全文获取类型
收费全文 | 860篇 |
免费 | 5篇 |
专业分类
电工技术 | 5篇 |
综合类 | 1篇 |
化学工业 | 14篇 |
金属工艺 | 1篇 |
机械仪表 | 3篇 |
建筑科学 | 4篇 |
能源动力 | 14篇 |
轻工业 | 4篇 |
水利工程 | 1篇 |
无线电 | 14篇 |
一般工业技术 | 18篇 |
冶金工业 | 779篇 |
自动化技术 | 7篇 |
出版年
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 4篇 |
2015年 | 3篇 |
2014年 | 5篇 |
2013年 | 4篇 |
2012年 | 7篇 |
2011年 | 6篇 |
2010年 | 2篇 |
2009年 | 1篇 |
2008年 | 4篇 |
2007年 | 2篇 |
2005年 | 4篇 |
2004年 | 1篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2001年 | 7篇 |
1999年 | 15篇 |
1998年 | 215篇 |
1997年 | 112篇 |
1996年 | 94篇 |
1995年 | 30篇 |
1994年 | 44篇 |
1993年 | 49篇 |
1992年 | 8篇 |
1991年 | 19篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 12篇 |
1987年 | 10篇 |
1986年 | 20篇 |
1985年 | 9篇 |
1984年 | 1篇 |
1983年 | 5篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 9篇 |
1979年 | 2篇 |
1978年 | 6篇 |
1977年 | 30篇 |
1976年 | 55篇 |
1975年 | 4篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
1968年 | 3篇 |
1966年 | 3篇 |
1965年 | 1篇 |
1955年 | 2篇 |
排序方式: 共有865条查询结果,搜索用时 15 毫秒
51.
Spectrin of the erythrocyte membrane skeleton is composed of alpha- and beta-spectrin, which associate to form heterodimers and tetramers. It has been suggested that a fractional domain (helix C) in the amino-terminal region of alpha-spectrin (Nalpha region) bundles with another fractional domain in the carboxyl-terminal region of beta-spectrin (Cbeta region) to yield a triple alpha-helical bundle and that this helical bundling is largely responsible for tetramer formation. However, there are certain objections to assigning a preeminent role to this helical bundling in the tetramerization reactions. We prepared several recombinant peptides of alpha-spectrin fragments spanning only the Nalpha region (lacking the dimer nucleation site) and quantitatively studied their interaction with beta-spectrin. We found that a majority of the interactions were localized, as expected, in the Nalpha-helix C region but that there was also some contribution from the nonhomologous region. More importantly, the temperature and ionic strength dependence of this interaction in our model peptides was different from that in intact spectrin. We suggest that, although the regions involving the putative helical bundling in alpha- and beta-spectrin undoubtedly play a significant role in tetramerization, regions distal to the Nalpha-helix C region in spectrin are also involved in tetramer formation. Structural flexibility and lateral interactions may play a role in spectrin tetramerization. 相似文献
52.
Yang K. Marshall T. Forman M. Hubert J. Mirth L. Popovic Z. Katehi L.P.B. Whitaker J.F. 《Microwave Theory and Techniques》2001,49(5):849-857
Several Ka-band spatial-amplifier power combiners and their free-space feeds were characterized using a high-resolution extreme-near-field electrooptic measurement technique. The two-dimensional electric-field amplitude and phase maps obtained from several arrays are presented. The usefulness of the technique for diagnostic purposes during the design and prototyping stages of the active arrays is discussed. In particular, the electrooptic maps were shown to be valuable for making improvements in the bias line design in one case, and for isolating faulty unit cells in another case 相似文献
53.
The authors observed 106 children's imitation and responses to maternal control at 14 and 22 months. Imitation was observed in a teaching task in which mothers modeled 3 standard pretend-play sequences. Responses to control were observed in typical discipline contexts. Girls imitated more than boys. Responsive imitation measures were coherent and longitudinally stable and correlated significantly with responsiveness to maternal control. The authors propose that a young child's willingness to imitate his or her parent in a teaching context and to comply in a control context both reflect a responsive or receptive stance toward parental socialization. The consistency of children's responsiveness across contexts has implications for both sociomoral and cognitive development. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
54.
55.
56.
57.
Ribonuclease A variants with potent cytotoxic activity 总被引:1,自引:0,他引:1
Select members of the bovine pancreatic ribonuclease A (RNase A) superfamily are potent cytotoxins. These cytotoxic ribonucleases enter the cytosol, where they degrade cellular RNA and cause cell death. Ribonuclease inhibitor (RI), a cytosolic protein, binds to members of the RNase A superfamily with inhibition constants that span 10 orders of magnitude. Here, we show that the affinity of a ribonuclease for RI plays an integral role in defining the potency of a cytotoxic ribonuclease. RNase A is not cytotoxic and binds RI with high affinity. Onconase, a cytotoxic RNase A homolog, binds RI with low affinity. To disrupt the RI-RNase A interaction, three RNase A residues (Asp-38, Gly-88, and Ala-109) that form multiple contacts with RI were replaced with arginine. Replacing Asp-38 and Ala-109 with an arginine residue has no effect on the RI-RNase interaction. In addition, these variants are not cytotoxic. In contrast, replacing Gly-88 with an arginine residue yields a ribonuclease (G88R RNase A) that retains catalytic activity in the presence of RI and is cytotoxic to a transformed cell line. Replacing Gly-88 with aspartate also yields a ribonuclease (G88D RNase A) with a decreased affinity for RI and cytotoxic activity. The cytotoxic potency of onconase, G88R RNase A, and G88D RNase A correlate with RI evasion. We conclude that ribonucleases that retain catalytic activity in the presence of RI are cytotoxins. This finding portends the development of a class of chemotherapeutic agents based on pancreatic ribonucleases. 相似文献
58.
Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat 总被引:2,自引:0,他引:2
KL Houseknecht JP Vanden Heuvel SY Moya-Camarena CP Portocarrero LW Peck KP Nickel MA Belury 《Canadian Metallurgical Quarterly》1998,244(3):678-682
Conjugated linoleic acid (CLA) is a naturally occurring fatty acid which has anti-carcinogenic and anti-atherogenic properties. CLA activates PPAR alpha in liver, and shares functional similarities to ligands of PPAR gamma, the thiazolidinediones, which are potent insulin sensitizers. We provide the first evidence that CLA is able to normalize impaired glucose tolerance and improve hyperinsulinemia in the pre-diabetic ZDF rat. Additionally, dietary CLA increased steady state levels of aP2 mRNA in adipose tissue of fatty ZDF rats compared to controls, consistent with activation of PPAR gamma. The insulin sensitizing effects of CLA are due, at least in part, to activation of PPAR gamma since increasing levels of CLA induced a dose-dependent transactivation of PPAR gamma in CV-1 cells cotransfected with PPAR gamma and PPRE X 3-luciferase reporter construct. CLA effects on glucose tolerance and glucose homeostasis indicate that dietary CLA may prove to be an important therapy for the prevention and treatment of NIDDM. 相似文献
59.
Plain film imaging remains important for the diagnosis and surveillance of scoliosis, as well as for the detection of complications after surgery. New means of treating scoliosis have become established and should be understood by the radiologist. To the well-known postoperative complications, including pneumothorax, pneumonia, and gastrointestinal obstruction, are added new specific potential problems with the new surgical methodology. 相似文献
60.