Prophylactic efficacy of tilmicosin for bovine respiratory tract disease

The prophylactic administration of injectable tilmicosin for pneumonia in weaned beef calves was investigated in 1,806 animals. Comparisons were made among calves receiving an "on-arrival" injection of tilmicosin, calves receiving a single injection of long-acting oxytetracycline, and calves receiving no prophylaxis. Morbidity and mortality attributable to pneumonia, morbidity and mortality attributable to all causes, and case fatality were significantly lower in the group of calves that received tilmicosin, compared with calves that received long-acting oxytetracycline and calves that received no prophylactic antibiotic. Mean time to initial pneumonia treatment was significantly extended in calves that received prophylaxis, compared with those that received no antibiotic on arrival at the feedlot. Calves that received tilmicosin gained significantly more weight than calves that received oxytetracycline. Calves that were not treated for pneumonia during the trial period gained significantly more weight than did those calves that were treated for pneumonia regardless of experimental group. The majority of mortalities were attributable to fibrinous pneumonia (31/34). Important bacterial isolates (Pasteurella spp, Haemophilus somnus, Actinomyces pyogenes) obtained at necropsy did not have resistance to tilmicosin in association with administration of tilmicosin as prophylaxis for pneumonia. However, bacterial resistance to trimethoprim/sulfonamide and to oxytetracycline were commonly found in these postmortem isolates.     

Anion modulation of taste responses in sodium-sensitive neurons of the hamster chorda tympani nerve

Beidler's work in the 1950s showed that anions can strongly influence gustatory responses to sodium salts. We have demonstrated "anion inhibition" in the hamster by showing that the chorda tympani nerve responds more strongly to NaCl than to Na acetate over a wide range of concentrations. Iontophoretic presentation of Cl- and acetate to the anterior tongue elicited no response in the chorda tympani, suggesting that these anions are not directly stimulatory. Drugs (0.01, 1.0, and 100 microM anthracene-9-carboxylate, diphenylamine-2-carboxylate, 4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonate, and furosemide) that interfere with movements of Cl- across epithelial cells were ineffective in altering chorda tympani responses to 0.03 M of either NaCl or Na acetate. Anion inhibition related to movements of anions across epithelial membranes therefore seems unlikely. The chorda tympani contains a population of nerve fibers highly selective for Na+ (N fibers) and another population sensitive to Na+ as well as other salts and acids (H fibers). We found that N fibers respond similarly to NaCl and Na acetate, with spiking activity increasing with increasing stimulus concentration (0.01-1.0 M). H fibers, however, respond more strongly to NaCl than to Na acetate. Furthermore, H fibers increase spiking with increases in NaCl concentration, but generally decrease their responses to increasing concentrations of Na acetate. It appears that anion inhibition applies to taste cells innervated by H fibers but not by N fibers. Taste cells innervated by N fibers use an apical Na+ channel, whereas those innervated by H fibers may use a paracellularly mediated, basolateral site of excitation.     

The development of sibling relationships in infancy: a short-term longitudinal study

24 infants and their preschool-aged siblings were observed in a laboratory playroom in the presence of their parents. Observations took place when the infants were 12 months old and again 6 months later. Analysis of the social behavior revealed that, at both ages, the children assumed differentiable roles in their interactions: The infants "followed" by observing and imitating while the preschoolers "led" by drawing the infants' attention and by assertive dominance. Over time, infants became increasingly willing to direct social behaviors toward their siblings. There was remarkable behavioral stability across time, with the infants' early propensities seemingly causally related to later pre-schoolers' behavior. Older girls directed more social behaviors to siblings than boys did. The amount of parent-directed behavior was affected by the number of adults present, whereas the amount of sibling-directed behavior was unaffected.     

Computing the homology of groups: The geometric way

In this paper, we present several algorithms related with the computation of the homology of groups, from a geometric perspective (that is to say, carrying out the calculations by means of simplicial sets and using techniques of Algebraic Topology). More concretely, we have developed some algorithms which, making use of the effective homology   method, construct the homology groups of Eilenberg–MacLane spaces K(G,1)$K(G,1)$ for different groups G$G$, allowing one in particular to determine the homology groups of G$G$.     

Modeling of the relative humidity via functional networks and control of the temperature via classic controls for a bird incubator

The control of the relative humidity and the temperature is important for the birds to be born. It is not easy to control the relative humidity, but it is possible to obtain the measure of the relative humidity as a consequence of the control of the temperature in a bird incubator. In this article, (1) the mathematical model for the control of temperature in the bird incubator is presented, (2) a functional network to approximate the relative humidity behavior in the bird incubator is proposed, (3) a control for the temperature in the bird incubator is proposed, the error of the proportional control applied to the mathematical model of the temperature of the bird incubator is assured to be uniformly stable, (4) the comparison results of four classic control laws for the control of the temperature considering the proposed mathematical model of the temperature and the functional network to approximate the relative humidity behavior in the bird incubator are presented.     

The turnover and distribution of labelled corticosterone during post-natal development of the duckling (Anas platyrhynchos)

During 6 months of post-natal development in the laboratory, the weight of the adrenal gland relative to body weight decreases exponentially. In the 3 day-old duckling a single intravenous dose of labelled corticosterone becomes distributed in a very large apparent volume and an "extracellular" pool that is greater than the extracellular fluid volume and the pattern of disappearance of labelled hormone from plasma is biphasic. Later during development the volumes of distribution decrease and the biphasic pattern of disappearance becomes less distinct until at 6 months only one phase of disappearance can be detected with confidence. No significant change in plasma corticosterone concentration occurs during this period of development in the laboratory. Estimations of the corticosterone secretory rates, however, indicate that whereas the adrenal weight-specific rate os secretion increases during the first 3 weeks and declines therafter, the bodyf weight-specific secretory rate continues to decline throughtout the period of increasing body weight.     

Fatigue damage accumulation of cold expanded hole in aluminum alloys subjected to block loading

Fatigue damage accumulation of cold expanded hole in aluminum alloys used in land transportation components was investigated. Tests were carried out using pre-cracked SENT specimens and inserting an expanded hole at the crack tip. The degree of the cold expansion was chosen equal to 4.3%. Tests were performed in two and four block loading under constant amplitude. Two sequences were compared.The increasing and the decreasing magnitude were compared. The experimental results were compared to the damage calculated by the Miner's rule and a new simple fatigue damage indicator. This comparison shows that the ‘model of the damage stress’, which take into account of the loading history, yields a good estimation of the experimental results. Moreover, the error is minimized in comparison to the Miner's model.     

对一次高频保护跳闸事故的分析

在一次系统故障过程中。输电线路的两套高频保护装置CSL-101B型和LFP-901B型动作行为不一致。本文就此展开分析，以达到正确理解两种保护动作行为的目的。并对加强高频保护的现场管理提出意见。     

Analysis of inorganic anions in drainage water and soil solution by single-column ion chromatography

Single-column ion chromatography (SCIC) for anion determination in drainage water and soil solution was tested. The SCIC minimum detection limits (100-microliter sample loop) were 0.75 mg l-1 for Cl-, 0.2 mg l-1 for NO2-N, 0.02 mg l-1 for NO3-N, 1.25 mg l-1 for HPO4-P, and 0.5 mg l-1 for SO4-S. The results showed a high reproducibility. Results for Cl-, NO3-N and SO4-S obtained by the SCIC method were compared with those obtained by traditional methods; Student's t-test and regression analysis showed that the methods agree closely.