加拿大特累尔铅锌冶炼厂的现代化扩建

加拿大科明科公司花费7.0亿美元使特累尔铅锌熔炼与精炼厂进行了现代化扩建。从采用先进的披术和先进的工业卫生观点来看,这将保证该厂作为世界上重要有色冶金联合企业之一的地位。由于生产不能中断,要求设计、建设与生产人员之间紧密合作,故该厂扩建工程所遇到的困难比建设一个新的联合企业更多。     

Extracellular and intracellular volume variations during postural change measured by segmental and wrist-ankle bioimpedance spectroscopy

Extracellular (ECW) and intracellular (ICW) volumes were measured using both segmental and wrist-ankle (W-A) bioimpedance spectroscopy (5-1000 kHz) in 15 healthy subjects (7 men, 8 women). In the 1st protocol, the subject, after sitting for 30 min, laid supine for at least 30 min. In the second protocol, the subject, who had been supine for 1 hr, sat up in bed for 10 min and returned to supine position for another hour. Segmental ECW and ICW resistances of legs, arms and trunk were measured by placing four voltage electrodes on wrist, shoulder, top of thigh and ankle and using Hanai's conductivity theory. W-A resistances were found to be very close to the sum of segmental resistances. When switching from sitting to supine (protocol 1), the mean ECW leg resistance increased by 18.2%, that of arm and W-A by 12.4%. Trunk resistance also increased but not significantly by 4.8%. Corresponding increases in ICW resistance were smaller for legs (3.7%) and arm (-0.7%) but larger for the trunk (21.4%). Total body ECW volumes from segmental measurements were in good agreement with W-A and Watson anthropomorphic correlation. The decrease in total ECW volume (when supine) calculated from segmental resistances was at 0.79 l less than the W-A one (1.12 l). Total ICW volume reductions were 3.4% (segmental) and 3.8% (W-A). Tests of protocol 2 confirmed that resistance and fluid volume values were not affected by a temporary position change.     

Identification of nasopharyngeal carcinoma antigens that induce humoral immune response by proteomic analysis

A proteomics-based approach has been used to identify proteins that commonly elicit a humoral immune response in nasopharyngeal carcinoma (NPC). Sera from 19 newly diagnosed NPC patients and 19 healthy individuals were analyzed for IgG autoantibodies against NPC proteins resolved by 2-DE. Protein spots that exhibited selective reactivity with sera from NPC patients were identified by MS. Among nine identified proteins, cytokeratin 19 (CK19), Erb3 binding protein (EBP1), and Rho GDP dissociation inhibitor-beta (Rho-GDI-2) induced autoantibodies in more than 36.8% of NPC patients but not in healthy individuals. Furthermore, Western blot analysis and immunohistochemical staining were performed to determine the expression and localization of CK19, EBP1, and Rho-GDI-2 in NPC and normal nasopharyngeal mucosal tissues. Up-regulated CK19 and EBP1, but not Rho-GDI-2, were observed in NPC vs. normal tissue. Subcellular localization of the three proteins in NPC tissue was same as that in the normal tissue. Thus, overexpression of CK19 and EBP1 may be one of the mechanisms for their autoantibody development in NPC. To validate the findings of a proteomic analysis, occurrence of autoantibodies against these three proteins was detected by immunoprecipitation and Western blot analysis in additional 30 NPC patients, 23 other types of cancer patients and 20 healthy individuals. Results showed that frequency of autoantibodies against CK19, EBP1 and Rho-GDI-2 in NPC patients was significantly higher than that in other types of cancer patients and healthy individuals. We conclude that CK19, EBP1 and Rho-GDI-2 may have utility in NPC screening and diagnosis.     

