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71.
Barnard Lucy; Stevens Tara; Siwatu Kamau Oginga; Lan William 《Canadian Metallurgical Quarterly》2008,1(3):169
A survey of a sample of faculty (N = 201) at a large, public university located in the Southwest was conducted to investigate whether differences in faculty attitudes toward diversity positively mediate faculty attitudes toward persons with disabilities. In addition, the current study examined whether differences in faculty attitudes toward diversity may be viewed as positively mediating the relationship between instructor characteristics and their attitudes toward persons with disabilities. This study concludes that faculty members may not be viewing disability as part of the greater construct of diversity with empirical evidence. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
72.
Where did that car come from?: Crossing the road when the traffic comes from an unfamiliar direction
Using a virtual road crossing environment, the reported research investigated the road crossing behavior of 12 male pedestrians in familiar and unfamiliar environments. Environment familiarity was manipulated using traffic direction. Seven of the participants were from a country where traffic flows from right to left and five were from countries were traffic flows from left to right. Each participant was asked to cross the road when traffic was coming from both the familiar and the unfamiliar direction for them. Results showed that pedestrians had lower safety ration, or a lower margin of error, in crossing the road when traffic was flowing in an unfamiliar direction, suggesting that pedestrians might be at greater risk of accident in such environments. Implications of these findings are discussed. 相似文献
73.
Lucy Bullivant 《Architectural Design》2005,75(1):38-45
Lucy Bullivant looks at the shape of the new office to come. With the onset of increasingly sophisticated communications devices, how is the organisation of space in our immediate working environments going to change? Will the lines between furniture and dynamic electronic devices simply blur? Will the structure of commercial office buildings themselves be required to become increasingly reflexive to meet environmental demands in the face of dwindling energy reserves? Or is the mobile nature of electronic communications actually in danger of rendering the permanent office as we know it extinct? Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
74.
境外建筑师事务所如何适应当前国内的建筑潮流并在其中有所作为?除了在方案竞赛中能展现具有“视觉震撼性”的透视效果图外,还要具备一套行之有效的设计管理系统。主要包括三方面内容:1.团队精神,2.各专业之间的协调,3.阶段性设计质量的保证。文章将就这三个内容展开讨论。 相似文献
75.
Overexpression of Tropomyosin Isoform Tpm3.1 Does Not Alter Synaptic Function in Hippocampal Neurons
Chanchanok Chaichim Tamara Tomanic Holly Stefen Esmeralda Paric Lucy Gamaroff Alexandra K. Suchowerska Peter W. Gunning Yazi D. Ke Thomas Fath John Power 《International journal of molecular sciences》2021,22(17)
Tropomyosin (Tpm) has been regarded as the master regulator of actin dynamics. Tpms regulate the binding of the various proteins involved in restructuring actin. The actin cytoskeleton is the predominant cytoskeletal structure in dendritic spines. Its regulation is critical for spine formation and long-term activity-dependent changes in synaptic strength. The Tpm isoform Tpm3.1 is enriched in dendritic spines, but its role in regulating the synapse structure and function is not known. To determine the role of Tpm3.1, we studied the synapse structure and function of cultured hippocampal neurons from transgenic mice overexpressing Tpm3.1. We recorded hippocampal field excitatory postsynaptic potentials (fEPSPs) from brain slices to examine if Tpm3.1 overexpression alters long-term synaptic plasticity. Tpm3.1-overexpressing cultured neurons did not show a significantly altered dendritic spine morphology or synaptic activity. Similarly, we did not observe altered synaptic transmission or plasticity in brain slices. Furthermore, expression of Tpm3.1 at the postsynaptic compartment does not increase the local F-actin levels. The results suggest that although Tpm3.1 localises to dendritic spines in cultured hippocampal neurons, it does not have any apparent impact on dendritic spine morphology or function. This is contrary to the functional role of Tpm3.1 previously observed at the tip of growing neurites, where it increases the F-actin levels and impacts growth cone dynamics. 相似文献
76.
S. Leane M.M. Herlihy F. Curran J. Kenneally N. Forde C.A. Simintiras R.G. Sturmey M.C. Lucy P. Lonergan S.T. Butler 《Journal of dairy science》2018,101(12):11285-11296
The objective of this study was to examine the effect of intravenous infusion of glucose on early embryonic development in lactating dairy cows. Nonpregnant, lactating dairy cows (n = 12) were enrolled in the study (276 ± 17 d in milk). On d 7 after a synchronized estrus, cows were randomly assigned to receive an intravenous infusion of either 750 g/d of exogenous glucose (GLUC; 78 mL/h of 40% glucose wt/vol) or saline (CTRL; 78 mL/h of 0.9% saline solution). The infusion period lasted 7 d and cows were confined to metabolism stalls for the duration of the study. Coincident with the commencement of the infusion on d 7 after estrus, 15 in vitro-produced grade 1 blastocysts were transferred into the uterine horn ipsilateral to the corpus luteum. All animals were slaughtered on d 14 to recover conceptuses, uterine fluid, and endometrial tissue. Glucose infusion increased circulating glucose concentrations (4.70 ± 0.12 vs. 4.15 ± 0.12 mmol/L) but did not affect milk production or dry matter intake. Circulating β-hydroxybutyrate concentrations were decreased (0.51 ± 0.01 vs. 0.70 ± 0.01 mmol/L for GLUC vs. CTRL, respectively) but plasma fatty acids, progesterone, and insulin concentrations were unaffected by treatment. Treatment did not affect either uterine lumen fluid glucose concentration or the mRNA abundance of specific glucose transporters in the endometrium. Mean conceptus length, width, and area on d 14 were reduced in the GLUC treatment compared with the CTRL treatment. A greater proportion of embryos in the CTRL group had elongated to all length cut-off measurements between 11 and 20 mm (measured in 1-mm increments) compared with the GLUC treatment. In conclusion, infusion of glucose into lactating dairy cows from d 7 to d 14 post-estrus during the critical period of conceptus elongation had an adverse impact on early embryonic development. 相似文献
77.
