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排序方式: 共有268条查询结果,搜索用时 15 毫秒
21.
Ian Marsden 《Urban Policy and Research》2013,31(2):70-77
Urban conservation controls, whereby a permit is required for any demolition, use or development in affected areas, were introduced into the Melbourne Metropolitan Planning Scheme in April 1984. This paper explores a number of key appeal decisions. It analyzes the relevant planning scheme objectives, the statutory framework, and a number of cases dealing with visual amenity, design solutions and architectural conformity. Some comparisons are then made with the application of similar controls both interstate and overseas. 相似文献
22.
ML Smith XY Hua DL Marsden D Liu NG Kennaway KY Ngo RH Haas 《Canadian Metallurgical Quarterly》1997,82(9):2826-2831
A 6-yr-old boy presented with muscle weakness, lactic acidemia, and insulin-dependent diabetes mellitus (IDDM). Using PCR and restriction enzyme analysis, he was found to have the classical A3248G mitochondrial DNA (mtDNA) mutation frequently associated with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). The mutation was confirmed by sequencing muscle mtDNA. The mutation in mtDNA from muscle, lymphoblasts, and blood was clearly demonstrable by standard methods using ethidium bromide staining. His mother also had IDDM, but no A3243G mutation could be detected in her blood or transformed lymphoblasts using the same PCR technique. When PCR was carried out in the presence of [32P]deoxycytidine triphosphate, subsequent autoradiography detected the presence of the mutation at low levels in mtDNA from the mother's lymphoblasts and blood. Study of the mother's muscle showed a mitochondrial myopathy, despite the fact that she was asymptomatic. We emphasize that the increased sensitivity of radiolabeled PCR may be necessary to detect small percentages of heteroplasmic A3243G mtDNA mutation in blood from diabetic subjects. Otherwise the incidence of mtDNA mutations in both IDDM and non-insulin dependent diabetes may be underestimated. 相似文献
23.
JP Spencer P Jenner SE Daniel AJ Lees DC Marsden B Halliwell 《Canadian Metallurgical Quarterly》1998,71(5):2112-2122
Oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine (DA) to generate semiquinones/quinones, oxygen radicals, and other reactive oxygen species may play a role in neuronal cell death in Parkinson's disease (PD). In particular, semiquinones/quinones can form conjugates with thiol compounds such as GSH and cysteine. Exposure of L-DOPA, DA, and other catecholamines to a system generating O2.- radical led to O2(.-)-dependent depletion of added GSH (or cysteine), accompanied by the formation of thiol-DA or -DOPA adducts as detected by HPLC. Superoxide could additionally cause destruction of these adducts. Iron or copper ions could also promote conjugate formation between GSH or cysteine and DA and L-DOPA, especially if H2O2 was present. We applied HPLC to measure glutathionyl and cysteinyl conjugates of L-DOPA, DA, and 3,4-dihydroxyphenylacetic acid (DOPAC) in postmortem brain samples from PD patients and normal control subjects. Conjugates were detected in most brain areas examined, but levels were highest in the substantia nigra and putamen. In most regions, adduct levels were lower in PD, but there were significant increases in cysteinyl adducts of L-DOPA, DA, and DOPAC in PD substantia nigra, suggesting that acceleration of L-DOPA/DA oxidation occurs in PD, although we cannot say if this is a primary feature of the disease or if it is related to therapy with L-DOPA. In vitro, conjugate formation could be inhibited by the dithiol dihydrolipoate but not by its oxidised form, lipoic acid. 相似文献
24.
The effect of the threshold stress on the determination of the Weibull parameters in probabilistic failure analysis 总被引:1,自引:0,他引:1
J. Smart B. C. Mitchell S. L. Fok B. J. Marsden 《Engineering Fracture Mechanics》2003,70(18):2559-2567
In the analysis of brittle materials and components the probability of failure is commonly modelled using a two-parameter Weibull distribution. Occasionally, a three-parameter model is used when the material shows significant threshold behaviour. In this paper two methods for determining the three-parameter constants are discussed. Two theoretical two- and three-parameter distributions are then analysed to examine the number of samples needed to determine the parameters accurately. The two-parameter models are the best fits of the three-parameter models and their failure distributions are very similar to the three-parameter distributions. It is concluded that far more specimens need to be tested than is usually the case to be confident that the correct distribution has been found. 相似文献
25.
