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151.
Judgements of overall seating comfort in dynamic conditions sometimes correlate better with the static characteristics of a seat than with measures of the dynamic environment. This study developed qualitative models of overall seat discomfort to include both static and dynamic seat characteristics. A dynamic factor that reflected how vibration discomfort increased as vibration magnitude increased was combined with a static seat factor which reflected seating comfort without vibration. The ability of the model to predict the relative and overall importance of dynamic and static seat characteristics on comfort was tested in two experiments. A paired comparison experiment, using four polyurethane foam cushions (50, 70, 100, 120 mm thick), provided different static and dynamic comfort when 12 subjects were exposed to one-third octave band random vertical vibration with centre frequencies of 2.5 and 5.5 Hz, at magnitudes of 0.00, 0.25 and 0.50 m x s(-2) rms measured beneath the foam samples. Subject judgements of the relative discomfort of the different conditions depended on both static and dynamic characteristics in a manner consistent with the model. The effect of static and dynamic seat factors on overall seat discomfort was investigated by magnitude estimation using three foam cushions (of different hardness) and a rigid wooden seat at six vibration magnitudes with 20 subjects. Static seat factors (i.e. cushion stiffness) affected the manner in which vibration influenced the overall discomfort: cushions with lower stiffness were more comfortable and more sensitive to changes in vibration magnitude than those with higher stiffness. The experiments confirm that judgements of overall seat discomfort can be affected by both the static and dynamic characteristics of a seat, with the effect depending on vibration magnitude: when vibration magnitude was low, discomfort was dominated by static seat factors; as the vibration magnitude increased, discomfort became dominated by dynamic factors. 相似文献
152.
Static seat characteristics (seat stiffness) and dynamic seat characteristics (vibration magnitude) can both influence judgements of seat comfort. It is proposed that seat comfort can be predicted on the basis of Steven's psychophysical law: psi = kphi(n), where psi is a sensation magnitude, phi is the stimulus magnitude and k is a constant. The law is modified to: psi = a + bphis[n(s)] + cphiv[n(v)], where phis and phiv represent seat stiffness and vibration magnitude, n(s) and n(v) are exponents determined by the rate of increase in discomfort associated with the stiffness and vibration magnitude, and a, b and c are constants. The stiffness of foam loaded to 490 N may indicate static seat comfort, while the vibration dose value (VDV) on the seat surface may indicate vibration discomfort. Two experiments with 20 subjects investigated this approach. The first experiment with five magnitudes of vibration, three foams and a rigid wooden flat seat yielded 0.929 for the exponent, n(v), for VDV. In the second experiment subjects judged the overall seat discomfort while exposed six vibration magnitudes with the same four seating conditions. This experiment yielded 1.18 for the exponent, n(s), for seat stiffness. The overall prediction of seat discomfort was given by: psi = -50.3 + 2.68phis1.18 + 101phiv0.929. The prediction equation provided more accurate estimates of subject discomfort than models using either the VDV alone or the stiffness alone, especially when the vibration magnitude was low or the seats were similar. An interaction variable between the VDV and the stiffness slightly improved the prediction. The equivalence of the two stimuli was given by log10 (stiffness) = 0.787 log10 (VDV) + 1.34, or log10 (VDV) = 1.27 log10 (stiffness) - 1.70. 相似文献
153.
Hernández LM Gómara G Fernández M Jiménez B González MJ Baos R Hiraldo F Ferrer M Benito V Suñer MA Devesa V Muñoz O Montoro R 《The Science of the total environment》1999,242(1-3):293-308
The impact of the spill from the mine in Aznalcollar (Seville, Spain) on waterfowl in the Do?ana National Park is assessed. The concentrations of Cu, Pb, Cd, Zn nd As in the liver and eggs of 16 species of waterfowl found dead in the Park between April and November 1998 were determined. The highest levels were found for Zn, followed by Cu, Pb, Cd and As. The main parameters related to the accumulation of these elements in the waterfowl studied were species and trophic level. The other variables studied--distance from the spill, days of exposure, sex, size, and age--are important, although this depends on the element studied. Zn and Cu from the spill have entered the food chain of the aquatic birds studied, but Cd, Pb and As have not. There is currently no evidence to suggest that the trace element concentrations measured have reached toxic levels. 相似文献
154.
Aromatic sulfonates (AS) are large-volume chemicals used in many technical processes of, for instance, the textile industry or construction. A LC/MS method for the selective determination of AS in environmental samples, based on a single-quadrupole MS, was developed and validated. The central point of this technique is the use of the compound-specific fragment ion SO3.- as marker for aromatic sulfonates. This negatively charged SO3 radical, together with the fact that AS undergo loss of SO2, allows screening for AS in complex matrixes, even in the presence of sulfate anions. Calibration curves generated from LC/MS data showed good linearity over 3 orders of magnitude, with an absolute limit of detection of approximately 1 ng. The relative standard deviation for mean areas obtained from reconstructed ion chromatograms ranged from 2.9 to 8.6%. Unlike UV detection, this LC/MS method gives similar response for both naphthalene- and benzene-sulfonates. The method presented was successfully applied to landfill leachates and groundwater, downstream of a landfill. Furthermore, this technique allowed identification of an unknown AS found in drain samples. 相似文献
155.
A supercritical fluid chromatograph was previously interfaced to a mass spectrometer (SFC/MS) and the system evaluated for applications requiring high sample throughput using negative-mode atmospheric-pressure chemical ionization (APCI) (Ventura et al. Anal. Chem. 1999, 71, 2410-2416). This report extends the previous work demonstrating the effectiveness of SFC/MS, using positive ion APCI for the analysis of compounds with a wide range of polarities. Substituting SFC/MS for LC/MS results in substantial time saving, increased chromatographic efficiency, and more precise quantitation of sample mixtures. Flow injection analysis (FIA) also benefits from our SFC/MS system. A broader range of solvents is compatible with the SFC mobile phase compared with LC/MS, and solutes elute more rapidly from the SFC/MS system, reducing sample carryover and cycle time. Our instrumental setup also allows for facile conversion between LC/MS and SFC/MS modes of operation. 相似文献
156.
