浇注型耐热聚氨酯树脂材料的合成及性能

以二异氰酸酯(4,4’-二苯甲烷二异氰酸酯MDI;4,4’-二环己基甲烷二异氰酸酯Hl2MDI),聚醚多元醇(PPG),小分子交联扩链剂,催化剂及助剂合成了一系列耐热聚氨酯树脂材料。用FT-IR表征了结构,用X射线衍射分析了微观结构,用DSC,TGA对其热稳定性进行了分析测试,对力学性能也进行了测试。结果表明,合成的聚氨酯材料具有高耐热性和卓越的力学性能。     

魅力型领导与团队学习:团队目标明确度的缓冲效应

本研究采用分组回归方法,以89支学生研究项目团队作为研究对象,考查魅力型领导与团队学习间的影响关系;并检验了团队目标的明确程度对魅力型领导和团队学习间关系所起的缓冲效应.结果表明,魅力型领导有助于团队学习;另一方面,当团队目标相对明确时,魅力型领导对团队学习的积极影响效应才较为显著;而当团队目标相对不明确时,魅力型领导...     

Comparative Analyses of Medicinal Chemistry and Cheminformatics Filters with Accessible Implementation in Konstanz Information Miner (KNIME)

High-throughput virtual screening (HTVS) is, in conjunction with rapid advances in computer hardware, becoming a staple in drug design research campaigns and cheminformatics. In this context, virtual compound library design becomes crucial as it generally constitutes the first step where quality filtered databases are essential for the efficient downstream research. Therefore, multiple filters for compound library design were devised and reported in the scientific literature. We collected the most common filters in medicinal chemistry (PAINS, REOS, Aggregators, van de Waterbeemd, Oprea, Fichert, Ghose, Mozzicconacci, Muegge, Egan, Murcko, Veber, Ro3, Ro4, and Ro5) to facilitate their open access use and compared them. Then, we implemented these filters in the open platform Konstanz Information Miner (KNIME) as a freely accessible and simple workflow compatible with small or large compound databases for the benefit of the readers and for the help in the early drug design steps.     

松软煤层中螺旋钻进技术应用

对松软煤层中螺旋钻进技术进行了介绍,并对其输煤原理及钻进工艺规程参数进行理论分析,利用此技术在新元煤矿松软煤层钻进成孔取得较好的效果。     

一种改进的Wu-Manber多关键字匹配算法

针对Wu-Manber算法在处理公共子后缀模式情况下的不足,该文提出了一种基于非空公共子后缀模式的处理算法。该算法把有非空公共子后缀的模式汇集在一起,进一步减小了next链表的平均长度。在匹配过程中减少了字符比较的次数,从而提高算法的运行效率。该文对搜狗实验室给出的相关文档进行全文检索实验,并和原Wu-Manber算法、孙晓山等提出的改进算法进行比较。实验结果表明,该文提出的改进算法有效地减少了匹配过程中字符比较的次数,从而提高匹配的速度和效率。     

冬青树叶表面的红外光谱特征

用红外衰减全反射技术(ATR)研究了各生长期和不同环境中冬青树叶表面的红外光谱特征.当用黑色塑料袋套在冬青枝条上48 h后,树叶表面的水分有所增加,其它成分变化甚微.当用透明塑料袋套在枝条上48 h后,树叶表面酯类物质的特征峰1 730、1 682 cm-1增加,且峰强度相当.当冬青叶片与甲苯气体接触48 h后,叶片反面酯类物质的特征峰(1 730、1 168、1 039 cm-1)有所减少.同样,叶片正面的酯类物质(1 730、1 168、1 039 cm-1)也有所减少.扫描电镜能谱也证实了叶片反面酯类物质确有减少.     

Strong Hydrogen Bonds in Acetylenedicarboxylic Acid Dihydrate

Acetylenedicarboxylic acid dihydrate (ADAD) represents a complex with strong hydrogen bonding between the carboxylic OH and the water molecule. An X-ray re-examination of the ADAD crystal structure confirms the O^…O distance of the short hydrogen bonds, and clearly shows different bond lengths between the two oxygen atoms with respect to the carbon atom in the carboxyl group, indicating a neutral structure for the complex. The neutral structure was also confirmed by vibrational spectroscopy, as no proton transfer was observed. The diffraction studies also revealed two polymorph modifications: room temperature (α) and low temperature (β), with a phase transition at approximately 4.9 °C. The calculated vibrational spectra are in satisfactory agreement with the experimental spectra. A comparison of the structure and the vibrational spectra between the ADAD and the oxalic acid dihydrate reveals some interesting details. The crystal structures of both crystal hydrates are almost identical; only the O^…O distances of the strongest hydrogen bonds differ by 0.08 Å. Although it was expected that a larger O^…O spacing in the ADAD crystal may significantly change the infrared and Raman spectra, especially for the frequency and the shape of the acidic OH stretching vibration, both the shape and frequency are almost identical, with all subpeaks topped on the broad OH stretching vibration. The O^…O distance dependent are only in- and out-of-plane OH deformations modes. The presence of polarons due to the ionized defects was not observed in the vibrational spectra of ADAD. Therefore, the origin of the broad OH band shape was explained in a similar way to the acid dimers. The anharmonicity of a potential enhances the coupling of the OH stretching with the low-frequency hydrogen bond stretching, which, in addition to the Fermi resonance, structures the band shape of the OH stretching. The fine structure found as a superposition of a broad OH stretching is attributed to Davydov coupling.     

Roles of Notch Signaling in the Tumor Microenvironment

The Notch signaling pathway is an architecturally simple signaling mechanism, well known for its role in cell fate regulation during organ development and in tissue homeostasis. In keeping with its importance for normal development, dysregulation of Notch signaling is increasingly associated with different types of tumors, and proteins in the Notch signaling pathway can act as oncogenes or tumor suppressors, depending on the cellular context and tumor type. In addition to a role as a driver of tumor initiation and progression in the tumor cells carrying oncogenic mutations, it is an emerging realization that Notch signaling also plays a role in non-mutated cells in the tumor microenvironment. In this review, we discuss how aberrant Notch signaling can affect three types of cells in the tumor stroma—cancer-associated fibroblasts, immune cells and vascular cells—and how this influences their interactions with the tumor cells. Insights into the roles of Notch in cells of the tumor environment and the impact on tumor-stroma interactions will lead to a deeper understanding of Notch signaling in cancer and inspire new strategies for Notch-based tumor therapy.     

新兴本科院校理工科学生词汇学习策略调查

对新兴本科院校理工科158名学生的词汇学习观念和策略使用情况的调查表明:新兴本科院校理工科学生普遍认为词汇学习很重要,赞成边用边学;但采用的策略少于其他名校和历史悠久的本科院校的学生;其中使用频率较高的策略只有选择性注意、查词典、猜测和自我激励策略;好生与差生的词汇学习观念和策略使用存在很大的差异。