The mechanics of spout-fluid beds at the minimum spout-fluid flowrate

Equations for predicting the minimum fluid flowrate in spout-fluid beds of coarse spherical particles are developed and experimentally verified. Correlations for the spout diameter and maximum spoutable height are also given. The annular pressure drop equations developed in previous work are experimentally verified.     

A methodological study of cigarette brand discrimination.

To test the comparative discriminability of the recognition judgment method and an affective (like-dislike) judgment method of brand discrimination, 246 regular cigarette smokers were divided into two groups, and each group member was given one of the 'Big Three' cigarettes with brand name obscured. Members of one group made a recognition judgment; members of the other made a 'like-dislike' judgment. Analysis of variance showed that (1) both types of judgment were made with better than chance accuracy, (2) the like-dislike judgment was slightly but not significantly more sensitive than the recognition judgment, (3) the distribution of responses for each type of judgment was radically different. "It was suggested that… the use of affective judgment… merits further study." (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A naturally occurring hPMS2 mutation can confer a dominant negative mutator phenotype

Defects in mismatch repair (MMR) genes result in a mutator phenotype by inducing microsatellite instability (MI), a characteristic of hereditary nonpolyposis colorectal cancers (HNPCC) and a subset of sporadic colon tumors. Present models describing the mechanism by which germ line mutations in MMR genes predispose kindreds to HNPCC suggest a "two-hit" inactivation of both alleles of a particular MMR gene. Here we present experimental evidence that a nonsense mutation at codon 134 of the hPMS2 gene is sufficient to reduce MMR and induce MI in cells containing a wild-type hPMS2 allele. These results have significant implications for understanding the relationship between mutagenesis and carcinogenesis and the ability to generate mammalian cells with mutator phenotypes.     

A model for the evaporation of water from large glass particles in pneumatic transport

A model is presented for the evaporation of water from large particles in pneumatic transport. The work is relevant for estimating the coating solution feed rate and the length of the draft tube in Wurster‐type particle coaters. Specifically, the rate of evaporation of water from 1 mm glass particles in a 28.45 mm tube was calculated from the model. The rate increased with solids mass flow rate, inlet air temperature and inlet particle temperature. The heat was more rapidly removed from the particle phase than from the air phase and high inlet air temperatures are tolerated. The model presupposes that the gas and particle velocities, and voidage are known and that the water film on a particle is thin and uniformly distributed. Hydrodynamic considerations that impact on the calculations are discussed.     

Corpus-based Learning of Analogies and Semantic Relations

We present an algorithm for learning from unlabeled text, based on the Vector Space Model (VSM) of information retrieval, that can solve verbal analogy questions of the kind found in the SAT college entrance exam. A verbal analogy has the form A:B::C:D, meaning “A is to B as C is to D”; for example, mason:stone::carpenter:wood. SAT analogy questions provide a word pair, A:B, and the problem is to select the most analogous word pair, C:D, from a set of five choices. The VSM algorithm correctly answers 47% of a collection of 374 college-level analogy questions (random guessing would yield 20% correct; the average college-bound senior high school student answers about 57% correctly). We motivate this research by applying it to a difficult problem in natural language processing, determining semantic relations in noun-modifier pairs. The problem is to classify a noun-modifier pair, such as “laser printer”, according to the semantic relation between the noun (printer) and the modifier (laser). We use a supervised nearest-neighbour algorithm that assigns a class to a given noun-modifier pair by finding the most analogous noun-modifier pair in the training data. With 30 classes of semantic relations, on a collection of 600 labeled noun-modifier pairs, the learning algorithm attains an F value of 26.5% (random guessing: 3.3%). With 5 classes of semantic relations, the F value is 43.2% (random: 20%). The performance is state-of-the-art for both verbal analogies and noun-modifier relations.Editors: Dan Roth and Pascale Fung     

Itk and Fyn make independent contributions to T cell activation

Itk is a member of the Btk/Tec/Itk family of nonreceptor protein tyrosine kinases (PTKs), and has been implicated in T cell antigen receptor (TCR) signal transduction. Lck and Fyn are the Src-family nonreceptor PTKs that are involved in TCR signaling. To address the question of how these members of different families of PTKs functionally contribute to T cell development and to T cell activation, mice deficient for both Itk and either Lck or Fyn were generated. The Itk/Lck doubly deficient mice exhibited a phenotype similar to that of Lck-deficient mice. The phenotype of the Itk/Fyn doubly deficient mice was similar to that of Itk deficient mice. However the Itk/Fyn doubly deficient mice exhibited a more severe defect in TCR-induced proliferation of thymocytes and peripheral T cells than did mice deficient in either kinase alone. These data support the notion that Itk and Fyn both make independent contributions to TCR-induced T cell activation.     

Pressure drop,bed expansion and liquid holdup in a three phase spouted bed contactor

Data on the pressure drop, bed expansion and liquid holdup in a three phase spouted bed contactor with an initial bed height of 243 mm. were obtained as a function of the gas and liquid flowrate. Polyethylene spheres 10 mm. in diameter with a density of 320 kg/m³ were spouted in a 194 mm. column using a 30 mm. nozzle. The spouted bed contactor with gas and liquid mass flow-rates of 2.18 and 1.88 kg/m² sec, respectively had similar pressure drop per unit area of particle surface, total liquid holdup per unit volume of operating bed, and “active” holdup, as a fluidized contactor.     

Flow in the annulus of a bed of fine particles spouted with water

The flow in the annulus of a water spouted bed of glass particles (275 to 774 μm) was studied experimentally in a cylindrical half-column 50.8 mm in diameter. An axisymmetric model, which assumes Darcy flow in the annulus and uses the experimental spout pressure distribution, predicts the flow and pressure fields in the annulus. The substantial differences between this flowfield and that for coarse particle beds that are observed are caused by differences in the normalized interfacial pressure profile. The model predicts that both the fluid velocity and the normalized fluid velocity at the top of the annulus decrease as the particle size and bed height are reduced. Particles are observed to enter the spout primarily near the spout inlet in agreement with predictions of the axial spout voidage distribution. The residence time distribution of the fluid in the annulus is relatively broad and the measured residence times are about 25% higher than those calculated.