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81.
In dry coating processes no liquid, solvent, binder or water, is required. This makes them advantageous compared to wet coating alternative: being low cost, no drying step required, environmentally friendly (no volatile organic compounds related problems) and simple in operation. But there is still a lack of fundamental knowledge of the implied mechanisms. Often the process itself has been empirically designed and is not always well characterized.In this work, some hydrodynamic elements are developed in a high energy mixer used for dry coating: the specific behavior of the Nara hybridizer NHS-0 is investigated. In the first part, recirculation velocities and temperatures are derived during the process, or when the purge is on. The effects of the pressure purge and of the rotor velocity on the purge and the effect of the rotation on the temperature increase are studied. In the second part, a simple experimental approach is carried out to derive qualitatively the local temperature inside the apparatus with the help of polymers with different melting temperatures. This approach illustrates a first step for dry coating application with waxes. 相似文献
82.
Ali Alaeddine Cécile Genevois Laurence Chevalier Kaouther Daoud 《Nanoscale research letters》2011,6(1):1-11
Nanoscaled materials are attractive building blocks for hierarchical assembly of functional nanodevices, which exhibit diverse performances and simultaneous functions. We innovatively fabricated semiconductor nano-probes of tapered ZnS nanowires through melting and solidifying by electro-thermal process; and then, as-prepared nano-probes can manipulate nanomaterials including semiconductor/metal nanowires and nanoparticles through sufficiently electrostatic force to the desired location without structurally and functionally damage. With some advantages of high precision and large domain, we can move and position and interconnect individual nanowires for contracting nanodevices. Interestingly, by the manipulating technique, the nanodevice made of three vertically interconnecting nanowires, i.e., diode, was realized and showed an excellent electrical property. This technique may be useful to fabricate electronic devices based on the nanowires' moving, positioning, and interconnecting and may overcome fundamental limitations of conventional mechanical fabrication. 相似文献
83.
Laurence Lucchese Christopher M. Liauw Norman S. Allen Michele Edge Frank Thompson Robert S. Whitehouse 《Polymer Bulletin》2000,44(2):187-194
Summary
Microwave dielectric loss spectroscopy (MDS) has shown remarkable potential as a tool for the observation of changes in elastomer
network structure within the interphase region of natural rubber/ carbon black composites. During crosslinking (non elemental
sulphur system) the dielectric loss progressively increased. However, during ageing at high temperature the dielectric loss
decreased. Parallel studies on the unfilled matrix yielded no such variation in dielectric loss. It was therefore concluded
that the changes in microwave responses were related to the development of the interphase during curing and its subsequent
destruction during ageing. The microwave response was related to the composite mechanical properties as a function of ageing
time. The effect of stabiliser was also investigated.
Received: 13 September 1999/Revised version: 7 February 2000/Accepted: 10 February 2000 相似文献
84.
Laurence Moore 《Papers in Regional Science》1990,69(1):121-131
The understanding and modelling of consumer shopping behaviour can increasingly only be fully realised by reference to market segments. Disaggregate choice modelling methods are able to take account of such behavioural heterogeneity, but are hampered by the poor quality of observed choice data on which they are calibrated. This paper shows how a segmented modelling strategy may be developed using stated preference data, and illustrates the methodology using the example of grocery shopping in Cardiff, South Glamorgan. 相似文献
85.
Ghislain Oudinet Laurence Aufore Marie-Jeanne Gotta G. Chiarelli 《Journal of Nuclear Materials》2008,375(1):86-94
A better understanding of MOX fuel in-pile behaviour requires a very detailed characterization of the Pu distribution in the pellet before and after irradiation. Electron probe microanalysis (EPMA) can be used to determine the distributions of chemical elements with a spatial resolution of 1 μm. This paper describes the development of X-ray microanalysis techniques to produce semi-quantitative ‘maps’ of plutonium concentrations in order to rapidly characterize large areas of the fuel microstructure (1 mm2) with reasonable accuracy. A new segmentation technique based on statistical compatibility is then proposed, so as to finely describe the MIMAS MOX fuel microstructure. Two materials were finely characterized to demonstrate the reliability of this new method. In each case, the results demonstrate the good and reliable accuracy of this new characterization methodology. The analysis method used is currently able to identify three so-called phases (Pu-rich agglomerates, a coating phase and uranium-rich agglomerates), as well as to quantify the plutonium distribution and the plutonium content of these three phases. The impact of the fabrication process on the microstructure can be seen both in the surface distribution variations of the plutonium and in the local plutonium content variations. 相似文献
86.
Laurence E. Sheehan 《Information Systems Management》2000,17(3):1-12
When making the decision to hire one of several equally qualified candidates, IS managers fall back on their instincts and choose the candidate that “feels right.” They rely on personal chemistry, which is one of the variables in the hiring equation. Other equally important elements are: aptitude, attitude, and motivational factors. 相似文献
87.