Abstract:This article presents a Commercial-Off-The-Shelf (COTS) evaluation and selection process that utilizes a weighted scoring model to facilitate the comparison of COTS components relative to a number of pre-established evaluation criteria. The application of a COTS evaluation methodology will enable project teams responsible for designing complex systems to take advantage of potential economic leverage and performance advantages COTS technology presents. More importantly, this approach provides a mechanism for careful evaluation of the candidate COTS components to ensure engineers developing COTS-intensive systems give appropriate consideration to critical COTS attributes such as operational requirements, risk, cost, technology maturity, and supplier viability. 相似文献
78.
John W. Parry Zhihong Cheng Jeffrey Moore Liangli Lucy Yu 《Journal of the American Oil Chemists' Society》2008,85(5):457-464
Cold-pressed seed flours from pumpkin, parsley, mullein, cardamom, and milk thistle were examined for total oil, fatty acid
profile of the oil, total phenolic content (TPC), scavenging activities against peroxyl (ORAC), hydroxyl (HOSC) and 2,2-diphenyl-1-picrylhydrazyl
(DPPH) (RDSC) radicals, and antiproliferative capacity against HT-29 human colon cancer cells. The cold-pressed parsley seed
flour contained a very high concentration of total oil—17.6 g/100 g flour—with primarily C18:1 fatty acid at 86.2 g/100 g
fatty acids. All other flour oils had relatively high levels of saturated fats, ranging from 39.0 to 62.9 g/100 g fatty acids.
The tested seed flours demonstrated significant TPC and free radical scavenging activities. Milk thistle seed flour had the
highest TPC value of 25.2 mg gallic acid equivalent per g flour (GAE mg/g) followed by that of parsley seed flour at 8.1 GAE
mg/g. Milk thistle seed-flour extract also had significantly higher antioxidant activities than all other extracts against
all tested radicals. The milk thistle seed-flour extract had an ORAC value of 1131 μmol trolox equivalents (TE) per g flour
(TE μmol/g), a HOSC value of 893 TE μmol/g, and an RDSC value of 61 TE μmol/g. Also, ORAC, HOSC, and TPC values were significantly
correlated (P < 0.01) under the experimental conditions. The cold-pressed milk thistle seed flour inhibited the proliferation of HT-29
cancer cells in a dose-dependent manner. Results from this study suggest that these cold-pressed seed flours may serve as
natural sources of antioxidants and may be used to improve human health. 相似文献
79.
An outbreak of waterborne cryptosporidiosis in a town in northern Sweden during winter 2010 resulted in the potential exposure of cured meat products to Cryptosporidium oocysts during their manufacture. The purpose of this work was to develop a method for analyzing cured meat products for contamination with Cryptosporidium oocysts and use this method to analyze potentially contaminated product samples. A simple method of elution, concentration, separation, and detection was used, based on work with other food matrices but adapted for the relatively high fat content of cured meat surfaces. Using spiking experiments, the recovery efficiency of this method was found to be over 60%. In the analysis of the potentially contaminated products, only one putative Cryptosporidium oocyst was detected, and this was sufficiently deformed so that it could not be confirmed as an oocyst; if it was an oocyst, it was considered to have been probably deformed and inactivated prior to analysis. Based on the results of the analyses, together with data on the probable extent of contamination of the products and on our knowledge of factors, such as water activity, which affect oocyst survival, the products were safely released to the market. 相似文献
80.
The growth of the necrotic core region within advanced atherosclerotic plaque is thought to be driven by oxidised low density
lipoprotein (oxLDL)-induced death of macrophage cells. OxLDL and atherosclerotic plaque are rich in oxysterols, especially
7-ketocholesterol (7KC). As 7KC triggers cell death at physiological concentrations when added directly to the cell culture
media, 7KC and other oxysterols have been suggested to be the main cytotoxic agent of oxLDL. We investigated this hypothesis
by examining the toxicity of 7KC to monocyte-like U937 cells when incorporated into high-uptake non-toxic acetylated LDL (acLDL).
Incorporation of 7KC into acLDL greatly reduced the oxysterol toxicity when compared with an equivalent amount of 7KC added
directly to U937 cells. Enrichment of oxLDL with 7KC did not significantly enhance lipoprotein toxicity. OxLDL was highly
cytotoxic yet generated only low levels of intracellular 7KC. In comparison, 7KC-acLDL generated high intracellular 7KC concentrations
with little loss in cell viability. The data show that when incorporated into lipoprotein, 7KC cytotoxicity is greatly reduced,
even though intracellular levels exceed those measured when cells are incubated with oxLDL, which suggests 7KC is not the
significant toxic agent within oxLDL. 相似文献