central injection (2, 3, 4). [125I]leptin binding has been detected in mouse choroid plexus (5), from which a leptin receptor gene was expression cloned (5). The gene has at least 6 splice variants (6, 7). Leptin receptor mRNA was localized in the hypothalamus by in situ hybridization being particularly abundantly expressed in the arcuate nucleus (8). There is evidence linking the physiological effects of injected leptin with hypothalamic neuropeptide Y (9, 10) (NPY), which has potent central effects on food intake and energy balance (11), and is also expressed in the arcuate nucleus. Here we report dual in situ hybridization studies for leptin receptor and NPY gene expression in the mouse arcuate nucleus, where the majority of cells examined expressed both genes. This provides the first direct evidence that leptin acts on cells that express NPY mRNA.     

High-dose thiotepa and etoposide-based regimens with autologous hematopoietic support for high-risk or recurrent CNS tumors in children and adults

The prognosis in patients with primary brain tumors treated with surgery, radiotherapy and conventional chemotherapy remains poor. To improve outcome, combination high-dose chemotherapy (HDC) has been explored in children, but rarely in adults. This study was performed to determine the tolerability of three-drug combination high-dose thiotepa (T) and etoposide (E)-based regimens in pediatric and adult patients with high-risk or recurrent primary brain tumors. Thirty-one patients (13 children and 18 adults) with brain tumors were treated with high-dose chemotherapy: 19 with BCNU (B) and TE (BTE regimen), and 12 with carboplatin (C) and TE (CTE regimen). Patients received growth factors and hematopoietic support with marrow (n = 15), peripheral blood progenitor cells (PBPC) (n = 11) or both (n = 5). The 100 day toxic mortality rate was 3% (1/31). Grade III/IV toxicities included mucositis (58%), hepatitis (39%) and diarrhea (42%). Five patients had seizures and two had transient encephalopathy (23%). All patients had neutropenic fever and all pediatric patients required hyperalimentation. Median time to engraftment with absolute neutrophil count (ANC) >0.5 x 10(9)/l was 11 days (range 8-37 days). Time to ANC engraftment was significantly longer (P = 0.0001) in patients receiving marrow (median 14 days, range 10-37) than for PBPC (median 9.5 days, range 8-10). Platelet engraftment >50 x 10(9)/l was 24 days (range 14-53 days) in children. In adults, platelet engraftment >20 x 10(9)/l was 12 days (range 9-65 days). In 11 patients supported with PBPC, there was a significant inverse correlation between CD34+ dose and days to ANC (rho = -0.87, P = 0.009) and platelet engraftment (rho = -0.85, P = 0.005), with CD34+ dose predicting time to engraftment following HDC. Overall, 30% of evaluable patients (7/24) had a complete response (CR) (n = 3) or partial response (PR) (n = 4). Median time to tumor progression (TTP) was 7 months, with an overall median survival of 12 months. These TE-based BCNU or carboplatin three-drug combination HDC regimens are safe and tolerable with promising response rates in both children and older adults.     

Anticonvulsant and antibiotic prophylaxis in head injury

The evidence for and against the prophylactic use of anticonvulsants and antibiotics in head injury is reviewed. There is a lack of blinded placebo-controlled trials in this area. On balance there is no compelling evidence to support the use of either anticonvulsant or antibiotic prophylaxis in head injury, with the possible exception of antibiotic prophylaxis in compound depressed skull fractures and penetrating brain injuries.