A participatory process for the design of housing for a First Nations Community

First Nation (Indigenous) on-reserve housing in Canada is in crisis due to severe shortages, high reported instances of mould contamination, overcrowding and structural deficiencies. The Kitamaat reserve of the Haisla First Nation provides one example. The intent of the study reported here was to engage with the Haisla to develop a culturally appropriate, environmentally responsive and energy-efficient housing type that the Haisla could implement in the future. This work was undertaken by Marceau-Evans-Johnson Architects in collaboration with researchers at the University of Victoria. In this article, the circumstances leading to the present housing crisis are reviewed, the consultative design process with the Haisla and its outcomes are described, and the concept design solution which was co-developed for future housing is presented.     

Sorption of selenium oxyanions on TiO2 (rutile) studied by batch or column experiments and spectroscopic methods

Selenium is a known toxic element released in the environment by anthropogenic activities. The present study is devoted to the aqueous sorption behaviour of selenium oxyanions (selenate and selenite) on a reference oxide surface, namely rutile TiO(2). Batch sorption kinetics and isotherms have been studied using different physico-chemical conditions of the solution (changes of pH and ionic strength). The sorption was favoured for both anions in acidic conditions, in agreement with a surface complexation mechanism and CD-MUSIC predictions. Spectroscopic investigations of the sorbed rutile powder were also consistent with such a mechanism. EXAFS spectra confirmed that for selenite anions, an inner-sphere mechanism was the most probable process observed. Dynamic sorption experiments using a column filled with rutile powder also substantiated that a part of the surface complexes follows the inner-sphere mechanism, but also evidenced that an outer-sphere mechanism cannot be excluded, especially for selenate anions.     

A temporal revision model for reasoning about world change

Revision can be seen as any operation which turns a cognitive state CSt into a subsequent cognitive state CSt'. Two kinds of change can be considered: in the “belief change” case, the cognitive states represent beliefs on a world; they are revised in response to the getting of new information about a static world. In the “world change” case, the cognitive states represent known facts on a real world; they are revised in response to change in this dynamic world. We focus in the following on world change case and propose a way to keep up to date with a dynamic world. Reasoning about change requires predicting how the world will change along time. In absence of a predictive model of evolution, the commonsense law of inertia has been currently used and justifies the minimal change approach to the frame problem. We propose here to use an explicit transition model, which will be used as a predictive evolution model. Dean and Kanazawa propose to use a probabilistic model of persistence and causation. We propose in this paper to use a symbolic model of transition by directly encoding expectations. In the first two sections, we describe the formalism that we propose to explicitly encode the transition model and its axiomatisation. We give then a formal definition of the revision operation using a transition model and discuss what can be a contraction operation in the context of world change. an illustrative example is presented and in the last section, our approach is compared to other related works. © 1994 John Wiley & Sons, Inc.     

Repeated point contact loading on Ce-TZP

The deformation and fragmentation behaviour in a toughened ceria-stabilized zirconia ceramic have been investigated by using unlubricated repeated metallic point contact loading at room temperature to explore the possibilities of cyclic fatigue effects. All tests were conducted on a purpose-designed and built computer-controlled apparatus. 120° hardened silver steel cones were cyclically loaded on the polished Ce-TZP substrate, and the damage was observed and analysed as a function of the number of cycles for loads of 19.6 ± 9.8 N. The ground tips of the cones plastically deformed during the initial loading cycle to produce a flattened end which conformed with the substrate. A tetragonal → monoclinic martensitic transformation occurred in the zirconia beneath, and adjacent to, the contact zone. This transformation zone increased in size as the number of cycles increased, even though there was virtually no change in the diameter of the flattened tip. The expansion associated with this phase change in the zirconia caused granular lifting from the surface, at the edge of the contact zone, that resulted in intergranular fragmentation and spelling of the substrate. The hardness of the substrate in the contact zone increased by approximately 15% after 2×10⁵ cycles. Traces of metal transfer onto the ceramic substrate could be observed only at 2×10⁵ cycles and above.     

Selection of an adsorbent for lead removal from drinking water by a point-of-use treatment device

The removal of lead from drinking water was investigated to develop a point-of-use water filter that could meet the regulation imposed by the new European Directive 98-83 lowering lead concentration in drinking water below 10 μg L⁻¹. The objective of this research was to assess the potential of different adsorbents (zeolites, resins, activated carbon, manganese oxides, cellulose powder) to remove lead from tap water with a very short contact time. To begin, the repartition of the lead species in a tap water and a mineral water was computed with the computer model CHESS. It showed that in bicarbonated waters lead is mainly under lead carbonate form, either in the aqueous or in the mineral phase. Batch experiments were then conducted to measure the equilibrium adsorption isotherms of the adsorbents. Then, for five of them, dynamic experiments in micro-columns were carried out to assess the outlet lead concentration level. Three adsorbents gave rise to a leakage concentration lower than 10 μg L⁻¹ and were then selected for prototypes experiments: chabasite, an activated carbon coated with a synthetic zeolite and a natural manganese oxide. The proposed method clearly showed that the measurement of equilibrium isotherms is not sufficient to predict the effectiveness of an adsorbent, and must be coupled with dynamic experiments.     

