The Core Curriculum on Childhood Trauma: A tool for training a trauma-informed workforce.

Recognition of the nationwide high prevalence of psychological trauma in children and adolescents, combined with increasing awareness of the far-reaching adverse consequences of childhood trauma, have led to calls to develop a trauma-informed mental health workforce. We describe the initial pilot test of the Core Concepts portion of the Core Curriculum on Childhood Trauma, as conducted in a large graduate school of social work. The Core Curriculum uses detailed case vignettes of trauma-exposed youth and families, combined with problem-based learning methods, to promote two primary learning aims: (a) to enhance the development of foundational trauma-related conceptual knowledge, and (b) to accelerate the acquisition of trauma-informed clinical reasoning and clinical judgment. Vignettes are presented in segments to simulate gathering, organizing, drawing meaning from, and making decisions based on information in professional practice. After each segment, the facilitator helps learners to summarize relevant facts, develop hunches and hypotheses, identify learning issues, and plan next steps. The Curriculum was very favorably received by students and was associated with marked increases in self-efficacy in applying the Core Concepts to work with trauma-exposed youth and families. We discuss ways in which the Curriculum can be used, especially as a foundation for training in specific evidence-based treatment protocols, to help prepare a national mental health workforce capable of implementing trauma-informed evidence-based practice. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation

Phenotypic modulation of vascular smooth muscle cells plays an important role in the pathogenesis of arteriosclerosis. In a screen of proteins expressed in human aortic smooth muscle cells, we identified a novel gene product designated aortic carboxypeptidase-like protein (ACLP). The approximately 4-kilobase human cDNA and its mouse homologue encode 1158 and 1128 amino acid proteins, respectively, that are 85% identical. ACLP is a nonnuclear protein that contains a signal peptide, a lysine- and proline-rich 11-amino acid repeating motif, a discoidin-like domain, and a C-terminal domain with 39% identity to carboxypeptidase E. By Western blot analysis and in situ hybridization, we detected abundant ACLP expression in the adult aorta. ACLP was expressed predominantly in the smooth muscle cells of the adult mouse aorta but not in the adventitia or in several other tissues. In cultured mouse aortic smooth muscle cells, ACLP mRNA and protein were up-regulated 2-3-fold after serum starvation. Using a recently developed neural crest cell to smooth muscle cell in vitro differentiation system, we found that ACLP mRNA and protein were not expressed in neural crest cells but were up-regulated dramatically with the differentiation of these cells. These results indicate that ACLP may play a role in differentiated vascular smooth muscle cells.     

Decomposition theory for multidisciplinary design optimization problems with mixed integer quasiseparable subsystems

Numerous hierarchical and nonhierarchical decomposition strategies for the optimization of large scale systems, comprised of interacting subsystems, have been proposed. With a few exceptions, all of these strategies are essentially heuristic in nature. Recent work considered a class of optimization problems, called quasiseparable, narrow enough for a rigorous decomposition theory, yet general enough to encompass many large scale engineering design problems. The subsystems for these problems involve local design variables and global system variables, but no variables from other subsystems. The objective function is a sum of a global system criterion and the subsystems’ criteria. The essential idea is to give each subsystem a budget and global system variable values, and then ask the subsystems to independently maximize their constraint margins. Using these constraint margins, a system optimization then adjusts the values of the system variables and subsystem budgets. The subsystem margin problems are totally independent, always feasible, and could even be done asynchronously in a parallel computing context. An important detail is that the subsystem tasks, in practice, would be to construct response surface approximations to the constraint margin functions, and the system level optimization would use these margin surrogate functions. The present paper extends the quasiseparable necessary conditions for continuous variables to include discrete subsystem variables, although the continuous necessary and sufficient conditions do not extend to include integer variables.     

Assertion and defense mechanism preference.

Investigated the hypothesis that assertive and nonassertive individuals differ in the defense mechanisms they most typically rely on when confronted with interpersonal stress and conflict. The Defense Mechanism Inventory was administered to 40 undergraduates in 4 groups representing assertive and nonassertive males and females. As predicted, assertive Ss endorsed the most adaptive defense mechanism cluster of principalization (intellectualization, rationalization, isolation of affect), whereas nonassertive Ss endorsed the more primitive and socially ineffective defense mechanism clusters of turning against object and turning against self, respectively. Assertive Ss also demonstrated greater levels of intellectual achievement than their nonassertive peers, especially between the female groups. Recommendations are offered as to how these initial findings may contribute to a fuller understanding of assertive and nonassertive populations and how they may buttress existing assertion training strategies. (30 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Sequential sampling for contour estimation with concurrent function evaluations

We demonstrate the use of multiple surrogates and kriging believer for parallelizing surrogate-based contour estimation. For the demonstration example, we reduce wall clock time with minimal penalty in number of simulations.     

Superoxide production by macrophages stimulatedin vivo with synthetic ether lipids

The anticancer activity of synthetic ether lipids may depend in part upon their ability to activate cells of the monocyte/macrophage lineage. In the present study, we have sought to determine whether 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OMe) and related ether lipids enhance superoxide production by mouse peritoneal macrophages. Ether lipids were administered intraperitoneally to C57BL/6 mice 4 d after injection with thioglycollate broth. Elicited peritoneal macrophages were harvested and purified one day later, and superoxide production was detected by measuring the superoxide dismutase inhibitable reduction of cytochrome c. Low levels of superoxide were secreted by macrophages in the absence of phorbol 12-myristate 13-acetate (PMA). When PMA was addedin vitro to macrophages from ET-18-OMe-treated mice, these cells secreted 194.2 nmol superoxide/mg protein in comparison to 53.5 nmol superoxide/mg protein for PMA-treated control cells. Thein vitro treatment of the macrophages with ET-18-OMe was not effective in stimulating superoxide secretion. Macrophages harvested from mice treated with a series of ether lipids (with and without phosphorus) were examined, and superoxide secretion was found to vary with structure. AM-18-OEt and CP-7 were the most effective compounds, secreting 8.6 and 11.9 times more superoxide, respectively, than PMA-stimulated control cells. Moreover, direct cytotoxicity of the compounds for HL60 human promyelocytic leukemic cells did not necessarily correlate with the ability of each drug to increase macrophage superoxide production.     

Spline-based recognition of straight lines and curves in engineering line drawings

The paper addresses the problem of distinguishing straight lines from curves in noisy grey tone images and representing those lines and curves mathematically. A method for locating corners is discussed, and a technique based on spline representations is proposed for classifying line segments as straight or curved. Results are given for several typical noisy engineering line drawings.     

Variation in tannin activity of acorns of seven species of central florida oaks

Acorns of seven sympatric species of oaks (Quercus spp.) occurring in central Florida were compared for protein-precipitating ability (PPA). Husks and cotyledons of green and ripe acoms were analyzed. Few significant differences were found between green and ripe acorns of the same species. Cotyledons were significantly higher than husks in PPA in most of the species compared. All species exhibited high intraspecific variability in PPA. Significant differences between species were found in green and ripe cotyledons and in green husks. With the exception ofQ. minima, PPA of ripe cotyledons was higher in the subgenusErythrobalanus (red oaks) than the subgenusQuercus (white oaks).