Preparation and characterization of chemically derived (Pb,La)TiO (3) thin films

Ferroelectric lead lanthanum titanate (PLT) thin films with composition varying from pure PbTiO(3) to PLT 25/100 (0 to 25 mol.% La) were prepared by spin-casting 0.25M solutions containing metallo-organic precursors of Pb, La, and Ti. The dielectric and ferroelectric properties of the thin (410-nm) films were characterized. The dielectric constants of the films varied from ~80 to ~690 for La contents varying from 0 to 25 mol%, respectively. Dissipation factors varied from ~0.03 to ~0.09 over the same compositional range. The temperature dependence of the dielectric properties was also studied to determine the effects of La content on the Curie point (T(c)). As expected, T(c ) was found to decrease with increasing La concentration. Coercive field and remanent polarization also decreased with increased La concentration.     

The first business computer: a case study in user-driven innovation

In 1949, the world's first business computer application was rolled out. The host for the application was a British catering and food-manufacturing company, which had developed and built its own computer, designed for business data processing. The author traces the endeavour's history and presents an analysis of how and why the company-J. Lyons & Co.-was in a natural position to take on the challenge, the precursor of the information revolution we see today     

You Are What You Buy: Mass-Mediated Judgments of People's Worth

Based on only a list of supermarket purchases—cbic "upscale" products or generic brands—people make different judgments about other men's and women's character and responsibility, with heavier media consumers judging buyers of brand-name products as also possessing more personal uirtues.     

The Unfolded Protein Response Sensor PERK Mediates Stiffness-Dependent Adaptation in Glioblastoma Cells

Glioblastoma multiforme (GBM) is the most aggressive brain tumor in adults. In addition to genetic causes, the tumor microenvironment (TME), including stiffening of the extracellular matrix (ECM), is a main driver of GBM progression. Mechano-transduction and the unfolded protein response (UPR) are essential for tumor-cell adaptation to harsh TME conditions. Here, we studied the effect of a variable stiff ECM on the morphology and malignant properties of GBM stem cells (GSCs) and, moreover, examined the possible involvement of the UPR sensor PERK herein. For this, stiffness-tunable human blood plasma (HBP)/alginate hydrogels were generated to mimic ECM stiffening. GSCs showed stiffness-dependent adaptation characterized by elongated morphology, increased proliferation, and motility which was accompanied by F-Actin cytoskeletal remodeling. Interestingly, in PERK-deficient GSCs, stiffness adaptation was severely impaired, which was evidenced by low F-Actin levels, the absence of F-Actin remodeling, and decreased cell proliferation and migration. This impairment could be linked with Filamin-A (FLN-A) expression, a known interactor of PERK, which was strongly reduced in PERK-deficient GSCs. In conclusion, we identified a novel PERK/FLNA/F-Actin mechano-adaptive mechanism and found a new function for PERK in the cellular adaptation to ECM stiffening.     

Longitudinal Electrooptic Effects and Photosensitivities of Lead Zirconate Titanate Thin Films

The feasibility of storing and reading high-density optical information in lead zirconate titanate (PZT) and in lead lanthanum zirconate titanate (PLZT) thin films depends on both the longitudinal electrooptic coefficients and the photosensitivities of the films. This paper describes the methods used to measure the longitudinal electrooptic effects and the photosensitivities of the films. The results of these measurements were used to evaluate a longitudinal quadratic electrooptic R coefficient, a longitudinal linear electrooptic r_c coefficient, and the wavelength dependence of the photosensitivity of a composition of PZT polycrystalline thin film. The longitudinal electrooptic R and r_c coefficients are about an order of magnitude less than the transverse R and r_c coefficients of bulk ceramics of similar compositions. This is attributed to clamping of the film by the rigid substrate. The large birefringence of the films after poling (>10⁻²) suggests that the optic axes of the films are preferentially oriented normal to the film surface. The techniques used in this paper for evaluating the photosensitivities of thin films are based on measuring the photocurrent generated rather than the reduction in coercive voltage (as in bulk ceramics) when the film is exposed to light. The thin film photosensitivities appear to be significantly higher than those of bulk ceramics of similar compositions. The high photosensitivities coupled with the substantial longitudinal electrooptic coefficients combine to establish the feasibility of using PZT or PLZT thin films for optical information storage applications.     

