Intradermal and subcutaneous leiomyosarcoma: a clinicopathological and immunohistochemical study of 41 cases

Superficial leiomyosarcomas are rare tumours. The lesions confined to the dermis, contrary to those involving the subcutis, have been reported to carry a favourable prognosis. A retrospective study of 41 consecutive cases of surgically treated intradermal and subcutaneous leiomyosarcomas was undertaken in order to determine the prognostic factors that may influence the survival of these patients. Seven tumours were predominantly intradermal and 34 involved the subcutaneous tissue. Fifty-four percent of the tumours were located in the lower extremities. All cases stained positively for smooth muscle antigen and 66% for desmin. The tumours were classified with regard to tumour grade I (low grade, 3%), II (intermediate, 12%), IIIA (high grade, 46%) and IIIB (high grade, 39%). In all patients, follow-up information was available. Mean follow-up time was 5 years. The patients with intradermal tumours were all alive without signs of recurrence, whereas 14 of those with leiomyosarcomas involving the subcutis have died with pulmonary metastases. Our study confirms that "pure" intradermal leiomyosarcomas independent of tumour grade behave in a benign fashion, probably due to small tumour size. Tumour size > or = 5 cm, deep localization with fascia involvement, and high malignancy grade (IIIB) were found to deteriorate survival based on a univariate analysis. However, in a multivariate analysis only tumour size was found to be an independent prognostic factor.     

A synopsis on node compromise detection in wireless sensor networks using sequential analysis (Invited Review Article)

By exploiting the unattended nature of the wireless sensor networks, an attacker can physically capture and compromise sensor nodes and then launch a variety of attacks. He can additionally create many replicas of a few compromised nodes and spread these replicas over the network, thus launching further attacks with their help. In order to minimize the damage incurred by compromised and replicated nodes, it is very important to detect such malicious nodes as quickly as possible. In this review article, we synthesize our previous works on node compromise detection in sensor networks while providing the extended analysis in terms of performance comparison to the related work. More specifically, we use the methodology of the sequential analysis to detect static and mobile compromised nodes, as well as mobile replicated nodes in sensor networks. With the help of analytical and simulation results, we also demonstrate that our schemes provide robust and efficient node compromise detection capability.     

Some spectral response characteristics of ZnTe thin films

Zinc telluride thin films have been grown at room temperature and higher temperature substrates by thermal evaporation technique in a vacuum of 10^-6 torr. A main peak in the photocurrent is observed at 781 nm (1.58 eV) with two lower amplitude peaks on the lower wavelength side and one on higher wavelength side. The evaluated thermal activation energy is found to correspond well with the main spectral peak. From these studies it can be inferred that temperatures up to 453 K is still in the extrinsic conductivity region of the studied ZnTe thin films. The paper was presented at the 6th Asian Thermophysical Properties Conference (6th ATPC), held at Gauhati University, during 8–11 October 2001.     

Information-intensive wireless sensor networks: potential and challenges

Conventional wireless sensor networks rely mostly on simple scalar data (such as temperature or humidity) and specialize in single-purpose applications. Taking a fundamental departure, in this article we motivate information-rich wireless video sensor networks that emulate the compound eyes found in certain arthropods. Although constrained by scarce resources, sensor nodes can only serve extremely low-resolution video streams; the availability of vast amount of such streams due to deployment redundance can suffice for the need of information hungry applications. Unfortunately, the unique characteristics of wireless video sensor networks will introduce novel uncertainty-driven challenges in the information-intensive and yet resource-constrained environment. Correspondingly, we describe key research problems in the areas of networking, security, sensor design, and video-data analysis     

Erosion-corrosion behavior of SiC particle-reinforced Al-Si alloy in NaOH slurry

The erosion-corrsosion behavior of SiC particle-reinforced Al-Si alloy has been studied in NaOH slurry simulating the mining atmosphere. The study was performed at two different sand concentrations, namely, 20 and 30 wt pct, and at a speed of 900 rpm. It is depicted that the wear rates decreased with increasing sand content, indicating that corrosion is the dominating mode of material removal. Further composite exhibited lower wear resistance than the laloys irrespective of the sand concentration. Scanning electron microscope (SEM) observations indicated the dissolution of dendrites of Al due to severe corrosion, leaving behind the network of Si. This ultimately results in the falling of Si particles from the matrix, leaving behind voids. This also results in the formation of voids around the SiC particles and leads to pullout of SiC particles from the matrix during the wear process.     

Stress intensity factors for an interfacial crack between an orthotropic half-plane bonded to a dissimilar orthotropic layer with a punch

The plane strain problem of determining Stress Intensity Factors (SIF) for a moving interfacial Griffith crack between an elastic orthotropic half-plane and a dissimilar orthotropic layer with a moving punch situated along the boundary of the layer have been considered. The problem is reduced to the solution of three simultaneous singular integral equations with Cauchy-type singularities. Expressions for SIF for the case of a general loading are obtained. Numerical results for some particular cases are also presented graphically.     

A Novel Neurofilament Light Chain ELISA Validated in Patients with Alzheimer’s Disease,Frontotemporal Dementia,and Subjective Cognitive Decline,and the Evaluation of Candidate Proteins for Immunoassay Calibration

Neurofilament light chain (Nf-L) is a well-known biomarker for axonal damage; however, the corresponding circulating Nf-L analyte in cerebrospinal fluid (CSF) is poorly characterized. We therefore isolated new monoclonal antibodies against synthetic peptides, and these monoclonals were characterized for their specificity on brain-specific intermediate filament proteins. Two highly specific antibodies, ADx206 and ADx209, were analytically validated for CSF applications according to well-established criteria. Interestingly, using three different sources of purified Nf-L proteins, a significant impact on interpolated concentrations was observed. With a lower limit of analytical sensitivity of 100 pg/mL using bovine Nf-L as the calibrator, we were able to quantify the Nf-L analyte in each sample, and these Nf-L concentrations were highly correlated to the Uman diagnostics assay (Spearman rho = 0.97, p < 0.001). In the clinical diagnostic groups, the new Nf-L ELISA could discriminate patients with Alzheimer’s disease (AD, n = 20) from those with frontotemporal lobe dementia (FTD, n = 20) and control samples with subjective cognitive decline (SCD, n = 20). Henceforth, this novel Nf-L ELISA with well-defined specificity and epitopes can be used to enhance our understanding of harmonizing the use of Nf-L as a clinically relevant marker for neurodegeneration in CSF.     

Aluminum industry and climate change—Assessment and responses

It is now possible to assess the impact of the production processes of aluminum on the environment and to describe some of the ongoing responses and opportunities for improvement. This is compared with the benefits of aluminum in transportation, where the growing usage in various forms of transport due to its low density, high strength, and ability to be recycled enables reduced mass, increased fuel efficiency, reduced emissions and increased safety. It is the purpose of this paper to compare and contrast the emissions generated in the production of aluminum with the benefits accruing from its increased use in transportation.     

Design and Implementation of Optical Signal Reinstatement Technique for High DPSK RZ Transceiver Scheme

Wireless Personal Communications - Optical signal reinstatement (OSR) is a common technique used in high-speed communication systems. OSR can be achieved using various techniques such as;...