Health and wellness monitoring through wearable and ambient sensors: exemplars from home-based care of elderly with mild dementia

Monitoring and timely intervention are extremely important in the continuous management of health and wellness among all segments of the population, but particularly among those with mild dementia. In relation to this, we prescribe three design principles for the construction of services and applications. These are ambient intelligence, service continuity, and micro-context. In this paper, we provide three exemplars from our research and development activities that illustrate the use of these design principles in the construction of services and applications. All the applications are drawn from the field of care for mild dementia patients in their living quarters.     

Program assists economic life determination

An interactive computer program is described for economic life determination using the revenue requirement technique. This program can also be used to compare different financial strategies.     

MIQR Active Learning on a Continuous Function and a Discontinuous Function

Active learning balances the cost of data acquisition against its usefulness for training. We select only those data points which are the most informative about the system being modelled. The MIQR (Maximum Inter-Quartile Range) criterion is defined by computing the inter-quartile range of the outputs of an ensemble of networks, and finding the input parameter values for which this is maximal. This method ensures data selection is not unduly influenced by ‘outliers’, but is principally dependent upon the ‘mainstream’ state of the ensemble. MIQR is more effective and efficient than contending methods¹ . The algorithm automatically regulates the training threshold and the network architecture as necessary. We compare active learning methods by applying them to a continuous function and a discontinuous function. Training is more difficult for a discontinuous function than a continuous function, and the volume of data for active learning is substantially less than for passive learning.     

évaluation de la validité théorique de l'Inventaire de l'organisation de la personnalité.

Studied the psychometric properties and the theoretical validity of the French translation of the Inventory of Personality Organization (IPO; O. F. Kernberg and J. F. Clarkin, 1995). The IPO was administered to 845 males and females from a Quebec university and from the general Quebec population. Separate exploratory and 1st-level confirmatory factor analyses were performed. The results indicate a good level of conformity between IPO items and the tridimensional primary constructs of O. F. Kernberg's theoretical model of personality organization. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Evaluation of FFT-Based and Moder Parametrc Methods for the Spectral Analysis of Bioprosthetic Valve Sounds

The objective of this paper is to compare the performance of conventional FFT-based (basic periodogram and Welch's method) and modern parametric (all-pole and pole-zero modeling) methods in estimating the spectral distribution of cardiac bioprosthetic valve sounds, and for the extraction of the two most dominant frequency peaks (DFP). These methods were tested for stability by adding random noise and truncating the bioprosthetic valve closing sounds, and for reproducibility by measuring the variance of the spectra obtained from three consecutive recordings of each patient. Results from a group of 11 patients show that the basic periodogram and Steiglitz-McBride's method with maximum entropy (pole-zero modeling) provide the most consistent (minimal variance) estimates of the DFP's of the closing sounds. However, for estimating spectral distributions, the most stable methods appear to be the basic periodogram and Steiglitz-McBride's method with extrapolation to zero. The basic periodogram appears to be the best compromise to estimate both the spectral distribution and the DFP's of the bioprosthetic closing sounds.     

Vaccination for experimental gliomas using GM-CSF-transduced glioma cells

Within the pituitary, folliculostellate (FS) cells are considered to regulate the intercellular communication between endocrine cells by paracrine mechanisms. One of the possible paracrine factors involved, could be interleukin-6 (IL-6) which is produced by these cells. Since IL-6 has been shown to be a growth factor of pituitary cells, we have determined whether IL-6 can also influence FS cell proliferation. To test this, a FS cell-like mouse pituitary cell line (TtT/GF cells) was used that exhibits most characteristics of normal FS cells. Under serum-free conditions the proliferation of TtT/GF cells is critically dependent on the initial seeding density: cells seeded at low density do not grow at all whereas cells seeded at high density proliferate with maximal doubling times of 34 hrs. Mouse IL-6 (mIL-6) stimulated only low density cell cultures in a dose and time dependent manner. For cells seeded at high density, exogenously added IL-6 may have failed to stimulate growth because of endogenously produced mIL-6. Conditioned medium from TtT/GF cells, in which mIL-6 concentrations up to 1017 pg/ml were measured, stimulated the proliferation of TtT/GF cells, indicating an autocrine growth stimulatory mechanism. A neutralizing mIL-6 antibody partially suppressed the growth of TtT/GF cells seeded at high density and partially reduced the growth stimulatory activity of TtT/GF conditioned medium. Thus, IL-6 is one but not the only factor that is involved in the autocrine growth stimulatory loop. The relevance of this mechanism for normal FS cells and its physiological consequence needs to be elucidated.     

Minnesota Multiphasic Personality Inventory T score conversion tables, 1957–1983.

Presents tables to facilitate the transformation of standard Minnesota Multiphasic Personality Inventory (MMPI) linear T score profiles to new MMPI normalized T score profiles (based on contemporary norms, as found by R. C. Collingan et al, 1983), and vice versa. These tables show that (1) the 1983 profiles are consistently less elevated than the corresponding 1957 profile presented by S. R. Hathaway and P. F. Briggs (see record 1959-01273-001) (if the latter are at or above T?=?50); (2) the more deviant a standard 1957 profile, the more this profile differs from its corresponding 1983 profile; and (3) the difference in elevation of 1983 and 1957 T scores for any fixed 1957 T score value varies across MMPI scales. Differences in elevations of 1957 and 1983 profiles of 20 or more T score points are possible when these profiles are generated from the same MMPI raw scores. Implications concerning false positive rates, false negative rates, and profile configurations are presented. (7 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)