Phase investigations of the Pu-Pt,Pu-Rh,and Pu-Pt-Rh systems

Phase and crystal structure studies performed on the Pu-Pt, Pu-Rh, and Pu-Pt-Rh systems are described. The techniques employed included metallography, X-ray diffraction, and an electron microprobe. Results of these studies are correlated with previous work to obtain phase diagrams for these three systems. Previously unreported PuPt₃-K and $\text{PuPt}{}_3\text{-}\text{k}\text{?}$ polymorphs and a new PuPt₄ phase were identified. Eutectic points in the Pu-Pt and Pu-Rh systems were determined at 89.9 at% Pt and 84.5 at% Rh, respectively. No low melting eutectic alloys or ternary compounds were observed in the Pu- Pt-Rh system. Crystal structures determined by X-ray diffraction measurements were as follows: PuPt₅ (hexagonal, P 6/mmm, CaCu₅-type); PuPt₄ (orthorhombic, Cmmm); and $\text{PuPt}{}_3\text{-}\text{K}\text{?}$ (BC tetragonal, DO_e, PNi₃-type).     

Analysis of flow distribution from high-speed flow actuator using particle image velocimetry and digital speckle tomography

A variety of active flow control (AFC) methods are typically used in low-speed applications; however, the AFC techniques that are available for high-speed, supersonic applications are very limited. Under AFOSR (Air Force Research Laboratory) sponsorship, The Johns Hopkins University Applied Physics Laboratory (JHU/APL) is investigating a device that is intended for high-speed flow control; it is called the SparkJet actuator, which manipulates high-speed flows without active mechanical components. To date, actuator characterization has included computational and experimental techniques including parametric studies and flow visualization techniques to investigate the operation of the SparkJet device under various conditions. This paper focuses on the experimental flow measurement techniques that have been implemented. The results will be used for validating prospective computational studies that investigate the detailed characteristics of the SparkJet’s discharge and cooling stages after an energy deposition pulse. Current efforts include the use of high- resolution particle image velocimetry (PIV) to quantify the quiescent air operation of a single SparkJet pulse. However, the proper seeding of the SparkJet cavity continues to be challenging and has led to the use of digital speckle tomography (DST) to measure the temperature distribution in the core of the SparkJet plume. In this study, improved PIV techniques were used to acquire a higher-resolution image of the SparkJet-entrained flow. These PIV results show that the peak velocity in the entrained flow is around 53 m/s and the plume is sustained for 75–100 μs. Additionally, the DST data show a peak temperature of 1616.3 K at 75 μs and provide supporting information for interpreting the PIV data. These results are intended to calibrate and build confidence in a computational model.     

Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage

Loss of the intracellular antioxidant glutathione (GSH) from the substantia nigra is considered to be an early event in the pathogenesis of Parkinson's disease (PD). While the cause of the loss is unclear, an imbalance in the enzymes associated with the synthesis, utilisation, degradation and translocation of GSH has been implicated. The enzyme glutathione reductase is also important in GSH homeostasis: it regenerates GSH from the oxidised from (GSSG). However, to date the activity and regulation of glutathione reductase in conditions such as PD have not been explored. In view of this we have measured the effects of GSH depletion on glutathione reductase activity of the rat brain. Other glutathione related enzymes were also measured. Using pre-weanling rats, brain GSH was depleted by up to 60% by subcutaneous administration of L-buthionine sulfoximine. The only enzyme affected by GSH depletion was glutathione reductase; its activity being reduced by approximately 40%. As GSH inactivates a number of oxidising species including peroxynitrite (ONOO-), we additionally investigated the susceptibility of glutathione reductase to ONOO- in vitro, using purified enzyme. ONOO- decreased glutathione reductase activity in a concentration dependent manner with an apparent 50% inhibition occurring at an initial concentration of 0.09 mM. These data suggest that GSH is important in the maintenance glutathione reductase activity. This may arise in part from its ability to inactivate oxidising agents such as ONOO-.