Vicki L. Sauter Laurence A. Madeo 《Annals of Mathematics and Artificial Intelligence》1990,2(1-4):309-326
The user-acquainted feature collects user-specific data regarding the types of advice that have been sought over time and uses this historical information to update the probabilities to affect the firing of its rules and the ordering of the recommendations of the expert system. These updates are done on auser-specific basis so that the expert can more closely emulate a true expert by providing more informed advice. One example of a place where evidence suggests that such a feature would be useful is in the area of debugging of computer programs, especially in support of novice programmers who tend, as individuals, to commit similar classes of errors over time, but who, as a group, commit very different types of errors. We conjecture that the user-acquainted feature, which can keep track of the tendencies of the users and take them into account in the evaluation of diagnostics, will be more effectiveand efficient in determining the fault. In this paper, we discuss the statistical analyses necessary to implement this feature in an expert system for debugging errors in SAS. 相似文献
88.
Laurence Ponsonnet Mirela Boureanu Nicole Jaffrezic Ali Othmane Corinne Dorel Philippe Lejeune 《Materials science & engineering. C, Materials for biological applications》2008,28(5-6):896-900
The development of surface-associated layers of matrix-embedded microbial populations, called biofilms, is a serious problem in many medical and industrial settings. These contaminations are difficult to eradicate because of the high resistance level acquired by the cells in their particular environment. From the very beginning of the colonization process, modifications of gene expression are observed and could, at least partially, explain biofilm resistance. In order to develop anti-biofilm molecules and surface treatments, it is of pivotal importance to identify the physico-chemical parameters which activate the sensor systems of pioneering microbes when they come into contact with a surface. The aim of our study was to examine the pH variations in the local micro-environment created between the cell layer and the surface after bacteria adhesion. Using an ion-sensitive field effect transistor (ISFET), as a substratum, colonized by a curli hyperproducing strain known to form biofilms, we observed that the evolution of the pH change was significantly different in the micro-compartment in contact with the electrochemical sensor compared to that within the liquid phase. 相似文献
89.
Jean-Luc Loizeau Michel Pardos Fabrice Monna Christophe Peytremann Laurence Haller Janusz Dominik 《Lakes & Reservoirs: Research and Management》2004,9(1):53-63
The Bay of Vidy is the most contaminated area of Lake Geneva, Switzerland, as a result of the release of treated and untreated waste water from the municipal sewage treatment plant of the city of Lausanne and its surroundings. The reconstruction of the historical deposition of heavy metals in the sediment of the bay has been performed by the analysis of several dated (radiocaesium) sediment cores. The presence of sewage‐derived contaminants in the Bay of Vidy since the beginning of the sewage treatment plant's operations in 1964 is clearly observed, when a sharp increase in heavy metal contents is recorded, with maximum concentrations of cadmium, copper, zinc and lead occurring between the late 1960s and early 1970s. Despite considerable improvement in recent times, the present concentrations of the investigated heavy metals in sediments of the Bay of Vidy are still higher than concentrations measured at the centre of the lake, the latter close to Lake Geneva's natural background values. It is concluded that the quantity of heavy metals deposited in the bay is considerable and, because of sediment instability, will constitute a potential hazard for biota. 相似文献
90.
pH‐Cleavable Nucleoside Lipids: A New Paradigm for Controlling the Stability of Lipid‐Based Delivery Systems
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Dr. Khalid Oumzil Sébastien Benizri Giovanni Tonelli Dr. Cathy Staedel Ananda Appavoo Max Chaffanet Laurence Navailles Prof. Philippe Barthélémy 《ChemMedChem》2015,10(11):1797-1801
Lipid‐based delivery systems are an established technology with considerable clinical acceptance and several applications in human. Herein, we report the design, synthesis and evaluation of novel orthoester nucleoside lipids (ONLs) for the modulation of liposome stability. The ONLs contain head groups with 3′‐orthoester nucleoside derivatives featuring positive or negative charges. The insertion of the orthoester function in the NL structures allows the formation of pH‐sensitive liposomes. ONL‐based liposomes can be hydrolyzed to provide nontoxic products, including nucleoside derivatives and hexadecanol. To allow the release to be tunable at different hydrolysis rates, the charge of the polar head structure is modulated, and the head group can be released at a biologically relevant pH. Crucially, when ONLs are mixed with natural phosphocholine lipids (PC), the resultant liposome evolves toward the formation of a hexadecanol/PC lamellar system. Biological evaluation shows that stable nucleic acid lipid particles (SNALPs) formulated with ONLs and siRNAs can effectively enter into tumor cells and release their nucleic acid payload in response to an intracellular acidic environment. This results in a much higher antitumor activity than conventional SNALPs. The ability to use pH‐cleavable nucleolipids to control the stability of lipid‐based delivery systems represents a promising approach for the intracellular delivery of drug cargos. 相似文献