Cancer stem cell sorting from colorectal cancer cell lines by sedimentation field flow fractionation

Recently, cancer stem cells (CSCs) have been identified in many types of cancers, such as colorectal cancer (CRC). CSCs seem to be involved in initiation, growth, and tumor metastasis, as well as in radio- and chemotherapy failures. CSCs appears as new biological targets for cancer therapy, requiring the development of noninvasive cell sorting methods. In this study, we used sedimentation field flow fractionation (SdFFF) to prepare enriched populations of CSCs from eight cell lines corresponding to different CRC grades. On the basis of phenotypic and functional characterizations, "hyperlayer" elution resulted in a fraction overexpressing CSC markers (CD44, CD166, EpCAM) for all cell lines. CSCs were eluted in the last fraction for seven out of eight cell lines, but in the first for HCT116. These results suggest, according to the literature, that two different pools of CSCs exist, quiescent and activated, which can both be sorted by SdFFF. Moreover, according to CSC properties, enriched fractions are able to form colonies.     

Synthesis and rheological study of some maleic acid and fumaric acid stereoregular polyesters

Summary First unsaturated polyester fibers were prepared starting from stereoregular, macromolecular poly(octamethylene fumarate). Fibers obtained from octamethylene copolyesters of fumaric and terephthalic acids manifested improved mechanical properties and higher melting points. All unsaturated polyester fibers prepared in the study, based on the homopolymer and on copolymers of fumaric acid, even those containing as low as 10% of fumaric acid residues, are able to be covalently bonded to an unsaturated polyester matrix.For part 7, see Jaovi M.S., et al., Makromol. Chem. (submitted)     

Does fusion of domains from unrelated proteins affect their folding pathways and the structural changes involved in their function? A case study with the diphtheria toxin T domain

We investigated whether the structural and functional behaviorsof two unrelated protein domains were modified when fused. TheIgG-binding protein ZZ derived from staphylococcal protein Awas fused to the N- and/or C-terminus of the diphtheria toxintransmembrane domain (T). T undergoes a conformational changefrom a soluble native state at neutral pH to a molten globule-likestate at acidic pH, leading to its interaction with membranes.We found that this molten globule state was not connected tothe GdnHCl-induced unfolding pathway of T. The pH-induced transitionof T, and also the unfolding of T and ZZ at neutral and acidicpH, were unchanged whether the domains were isolated or fused.The position of ZZ, however, influenced the solubility of Tnear its pK_i. SPR measurements revealed that T has a high affinityfor membranes, isolated or within the fusion proteins (K_D<10^-11 M). This work shows that in the case of T and ZZ, thefusion of protein domains with different stabilities does notalter the structural changes involved in folding and function.This supports the use of T as a soluble membrane anchor.     

Interactive building and augmentation of piecewise planar environments using the intersection lines

This paper describes a method for online interactive building of piecewise planar environments for immediate use in augmented reality. This system combines user interaction from a camera–mouse and automated tracking/reconstruction methods to recover planar structures of the scene that are relevant for the augmentation task. An important contribution of our algorithm is that the process of tracking and reconstructing planar structures is decomposed into three steps—tracking, computation of the intersection lines of the planes, reconstruction—that can each be visually assessed by the user, making the interactive modeling procedure really robust and accurate with intuitive interaction. Videos illustrating our system both on synthetic and long real-size experiments are available at .     

A decision-oriented model to evaluate the effect of land use and agricultural management on herbicide contamination in stream water

Modelling stream water pollution by herbicides in agricultural areas is a critical issue since numerous and incompletely known processes are involved. A decision-oriented model, SACADEAU-Transf, which represents water and pesticide transfer in medium-sized catchments (10–50 km²) is presented. This model aims at evaluating the effect of land use, agricultural practice and landscape on the contamination of stream water in rural catchments. The processes are represented in an easily understandable way with a moderate amount of information, producing semi-quantitative and spatialized outputs. Modelling focuses on the first few months after herbicide application when high levels of contamination are generally observed, by considering transfer through the catchment area via surface and subsurface flow. The surface flow, based on a tree plot network representation of the catchment, is controlled by soil-surface properties and saturated conditions. The subsurface flow based on Topmodel concepts is controlled by the topography. Herbicide transfer is coupled to water transfer by taking into account the main characteristics of the chemicals. The model simulates the daily water and herbicide outflow at the outlets of the farmers' fields as well as from the catchment. Preliminary results on maize herbicide transfer are presented for an agricultural catchment with an area of 17 km² located in north-western France. The relevance of SACADEAU-Transf model is discussed in view of the qualities required for the decision-oriented models developed for improving agro-environmental management.