MS Smotherman  PM Narins 《Canadian Metallurgical Quarterly》1998,79(1):312-321

There has been increasing interest in the interrelationship between systemic osteoporosis, oral bone loss, tooth loss, and risk factors for these conditions. Because the severity of alveolar bone loss increases with age, it has long been hypothesized that it may, in part, be related to systemic conditions that also predispose the patient to osteoporosis/osteopenia. The purpose of this paper is to review the risk factors for osteoporosis and periodontitis, as well as the evidence that loss of oral bone mineral may be related to systemic osteopenia. There is also evidence that therapies designed to influence systemic bone mineral density, such as hormone replacement and bisphosphonate therapy, may be associated with less tooth loss and a slower loss of alveolar bone, respectively.  相似文献   

    

TM Engber  SA Dennis  BE Jones  MS Miller  PC Contreras 《Canadian Metallurgical Quarterly》1998,87(4):905-911

Modafinil is a novel wake-promoting compound for which the mechanism and sites of action are unknown. We examined the neural substrates in the brain for the actions of modafinil using 2-deoxyglucose autoradiography and compared the findings to those obtained with amphetamine. Modafinil showed a relatively restricted pattern of changes in brain regional metabolic activity, while amphetamine altered glucose utilization in a wide variety of brain regions. Both modafinil and amphetamine increased glucose utilization in all subregions of the hippocampus (subiculum, CA1-CA3 and dentate gyrus) and in the centrolateral nucleus of the thalamus. Modafinil also increased glucose utilization in the central nucleus of the amygdala, but amphetamine had no effect in this region. Brain structures in which amphetamine increased metabolic rate but modafinil had no effect included regions of the basal ganglia, other nuclei of the thalamus, the frontal cortex, the nucleus accumbens, the ventral tegmental area and the pontine reticular fields. These findings suggest that, while both modafinil and amphetamine promote wakefulness, they act via distinctly different mechanisms. Modafinil appears to act on a specific subset of brain pathways which regulate sleep and wakefulness, whereas amphetamine affects a greater number of cerebral structures involved in the regulation of these behavioral states. Modafinil also lacks the pronounced effects on the extrapyramidal motor system which are characteristic of amphetamine and other psychomotor stimulants, implying that the effects of modafinil are not mediated by the dopamine system and that modafinil may selectively increase wakefulness with fewer side effects.  相似文献   

    

MS Dykewicz 《Canadian Metallurgical Quarterly》1996,22(6):353-359

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HH Wen  RL Wang  HC Li  B Yin  SQ Guo  ZX Zhao  SL Yan  L Fang  MS Si 《Canadian Metallurgical Quarterly》1996,54(2):1386-1390

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A Osland  D Beyene  HK Vefring  T Rinke De Wit  MS Wright 《Canadian Metallurgical Quarterly》1996,18(5):265-269

Recombinant DNA fragments from Leishmania aethiopica that code for epitopes which react with human antibodies have been characterized by cross-hybridization studies and DNA sequence analysis. Twenty clones could be grouped into seven different groups (I-VII), probably representing seven different L. aethiopica antigens. The DNA sequences of representative clones from the seven groups have been obtained and the amino acid sequence of the respective recombinant antigens established. The recombinant antigens have been analysed by epitope scanning with patient sera, and octapeptides that contain potential B-cell epitopes have been identified in all seven recombinant antigens. These octapeptides have further been tested with additional patient sera and control sera, and three octapeptides (HAFCHEEG, YHSSVVHD and SYAPCSLK) were found to contain major epitopes recognizing specific antibodies in nine, seven and four, respectively, of the twenty sera tested. Fifteen of the twenty sera reacted with one or more of these three octapeptides.  相似文献   

    

MS George  EM Wassermann  WA Williams  J Steppel  A Pascual-Leone  P Basser  M Hallett  RM Post 《Canadian Metallurgical Quarterly》1996,8(2):172-180

A person's reality and definition of self are socially constructed; ethnicity is integrally involved in this process. Clinical work is successful if the client constructs a self with a sense of positive self-esteem and empowerment. The profession views social workers' use of self as important in successful clinical work, especially with clients ethnically different from themselves. This article provides a framework adapted from a constructivist perspective for the clinician's skillful use of self in therapeutic discourse. The framework consists of five stances the clinician can use in transcending the discomfort he or she may experience in a cross-cultural clinical situation. Use of these stances facilitates clients' ethnic validation, which is essential to positive therapeutic outcomes. This article uses case examples to illustrate the use of the framework.  相似文献   

    

MS Seelig 《Canadian Metallurgical Quarterly》1993,12(4):442-458

The anticonvulsive and antihypertensive values of magnesium (Mg) in eclampsia, and its antiarrhythmic applications in a variety of cardiac diseases, have caused Mg to be considered only for parenteral administration by many physicians. In contrast, nutritionists have long recognized Mg as an essential nutrient, because severe deficiencies elicit neuromuscular manifestations similar to those justifying its use in eclampsia. More recently, this element has been used to favorably influence latent tetany with and without thrombotic complications, to delay preterm birth, to influence premenstrual syndrome, and to ameliorate migraine headaches. Most of these disorders exclusively or largely afflict women. The lesions of arteries and heart caused by experimental Mg deficiency have been well documented and may contribute to human cardiovascular disease. Estrogen's enhancement of Mg utilization and uptake by soft tissues and bone may explain resistance of young women to heart disease and osteoporosis, as well as increased prevalence of these diseases when estrogen secretion ceases. However, estrogen-induced shifts of Mg can be deleterious when estrogen levels are high and Mg intake is suboptimal. The resultant lowering of blood Mg can increase the Ca/Mg ratio, thus favoring coagulation. With Ca supplementation in the face of commonly low Mg intake, risk of thrombosis increases.  相似文献   

    

A.&#x;M. Adawi  A. Cadby  L.&#x;G. Connolly  W.‐C. Hung  R. Dean  A. Tahraoui  A.&#x;M. Fox  A.&#x;G. Cullis  D. Sanvitto  M.&#x;S. Skolnick  D.&#x;G. Lidzey 《Advanced materials (Deerfield Beach, Fla.)》2006,18(6):742-747

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Acute anabolic response to β-hydroxy-β-methylbutyrate (HMB)-free acid supplementation following heavy resistance exercise     

JR Townsend  JR Stout  JR Hoffman  AM Gonzalez  AR Jajtner  AJ Wells  CH Boone  KS Beyer  GT Mangine  EH Robinson  GJ Pruna  JD Bohner  MS Fragala  DH Fukuda 《Journal of the International Society of Sports Nutrition》2014,11(Z1):P16

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Anomalous values of interaction constants in the two-dimensional electron gas of a silicon metal-oxide-semiconductor field-effect transistor measured by parallel- and perpendicular-field magnetoconductivity     

MS Burdis  CC Dean 《Canadian Metallurgical Quarterly》1988,38(5):3269-3275

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