A method for the unambiguous determination of 41 key polychlorinated biphenyls (PCBs) (including coplanar and chiral congeners) and the enantiomeric ratio of chiral congeners is described. The method includes a fractionation step using a 2-(1-pyrenyl) ethyldimethylsilylated silica column for separating the polychlorinated biphenyls according to the number of chlorine atoms in the ortho positions. High-resolution gas chromatography with an electron capture detector and an achiral column was used to determine the PCB congener content in each fraction. The enantiomeric ratio of chiral congeners was calculated by high-resolution gas chromatography with a mass spectrometry detector using a chiral column. The method was found to be inexpensive, rapid, effective, and reliable under the operational conditions proposed. It eliminates the main coelution problems among the polychlorinated biphenyl congeners. It also makes it possible to determine the enantiomeric ratio of nine chiral congeners using monodimensional gas chromatography. The method was applied successfully to the analysis of the coplanar and atropisomeric polychlorinated biphenyl congeners in dolphin liver samples. The enantiomeric ratio of nine chiral congeners is also reported for the first time. 相似文献
157.
Kelly RM Meyer JD Matsuura JE Shefter E Hart MJ Malone DJ Manning MC 《Drug development and industrial pharmacy》1999,25(1):15-20
For certain patients who experience intense vertigo arising from unilateral vestibular lesions, the primary therapy is a vestibular nerve section, an intracranial surgical procedure. One alternative to this treatment is therapeutic ablation of vestibular function on the unaffected side using an ototoxic agent. We prepared a biodegradable sustained-release gel delivery system using sodium hyaluronate that can be administered into the middle ear using only a local anesthetic. The gel contains gentamycin sulfate, the ototoxic agent of choice for treatment of unilateral vestibulopathy, and it exhibits diffusion-controlled release of the drug over a period of hours. The released gentamycin could then diffuse into the inner ear through the round membrane. This represents an important advance over previous formulations, which used only gentamycin sulfate solutions, in that it should allow more careful control of the dose, it should reduce loss of the drug from the middle ear site, and it should maintain intimate contact with the round membrane. By carefully controlling the dose, it should be possible to inhibit vestibular function while minimizing hearing loss. Herein we describe the in vitro release kinetics of gentamycin sulfate from sodium hyaluronate gels and find that the system obeys Fickian behavior. 相似文献
158.
Study of the binding in an aqueous medium of inclusion complexes of several cyclodextrins involving fenoprofen calcium 总被引:1,自引:0,他引:1
Díaz D Escobar Llanos CM Bernad Bernad MJ 《Drug development and industrial pharmacy》1999,25(1):107-110
Interactions among fenoprofen calcium and alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) were evaluated in aqueous solution by UV/vis and fluorescence direct spectroscopies and monodimensional (1D) 1H-NMR. Different UV/vis and fluorescence emission spectra were obtained to study the apparent binding constants (K) to define the most appropriate cyclodextrin to form the inclusion complexes (IC). beta-CD and HP-beta-CD clearly fit the magnitude of stability constant data of the complexes to take into account the pharmaceutical technology interest. 相似文献
159.
D'Souza MJ Oettinger CW Shah A Tipping PG Huang XR Milton GV 《Drug development and industrial pharmacy》1999,25(5):591-596
A macrophage plays an important role in mediating the inflammatory response. Cytokines released by activated macrophages contribute to inflammation in glomerulonephritis (GN). Clodronate, a biphosphonate, causes macrophage depletion when administered in an encapsulated form in liposomes. We used albumin as the polymer matrix to microencapsulate clodronate to the microspheres (MS) in the 1-micron size range. The purpose of this study was to (a) determine macrophage depletion by clodronate MS, (b) determine the effect of clodronate MS on endotoxin-induced cytokine release in vitro, and (c) assess the effect of clodronate MS on macrophage infiltration in experimental antiglomerular basement membrane nephritis. Macrophage depletion by clodronate MS was assessed by staining for the EDI marker. The results indicate greater than 95% depletion of macrophages from the spleen, liver, kidney, and blood. In the whole blood model, clodronate MS attenuated endotoxin-induced tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) release, and the attenuation by the microencapsulated form of clodronate was also more effective than the free (solution) form of clodronate. Macrophage infiltration into the glomerulus in experimental GN was also blocked very effectively by pretreatment with clodronate MS. In conclusion, macrophage depletion by clodronate MS may be beneficial in reducing cytokine release and renal damage in GN. 相似文献
160.
Recent studies indicate potential links among work organization, job stress, and work-related musculoskeletal disorders (WRMDs). In this paper we propose several pathways for a theoretical relationship between job stress and WRMDs. These pathways highlight the physiological, psychological, and behavioral reactions to stress that can affect WRMDs directly and indirectly. One model stipulates that psychosocial work factors (e.g., work pressure, lack of control), which can cause stress, might also influence or be related to ergonomic factors such as force, repetition, and posture that have been identified as risk factors for WRMDs. In order to fully understand the etiology of WRMDs, it is important to examine both physical ergonomic and psychosocial work factors simultaneously. Smith and Carayon-Sainfort (1989) have proposed a model of the work system for stress management that provides a useful framework for conceptualizing the work-related factors that contribute to WRMDs. Practical applications of this research include practitioners taking into account psychosocial work factors and job stress in their efforts to reduce and control WRMDs. 相似文献