Conditional mutual information-based feature selection for congestive heart failure recognition using heart rate variability

Feature selection plays an important role in pattern recognition systems. In this study, we explored the problem of selecting effective heart rate variability (HRV) features for recognizing congestive heart failure (CHF) based on mutual information (MI). The MI-based greedy feature selection approach proposed by Battiti was adopted in the study. The mutual information conditioned by the first-selected feature was used as a criterion for feature selection. The uniform distribution assumption was used to reduce the computational load. And, a logarithmic exponent weighting was added to model the relative importance of the MI with respect to the number of the already-selected features. The CHF recognition system contained a feature extractor that generated four categories, totally 50, features from the input HRV sequences. The proposed feature selector, termed UCMIFS, proceeded to select the most effective features for the succeeding support vector machine (SVM) classifier. Prior to feature selection, the 50 features produced a high accuracy of 96.38%, which confirmed the representativeness of the original feature set. The performance of the UCMIFS selector was demonstrated to be superior to the other MI-based feature selectors including MIFS-U, CMIFS, and mRMR. When compared to the other outstanding selectors published in the literature, the proposed UCMIFS outperformed them with as high as 97.59% accuracy in recognizing CHF using only 15 features. The results demonstrated the advantage of using the recruited features in characterizing HRV sequences for CHF recognition. The UCMIFS selector further improved the efficiency of the recognition system with substantially lowered feature dimensions and elevated recognition rate.     

氧气喷撒熔炼

美国菲尔普斯·道奇公司的莫伦西炼铜厂采用氧气喷撒熔炼技术改造了一台反射炉,于1982年10月14日正式加料投入生产。氧气喷撒熔炼技术是将氧气和炉料加入氧气喷撒燃烧器,使精矿在炉膛空间形成的断面呈抛物面形的火焰中燃烧,进行熔炼作业。如需补充燃料,可将粉煤混入精矿中和精矿一道加入炉内。为了充分利用氧焰的过剩热量,并保护炉衬,在炉子两侧墙仍然进行加料,可熔     

Mitochondria: A mirror into cellular dysfunction in heart disease

Cardiovascular (CV) disease is the single most significant cause of morbidity and mortality worldwide. The emerging global impact of CV disease means that the goals of early diagnosis and a wider range of treatment options are now increasingly pertinent. As such, there is a greater need to understand the molecular mechanisms involved and potential targets for intervention. Mitochondrial function is important for physiological maintenance of the cell, and when this function is altered, the cell can begin to suffer. Given the broad range and significant impacts of the cellular processes regulated by the mitochondria, it becomes important to understand the roles of the proteins associated with this organelle. Proteomic investigations of the mitochondria are hampered by the intrinsic properties of the organelle, including hydrophobic mitochondrial membranes; high proportion of basic proteins (pI greater than 8.0); and the relative dynamic range issues of the mitochondria. For these reasons, many proteomic studies investigate the mitochondria as a discrete subproteome. Once this has been achieved, the alterations that result in functional changes with CV disease can be observed. Those alterations that lead to changes in mitochondrial function, signaling and morphology, which have significant implications for the cardiomyocyte in the development of CV disease, are discussed.     

芳烃抽提开工总结

本文简述了九江石化总厂芳烃抽提装置开工的过程，并对开工过程中的一些现象作了技术上的分析总结。文中介绍了用风动隔膜泵装溶剂的方法。     

铜

与多年来铜的消费下降而产量上升形成尖锐的对比,1988年铜的消费连续三年保持着明显的良好状况,然而生产厂家却经受了总产量大为减少的一系列灾难。今年许多国家发生了     

油脂加工过程对大豆油中微量化合物含量及豆油氧化稳定性的影响

毛豆油经过脱胶、碱炼、脱色、脱臭的加工过程,能除去99.8％的磷脂、90.7％的铁、100％的叶绿素,97.3％的游离脂肪酸和31.8％的生育酚。加工过程中豆油磷和铁的含量变化相关系数为r=0.99;在毛油、脱胶油、碱炼油、脱色油和脱臭油中α-、β-、γ-和δ-生育酚的相对比例几乎是恒定不变的。在豆油中γ-和δ-生育酚占豆油中生育酚总量的94％。豆油的氧化稳定性顺序为:毛油>脱臭油>脱胶油>碱炼油>脱色油。