The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening

We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM) against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.     

铝溶胶的制备条件对其凝胶成球性能的影响

以硝酸和拟薄水铝石为原料制备了铝溶胶,考察了x(H+/Al摩尔比)和φ(六亚甲基四胺溶液与硝酸溶液的体积比)值对铝溶胶在油中凝胶成球性能的影响。使用氧化铝颗粒的Zingg指数对铝溶胶制备条件进行了评价。结果表明:铝溶胶和半透明铝溶胶的制备条件是x分别大于0.05和0.07;增大x和φ值均利于铝溶胶的凝胶化,但过大的x和φ值不利于溶胶收缩成球;Zingg曲线在1附近的平稳区间对应的x和φ值是合适的铝溶胶制备条件。     

主动桁架模态的试验研究

以一个78杆空间桁架为试验模型，研究线性主动结构构型的试验问题。对构型主动结构及特性分析的试验技术做了实践。采用耦合模态空间的二次型最优控制算法，利用压电堆作动器，构型了主动桁架。采用dAPACE半实物物理仿真操作平台，分别测试了被动桁架和主动桁架的模态振型和模态参数，并测试了主动桁架在随机激励作用下的传递函数。结果表明，主动结构由于引入了控制系统而使得结构的阻尼增大，同时由于在压电作动器附近的杆单元的模态受到抑制，所以主动桁架的模态与相应的被动桁架的模态存在着较大的差别。     

ZOW2009意大利展前报道—意大利家具配件制造商全力支持维罗纳

ZOW传统意义上是为家具供应商提供—个高效的市场平台。ZOW维罗纳展是在意大利举办的具有国际水平的行业盛会。近来通过扩充,实现了一个重要的目标：2009年参展商名单等同于家具配件行业中最重要的一些品牌厂商名单。今年的ZOW意义利展,德国的Interzum和Ligna的出席,为将要到来的10月21-24日在意大利维罗纳举办的ZOW给予了一些证实。     

某水源热泵空调工程取水系统设计

为解决重庆市某水源热泵空调工程的取水难题,对该取水工程的取水量、取水方案、取水泵、输水管线等进行了计算和设计.该工程充分利用项目所在地区域规划布局,采用在景观凉亭正下方河底修建取水平台和金属格栅、用潜水泵直接从河中取水的取水技术,省去了取水头部和岸边集水竖井,解决了项目区域河段取水点设置难的问题.该工程工艺设计简单、新颖,施工、安装方便,维修管理容易,和周围环境相得益彰.     

Urchin‐Like CoSe2 as a High‐Performance Anode Material for Sodium‐Ion Batteries

Urchin‐like CoSe₂ assembled by nanorods has been synthesized via simple solvothermal route and has been first applied as an anode material for sodium‐ion batteries (SIBs) with ether‐based electrolytes. The CoSe₂ delivers excellent sodiation and desodiation properties when using 1 m NaCF₃SO₃ in diethyleneglycol dimethylether as an electrolyte and cycling between 0.5 and 3.0 V. A high discharge capacity of 0.410 Ah g^?1 is obtained at 1 A g^?1 after 1800 cycles, corresponding to a capacity retention of 98.6% calculated from the 30th cycle. Even at an ultrahigh rate of 50 A g^?1, the capacity still maintains 0.097 Ah g^?1. The reaction mechanism of the as‐prepared CoSe₂ is also investigated. The results demonstrate that at discharged 1.56 V, insertion reaction occurs, while two conversion reactions take place at the second and third plateaus around 0.98 and 0.65 V. During the charge process, Co first reacts with Na₂Se to form Na_xCoSe₂ and then turns back to CoSe₂. In addition to Na/CoSe₂ half cells, Na₃V₂(PO₄)₃/CoSe₂ full cell with excessive amount of Na₃V₂(PO₄)₃ has been studied. The full cell exhibits a reversible capacity of 0.380 Ah g^?1. This work definitely enriches the possibilities for anode materials for SIBs with high performance.     

Ruthenium Nanoparticles on Cobalt‐Doped 1T′ Phase MoS2 Nanosheets for Overall Water Splitting

2D MoS₂ nanostructures have recently attracted considerable attention because of their outstanding electrocatalytic properties. The synthesis of unique Co–Ru–MoS₂ hybrid nanosheets with excellent catalytic activity toward overall water splitting in alkaline solution is reported. 1T′ phase MoS₂ nanosheets are doped homogeneously with Co atoms and decorated with Ru nanoparticles. The catalytic performance of hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is characterized by low overpotentials of 52 and 308 mV at 10 mA cm^?2 and Tafel slopes of 55 and 50 mV decade^?1 in 1.0 m KOH, respectively. Analysis of X‐ray photoelectron and absorption spectra of the catalysts show that the MoS₂ well retained its metallic 1T′ phase, which guarantees good electrical conductivity during the reaction. The Gibbs free energy calculation for the reaction pathway in alkaline electrolyte confirms that the Ru nanoparticles on the Co‐doped MoS₂ greatly enhance the HER activity. Water adsorption and dissociation take place favorably on the Ru, and the doped Co further catalyzes HER by making the reaction intermediates more favorable. The high OER performance is attributed to the catalytically active RuO₂ nanoparticles that are produced via oxidation of Ru nanoparticles.