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61.
A 74-year-old patient sought treatment for visual obscuration and clinically had signs of Graves orbitopathy. Past medical history was unremarkable except for the use of antihypertensive medication. During the hospital admission, a fluorescent treponemal antibody absorption test was reactive, indicating infection with syphilis at some time in the past. Visual deterioration despite oral corticosteroid therapy prompted orbital decompression. At the time of surgery, she sustained a globe rupture. Presumably, syphilitic scleritis was responsible, in part, for scleral thinning and weakening, predisposing her to this complication. To the authors' knowledge, globe rupture has not been previously reported during orbital decompression. 相似文献
62.
J Sayos C Wu M Morra N Wang X Zhang D Allen S van Schaik L Notarangelo R Geha MG Roncarolo H Oettgen JE De Vries G Aversa C Terhorst 《Canadian Metallurgical Quarterly》1998,395(6701):462-469
In addition to triggering the activation of B- or T-cell antigen receptors, the binding of a ligand to its receptor at the cell surface can sometimes determine the physiological outcome of interactions between antigen-presenting cells, T and B lymphocytes. The protein SLAM (also known as CDw150), which is present on the surface of B and T cells, forms such a receptor-ligand pair as it is a self-ligand. We now show that a T-cell-specific, SLAM-associated protein (SAP), which contains an SH2 domain and a short tall, acts as an inhibitor by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the SLAM cytoplasmic region. The gene encoding SAP maps to the same area of the X chromosome as the locus for X-linked lymphoproliferative disease (XLP) and we found mutations in the SAP gene in three XLP patients. Absence of the inhibitor SAP in XLP patients affects T/B-cell interactions induced by SLAM, leading to an inability to control B-cell proliferation caused by Epstein-Barr virus infections. 相似文献
63.
KK Khurana MG Kivelson DJ Stevenson G Schubert CT Russell RJ Walker C Polanskey 《Canadian Metallurgical Quarterly》1998,395(6704):777-780
The Galileo spacecraft has been orbiting Jupiter since 7 December 1995, and encounters one of the four galilean satellites-Io, Europa, Ganymede and Callisto-on each orbit. Initial results from the spacecraft's magnetometer have indicated that neither Europa nor Callisto have an appreciable internal magnetic field, in contrast to Ganymede and possibly Io. Here we report perturbations of the external magnetic fields (associated with Jupiter's inner magnetosphere) in the vicinity of both Europa and Callisto. We interpret these perturbations as arising from induced magnetic fields, generated by the moons in response to the periodically varying plasma environment. Electromagnetic induction requires eddy currents to flow within the moons, and our calculations show that the most probable explanation is that there are layers of significant electrical conductivity just beneath the surfaces of both moons. We argue that these conducting layers may best be explained by the presence of salty liquid-water oceans, for which there is already indirect geological evidence in the case of Europa. 相似文献
64.
Hemispheric contributions to the integration of visual and auditory information in speech perception
Differential hemispheric contributions to the perceptual phenomenon known as the McGurk effect were examined in normal subjects, 1 callosotomy patient, and 4 patients with intractable epilepsy. Twenty-five right-handed subjects were more likely to demonstrate an influence of a mouthed word on identification of a dubbed acoustic word when the speaker's face was lateralized to the LVF as compared with the RVF. In contrast, display of printed response alternatives in the RVF elicited a greater percentage of McGurk responses than display in the LVF. Visual field differences were absent in a group of 15 left-handed subjects. These results suggest that in right-handers, the two hemispheres may make distinct contributions to the McGurk effect. The callosotomy patient demonstrated reliable McGurk effects, but at a lower rate than the normal subjects and the epileptic control subjects. These data support the view that both the right and left hemisphere can make significant contributions to the McGurk effect. 相似文献
65.
Dickinson CE Campion K Foster AF Newman SJ O'Rourke AM Thomas PG 《Applied ergonomics》1992,23(3):197-201
This paper describes the outcome of user trials of the Nordic Musculoskeletal Questionnaire which encompassed the views of the following groups: data entry clerks, technical staff, administrative clerks and 481 subjects employed in 10 supermarkets. A significant number of improvements was identified, especially concerning its wording, layout and administration. This has led to a standardized version being produced for use in studying the prevalence of reported symptoms in many types of occupational groups. 相似文献
66.
