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31.
Chronic Myeloid Leukemia (CML) is a clonal disease of bone marrow, citogenetically characterized by the presence of the Philadelphia chromosome (Ph). Additional anomalies in the Ph cromosome have been found during the evolution of CML. This paper will show evidence of cytogenetic abnormalities during the evolution of CML in this region, and its correlation with clinical evolution. 55 samples of bone marrow, 81.3% (45/55) in chronic phase (CP), 12.7% (7/55) in an accelerated phase (AP), and 5.4% (3/55) in blastic phase (BP) were received. In 12/45 patients in CP the karyotype was repeated at least once a year during the evolution of their illness. 9/12 presented the Ph chromosome as a single anomaly at the moment of diagnosis; the other 3 presented a distinct anomaly. 4/9 presented additional abnormalities moving to the stages AP or BP between 4-8 months after initial discovery. 7/10 patients referred in AP or BP presented additional abnormalities in the Ph chromosome. It is evident that the chromosome study of each patient with CML must be carried out at least once a year in order to detect chromosomal abnormalities in addition to the Ph chromosome. Thus, a greater therapeutic control of the disease is possible.  相似文献   
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The effects of chemical crosslinking on low density polyethylene are investigated, using electron microscopy, X-ray diffraction, n.m.r., and gel fraction determination. The results of these studies are discussed in terms of the degree of crosslinking estimated on the basis of peroxide content.  相似文献   
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Zusammenfassung Ein einfacher, in geschlossener Form lösbarer Fall wird behandelt, mit dem versucht werden soll, einen Beitrag zur Frage der Entlastungskerben zu liefern.
Summary As a contribution to the problem of stress relieve by notches a simple case is treated and solved in closed form.


Mit 4 Textabbildungen  相似文献   
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Despite all prophecies of its end, silicon-based microelectronics still follows Moore's Law and continues to develop rapidly. However, the inherent physical limits will eventually be reached. Carbon nanotubes offer the potential for further miniaturization as long as it is possible to selectively deposit them with defined properties.  相似文献   
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The rapid increase of renewable energy sources made coordinated control of the distributed and intermittent generation units a more demanded task. Matching demand and supply is particularly challenging in islanded microgrids. In this study, we have demonstrated a mixed‐integer quadratic programming (MIQP) method to achieve efficient use of sources within an islanded microgrid. A unique objective function involving fuel consumption of diesel generator, degradation in a lithium‐ion battery energy storage system, carbon emissions, load shifting, and curtailment of the renewable sources is constructed, and an optimal operating point is pursued using the MIQP approach. A systematic and extensive methodology for building the objective function is given in a sequential and explicit manner with an emphasis on a novel model‐based battery aging formulation. Performance of the designed system and a sensitivity analysis of resulting battery dispatch, diesel generator usage, and storage aging against a range of optimization parameters are presented by considering real‐world specifications of the Semakau Island, an island in the vicinity of Singapore.  相似文献   
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Solution‐processed, low cost thin films of layered semiconductors such as transition metal dichalcogenides (TMDs) are potential candidates for future printed electronics. Here, n‐type electrolyte‐gated transistors (EGTs) based on porous WS2 nanosheet networks as the semiconductor are demonstrated. The WS2 nanosheets are liquid phase exfoliated to form aqueous/surfactant stabilized inks, and deposited at low temperatures (T < 120 °C) in ambient atmosphere by airbrushing. No solvent exchange, further additives, or complicated processing steps are required. While the EGTs are primarily n‐type (electron accumulation), some hole transport is also observable. The EGTs show current modulations > 104 with low hysteresis, channel width‐normalized on‐conductances of up to 0.27 µS µm?1 and estimated electron mobilities around 0.01 cm2 V?1 s?1. In addition, the WS2 nanosheet networks exhibit relatively high volumetric capacitance values of 30 F cm?3. Charge transport within the network depends significantly on the applied lateral electric field and is thermally activated, which supports the notion that hopping between nanosheets is a major limiting factor for these networks and their future application.  相似文献   
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