A Modular Vaccine Platform Combining Self‐Assembled Peptide Cages and Immunogenic Peptides

Subunit vaccines use delivery platforms to present minimal antigenic components for immunization. The benefits of such systems include multivalency, self‐adjuvanting properties, and more specific immune responses. Previously, the design, synthesis, and characterization of self‐assembling peptide cages (SAGEs) have been reported. In these, de novo peptides are combined to make hubs that assemble into nanoparticles when mixed in aqueous solution. Here it is shown that SAGEs are nontoxic particles with potential as accessible synthetic peptide scaffolds for the delivery of immunogenic components. To this end, SAGEs functionalized with the model antigenic peptides tetanus toxoid_632‐651 and ovalbumin_323‐339 drive antigen‐specific responses both in vitro and in vivo, eliciting both CD4⁺ T cell and B cell responses. Additionally, SAGEs functionalized with the antigenic peptide hemagglutinin_518‐526 from the influenza virus are also able to drive a CD8⁺ T cell response in vivo. This work demonstrates the potential of SAGEs to act as a modular scaffold for antigen delivery, capable of inducing and boosting specific and tailored immune responses.     

10Gb XFP光模块的电路板设计

XFP MSA(10Gb小形状因数可插拔多源协议)组织定义了用于数据通信和电信的10Gbps串行收发器,该组织由数据通信行业和电信行业中处于领先地位的网络公司、系统公司、光模块公司、半导体公司以及连接器公司组成(参考文献1).     

Design and fabrication of monolithically integrated DFB laser-wavelength duplexer transceivers for TPON/BPON access links

The fabrication and characterisation of monolithically integrated OEIC transceivers for use in optical subscriber access links are reported. A design incorporating DFB lasers, wavelength duplexers and a monitor photodiode, specific to the TPON/BPON passive optical network configuration is presented.<>     

CW high power single-lobed far-field operation of long-cavityAlGaAs-GaAs single-quantum-well laser diodes grown by MOCVD

Data on long-cavity 100-μm-wide broad-stripe laser diodes that lase with a barrow single-lobed far-field pattern in continuous room-temperature operation are presented. Diodes with a cavity length of 1250 μm emit a power of 200 mW per facet into a 2.5° lobe (full width at half maximum). Short-cavity devices (cavity length of 350 μm) lase with a continuously increasing number of lateral modes right from threshold, and exhibit a far-field divergence that is over three times greater than that of 1250-μm diodes. Explanations for the effect of increasing cavity length on the field patterns of these devices are proposed, based on the measured increase in injected carrier diffusion length in long-cavity diodes and the influence of thermal waveguiding and mirror losses on intermodel discrimination     

Performance Analysis of Integrated Voice and Data Hybrid-Switched Links

Numerical techniques for the solution of a class of twodimensional Markov processes are presented. These techniques are used to analyze the performance of several versions of hybrid switching including the movable boundary scheme with finite or infinite buffers, with flow control, and with or without TASI. Also included are results for TASI in which the number of off-hook calls is not fixed. Finally, the accuracy of the quasi-static approximation is evaluated for several problems.     

Detecting Low-Power RF Signals Using a Multimode Optoelectronic Oscillator and Integrated Optical Filter

We have assembled and characterized a multimode optoelectronic oscillator with integrated optical filter for detecting low-power radio-frequency (RF) signals. The system can selectively amplify RF signals from 1 to 6 GHz. The input signals can be as low as $-$ 83 dBm with a compression dynamic range of 72 dB. Using an integrated silicon optical filter facilitates channelization of the amplified RF signal from 1 to 3 GHz by reducing the gain for signals above 3 GHz. Future system improvements are discussed.      

Electrical characterization and modeling of alternating-currentthin-film electroluminescent devices

Electrical characterization of evaporated ZnS:Mn alternating-current thin-film electroluminescent (ACTFEL) devices is accomplished by capacitance-voltage (C-V) analysis. Interpretation of these C-V characteristics is aided by SPICE modeling and by electrical characterization of an ideal ACTFEL device constructed from discrete components, based on a simple equivalent circuit for the ACTFEL device. Various features of the C -V curve are ascribed to equivalent circuit parameters and associated device physics parameters     

Observation of photodetector nonlinearities

A heterodyne technique is used to characterise the nonlinear response behaviour of microwave pin photodetectors in terms of 3 dB bandwidth reduction and signal distortion of the sinusoidal input/output. Bandwidth reductions from 20 to 2.5 GHz (at 1.6 mW) are observed.<>     

Characterization of ZnS grown by metal-organic chemical vapour deposition on GaAs(100) using t-butyl mercaptan and dimethylzinc

ZnS has been grown on GaAs(100) substrates by atmospheric pressure metal–organic chemical vapour deposition (MOCVD) using dimethylzinc (DMZn) and t-butyl mercaptan (t-BuSH). The effects of the reactant gas phase molar ratio and the growth temperature on the characteristics of the material grown have been investigated. The structural quality of the layer is demonstrated by X-ray rocking curve half-widths of less than 300 arcsec for the epilayers. There is little significant pre-reaction and the layers are of excellent surface morphology and layer uniformity.     

用于电源、继电器和螺线管的协同式线路保护

在各种新型先进设备上实施协同式电路保护可有助于提高设备可靠性、减少元器件数量,并使其符合严格的安规要求。协同式方法能够帮助保护电源、继电器和螺线管,避免因线路故障或过载造成电流增大以及尖峰电压或暴露在稳态过压状态带来的危害。