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21.
Slab milling with a conical shaped milling tool and slab milling with a face milling tool are wood machining techniques which meet the current requirements of wood machining and processing (e.g. changing batch sizes, flexible machines and equipment). That is why the Institute for Machine Tools at University of Stuttgart has already conducted comprehensive basic research in this field (Heisel 1997). Research on slab milling with a face milling tool was especially promoted as an alternative to slab milling with a peripheral milling tool (also known as planing) due to its low noise emission and low energy consumption. Amongst others, slab milling with a face milling tool as pre-milling procedure when calibrating wood-based panel products was examined under technical and economic aspects. The results showed higher service life and continuously better surfaces when choosing the right geometry of the cutting tools as compared to conventional slab milling with a peripheral milling tool. Notwithstanding the high costs, diamond cutting edges are more cost-effective than carbide insert tips due to their longer service life (Heisel 2004).  相似文献   
22.
In this paper we describe how behavioral responses of carbon dioxide (CO2) tax increases are accounted for in tax revenue estimation in Sweden. The rationale for developing a method for this is a mix between that a CO2 tax is a primary climate policy tool aiming to reduce CO2 emissions and that the CO2 tax generates sizable tax revenues.  相似文献   
23.
The present work presents a method to encapsulate pre-synthesised Ru nanoparticles (NPs) by Pt using a polyol method without capping agents at various pH values (6, 7, 8 and 10). The structural and surface properties of the catalysts were characterised using X-ray diffraction, transmission electron microscopy, CO stripping, and energy-dispersive X-ray spectroscopy. The studies suggest that the pH during encapsulation of Ru by Pt plays an important role in controlling of shell composition. A core–shell catalyst with an alloy shell was obtained at a pH of 6, whereas a monometallic Pt shell was obtained at a pH of 10. The core–shell catalysts gave higher steady-state current for methanol oxidation: 10-fold higher for alloy shells and 5-fold higher for Pt-enriched shells compared to the pure Pt catalyst. It is suggested that the highest catalytic enhancement of the core–shell catalysts is obtained through the bi-functional character that dominates the alloy shells rather than the ligand-effect-promoted Pt-enriched shells.  相似文献   
24.
A stochastic finite element-based approach for forming limit calculations of sheets is proposed and evaluated. Material inhomogeneities are represented by spatial thickness variations of the sheet which are modelled by the use of random fields. The effects of changing the smoothness, wavelengths, amplitude and anisotropy of the field realisations on the forming limit diagram are investigated. Further, the effects of the patch size and plastic anisotropy on the forming limit diagram are studied. The assumed thickness variations result in a quite wide scatter band, and changes of the characteristics of the thickness field result in changes of the shape and variance of the forming limit diagram.  相似文献   
25.
We studied the coupled impurity states in a freestanding semiconductor nanowire (NW), within the effective mass approximation and including the effect of the dielectric mismatch, by using finite element method. Bonding and anti-bonding states are found and their energies converge with increasing distance di between the two impurities. The dependence of the binding energy on the wire radius R and the distance di between the two impurities is investigated, and we compare it with the result of a freestanding NW that contains a single impurity.  相似文献   
26.
This paper reports on the use of qualitative analysis to inform a risk analysis framework for decentralised water systems. To realise the benefits from these technologies, a methodology is applied to learn from previous difficulties in implementing and managing them. A workshop process was used to capture stories from industry professionals on difficulties they have encountered in planning and implementation. Qualitative analysis of story narratives revealed stages where there was some type of development process failure; as well as failure modes and factors influencing the difficulties encountered. The analysis also generated insights: difficulties in one part of the development process tends to propagate to subsequent stages; system difficulties most often occurred in the policy stage of development due to institutional inertia and lack of adaptive governance; and the best indicator of problems with a decentralised system was complaints of poor water quality. Furthermore, this paper also provides a method to learn from past difficulties by identifying what data needs to be collected in order to populate a risk model which can be used for improving risk assessment of the development process for decentralised systems. This can provide a basis for better decision making, policy and guidelines; an important factor in mainstream acceptance.  相似文献   
27.
    
A series of glycolated polythiophenes for use in organic electrochemical transistors (OECTs) is designed and synthesized, differing in the distribution of their ethylene glycol chains that are tethered to the conjugated backbone. While side chain redistribution does not have a significant impact on the optoelectronic properties of the polymers, this molecular engineering strategy strongly impacts the water uptake achieved in the polymers. By careful optimization of the water uptake in the polymer films, OECTs with unprecedented steady-state performances in terms of [μC*] and current retentions up to 98% over 700 electrochemical switching cycles are developed.  相似文献   
28.
The inclusion of wind power into power systems has a significant impact on the demand for real-time balancing power due to the stochastic nature of wind power production. The overall aim of this paper is to present probabilistic models of the impact of large-scale integration of wind power on the continuous demand in MW for real-time balancing power. This is important not only for system operators, but also for producers and consumers since they in most systems through various market solutions provide balancing power.  相似文献   
29.
    
Vascular endothelial cells express glycoprotein 130 (gp130), which is utilized as a signaling receptor by cytokines in the interleukin-6 (IL-6) family. Several IL-6 family cytokines can be found in the circulatory system during physiological or pathological conditions, and may influence endothelial function and response. This study evaluated and compared the cellular and molecular responses induced by IL-6 family cytokines in human endothelial cells. A proteomic analysis showed that IL-6 family cytokines induce the release of a range of proteins from endothelial cells, such as C-C motif chemokine ligand 23, hepatocyte growth factor, and IL-6. Pathway analysis indicated that gp130-signaling in endothelial cells regulates several functions related to angiogenesis and immune cell recruitment. The present investigation also disclosed differences and similarities between different IL-6 family cytokines in their ability to induce protein release and regulate gene expression and intracellular signaling, in regards to which oncostatin M showed the most pronounced effect. Further, this study showed that soluble gp130 preferentially blocks trans-signaling-induced responses, but does not affect responses induced by classic signaling. In conclusion, IL-6 family cytokines induce both specific and overlapping molecular responses in endothelial cells, and regulate genes and proteins involved in angiogenesis and immune cell recruitment.  相似文献   
30.
    
This study aimed to characterize different natural killer (NK) cell phenotypes on bone marrow and peripheral blood cells from acute myeloid leukemia (AML) patients and healthy donors (HDs). Our data show that CD56dimCD16 and CD56brightCD16 NK cells represent the predominant NK cell subpopulations in AML, while the CD56dimCD16+ NK cells are significantly reduced compared to HDs. Moreover, TIGIT+ and PVRIG+ cells cluster on the CD56dimCD16+ subset whereas CD39+ and CD38+ cells do so on CD56brightCD16 NK cells in AML. Furthermore, functional effects of (co-)blockade of TIGIT and CD39 or A2AR on NK cell functionality were analyzed. These experiments revealed that the single blockade of the TIGIT receptor results in an increased NK-92 cell-mediated killing of AML cells in vitro. Combined targeting of CD39 or A2AR significantly augments the anti-TIGIT-mediated lysis of AML cells. Our data indicate that distinct NK cell subsets in AML exhibit different immunosuppressive patterns (via the TIGIT/PVRIG receptors and the purinergic pathway). In summary, we conclude that TIGIT, CD39, and A2AR constitute relevant inhibitory checkpoints of NK cells in AML patients. A combinatorial blockade synergistically strengthens NK-92 cell-mediated cytotoxicity. As inhibitors of TIGIT, CD39, and A2AR are clinically available, studies on their combined use could be conducted in the near future.  相似文献   
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