An investigation of the criterion problem for one group of medical specialists.

The sample consisted of 190 Utah physicians fully certified as specialists by an American Board. 80 scores relevant to the performance of these physicians were intercorrelated and factor analyzed using the principal components solution based on eigenvalues and eigenvectors. The 29 factors which had an eigenvalue greater than 1.00 were rotated by the varimax procedure and interpreted. The most important finding was the great criterion complexity for this group of medical specialists. This complexity suggests that one cannot adequately measure physician performance on the basis of a single score or a few scores. Instead, one must obtain a relatively large number of scores. Performance in poth premedical and medical education was independent of performance as a physician. (19 ref.) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Biosynthesis and subcellular localization of histamine in H-110 lymphoma

The histidine decarboxylase activity has been studied in the H-110 Lymphoma implanted in Balb-c mice. The enzymatic activity has been determined using DL-Histidine 1-14C by measuring the I--14CO2 liberated during the incubation. It has been found that the histidine decarboxylase activity in the tumor is the highest of the studied tissues. The pretreatment for 5 days with two cytostatic drugs, cyclophosphamide and 5-fluoruracile, determined a decrease of the enzymatic activity in the tumor of 33 and 54 per cent, respectively. This effect has not been observed in the lung. The pretreatment of the animals during 10 days with 0.1 mg per kg body of histamine, which in other experimental tumors induces an increase of the endogenous content of histamine, produces a decrease of the tumoral histidine decarboxylase activity. The histamine-14C uptake was not modified by this pretreatment. The subcellular localization of the radioactivity after pretreatment with histamine-14C evidenced that the nuclear fraction of the tumor contained between 2 and 10 times the radioactivity of other tissues of the same animal.