Cellulose acetate carbamates (CACs) are the polymers which result when organic isocyanates are reacted with the free hydroxyl groups of cellulose acetate (CA). CACs are more hydrolytically stable and exhibit physical properties which are superior to those of their CA mixed ester analogs. Two synthetic approaches to CACs have been utilized in this study: (1) preformation, i.e., separate synthesis of such polymers prior to their inclusion in solutions for membrane casting; and (2) in situ formation, i.e., the inclusion of blocked isocyanates in standard dry process casting solutions of CA followed by thermal activation of the resultant dry membranes leading to regeneration of free isocyanate and subsequent CAC formation. Preformed CAC polymers have been prepared utilizing phenyl-, 3-chloropropyl-, 3-bromopropyl-, and 3-bromopropyl-(isothio)-, isocyanates. Polymers containing omega-halocarbamate moieties were quaternized with dimethylbenzylamine to produce ionogenic (QCAC) polymers containing quaternary ammonium groups. DRY-RO membranes from the QCACs exhibit flux/rejection values varying between 6–8 gfd at 98% rejection and 20 gfd at 90% rejection (0.5% NaCl feed at 400 psi and 25°C). In situ formation of CAC membranes has been effected with tolylene- and hexamethylene-diisocyantes, with quaternized isocyanate monomers employed for the preformed CAC polymers, and with specially tailored diisocyanates containing ionogenic groups. Crosslinking rendered all of the membranes acetone insoluble. Inasmuch as in situ formation substitutes the easy synthesis of blocked isocyanate monomers for the more difficult separate synthesis of preformed CAC polymers, it is anticipated that the former will replace the latter. 相似文献
67.
Potentiostatic scratching experiments have been carried out on copper and 70-30 brass electrodes in acid and neutral electrolytes. The results are compared with published measurements of stress corrosion crack velocities in α-brass in neutral ammoniacal solutions. The plateau crack velocity at low strain-rates can be accounted for by stoichiometric bare surface oxidation of the alloy components, but at high strain-rates it is necessary to invoke rapid bare surface dezincification. Charge analysis shows that zinc dissolution can occur from several alloy layers at > 5 A cm?2 without appreciable anodic reaction of copper. Some features of the bare surface electrochemistry of copper are discussed. 相似文献
68.
S.T. Newman A. Nassehi X.W. Xu R.S.U. Rosso Jr. L. Wang Y. Yusof L. Ali R. Liu L.Y. Zheng S. Kumar P. Vichare V. Dhokia 《Robotics and Computer》2008
In the domain of manufacturing, computer numerically controllers (CNC) technology is a major contributor to the production capacity of the enterprises. The advances in CNC technology coupled with enhancements in computing systems have provided the basis to re-examine the way in which computer-aided systems (CAx) can be used to enable global manufacturing. Interoperability of the various components of the CAx chain is therefore a major prerequisite for manufacturing enterprises for becoming strategically agile and consequently globally competitive. Being interoperable, resources can be utilized interchangeably in a plug-and-produce manner. Over the last 8 years the eminence of a STEP standard for machining entitled STEP-NC (numerical control) has become a well-known vehicle for research to improve the level of information availability at the CNC machine tool. In this paper, the authors introduce the background to the evolution of CNC manufacturing over the last 50 years and the current standards available for programming. A review of the literature in interoperable CNC manufacturing is then provided relating to milling, turn–mill and other NC processes. The major part of the paper provides a strategic view of how interoperability can be implemented across the CAx chain with a range of standards used to regulate the flow of information. Finally, the paper outlines the advantages and major issues for future developments in interoperability, identifying future key requirements and limiting factors. 相似文献
69.
RD Jones AR Visram JP Kornberg MG Irwin WM Gunawardene 《Canadian Metallurgical Quarterly》1994,22(5):539-544
We studied 30 children, aged 4 to 12 years, undergoing elective circumcision, premedicated with midazolam 0.5 mg.kg-1 and atropine 0.02 mg.kg-1 by mouth. A modified postbox test and the coding component of the Wechsler intelligence scale (WISC-R) was used to assess the preoperative effect of premedication on psychomotor function. Mood and sedation were also scored and related to serum midazolam concentrations. The children showed a significant decline in psychomotor performance 30 and 60 minutes after premedication when compared with their best unmedicated performance recorded the previous evening. This decline in psychomotor performance was only weakly associated with serum midazolam concentrations (r = 0.1). The postbox toy ratio is a suitable measurement of psychomotor performance in children because of its simplicity and ease of use in the clinical environment, although it may suffer the "test-retest" limitations of similar types of assessment. The sedative and anxiolytic effects of midazolam provide a quiet environment for a smooth induction of anaesthesia. 相似文献
70.