M Nakane JS Pollock V Klinghofer F Basha PA Marsden A Hokari T Ogura H Esumi GW Carter 《Canadian Metallurgical Quarterly》1995,206(2):511-517
Complementary DNAs encoding three human isoforms (neuronal, inducible, and endothelial) of nitric oxide synthase were cloned into the baculovirus expression vector pVL1392/1393. Transfection of Sf-9 insect cells with the recombinant baculovirus resulted in the expression of high levels of nitric oxide synthases. The expressed proteins of neuronal and inducible nitric oxide synthase were predominantly soluble, whereas the endothelial enzyme was for the most part, particulate. Recombinant enzymes were purified with 2',5'-ADP Sepharose affinity chromatography. The effects of reference enzymatic inhibitors (NG-methyl-L-arginine, NG-nitro-L-arginine and N-iminoethyl-L-ornithine) on recombinant expressed proteins were not significantly different from native nitric oxide synthase enzyme preparations. L-aminoguanidine was found to be much less potent in inhibiting recombinant or native human inducible nitric oxide synthase compared to the murine isoform. These findings indicate previously unappreciated interspecies differences in the action of nitric oxide synthase enzymatic inhibitors. The functional expression of human nitric oxide synthase isoforms in a heterologous expression system allowed screening of novel inhibitors. Studies indicated that S-ethylisothiourea and 2-amino-5,6-dihydro-6-methyl-4H-1,3-thiazine were potent novel inhibitors of human nitric oxide synthases. 相似文献
26.
G. Venturini J. Z. Yang M. Ortiz J. E. Marsden 《International journal for numerical methods in engineering》2011,88(6):586-611
This paper is concerned with the classical problem of wave propagation in discrete models of nonuniform spatial resolution. We develop a new class of Replica Time Integrators (RTIs) that permit the two‐way transmission of thermal phonons across mesh interfaces. This two‐way transmissibility is accomplished by representing the state of the coarse regions by means of replica ensembles, consisting of collections of identical copies of the coarse regions. In dimension d, RTIs afford an O(nd) speed‐up factor in sequential mode, and O(nd + 1) in parallel, over regions that are coarsened n‐fold. In this work, we restrict ourselves to the solution of the 3d continuous wave equation, for both linear and non‐linear materials. By a combination of phase‐error analysis and numerical testing, we show that RTIs are convergent and result in exact two‐way transmissibility at the Courant–Friedrichs–Lewy limit for any angle of incidence. In this limit, RTIs allow step waves and high‐frequency harmonics to cross mesh interfaces in both directions without internal reflections or appreciable loss or addition of energy. The possible connections of RTIs with discrete‐to‐continuum approaches and, in particular, with the transition between molecular dynamics and continuum thermodynamics are also pointed to by way of future outlook. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
27.
The purpose of this paper is to give a local tricubic interpolation scheme in three dimensions that is both C1 and isotropic. The algorithm is based on a specific 64 × 64 matrix that gives the relationship between the derivatives at the corners of the elements and the coefficients of the tricubic interpolant for this element. In contrast with global interpolation where the interpolated function usually depends on the whole data set, our tricubic local interpolation only uses data in a neighbourhood of an element. We show that the resulting interpolated function and its three first derivatives are continuous if one uses cubic interpolants. The implementation of the interpolator can be downloaded as a static and dynamic library for most platforms. The major difference between this work and current local interpolation schemes is that we do not separate the problem into three one‐dimensional problems. This allows for a much easier and accurate computation of higher derivatives of the extrapolated field. Applications to the computation of Lagrangian coherent structures in ocean data are briefly discussed. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
28.
BF O'Donnell JR Marsden CA O'Donnell DS Sanders C Billingham 《Canadian Metallurgical Quarterly》1996,34(4):632-637
BACKGROUND: Relatively few studies have addressed the question of whether clinical estimation of melanoma thickness by palpation can accurately predict its histologic thickness. If palpability was a reliable predictor of dermal invasion, it could be used to define the surgical margin. OBJECTIVE: We sought to determine whether clinical elevation of melanoma could be used to predict the presence or absence and the degree of dermal invasion in patients with stage 1 cutaneous melanoma. METHODS: Melanomas in 165 patients were categorized by one observer as flat, just palpable, palpable, or nodular. This was compared with histologic measurements of tumor thickness. RESULTS: Overall there was significant correlation between the degree of palpability of melanoma and the presence or absence of dermal invasion (p<0.001), Breslow thickness (p<0.0001), and Clark level (p<0.001). However, the relation between palpability and Breslow thickness for invasive melanomas less than 1 mm thick was weaker (n=62, p=0.053), and the correlation between elevation and Clark level was not significant for invasive melanomas less than 4 mm thick (n=111, p>0.999). CONCLUSION: We conclude that palpability of melanoma is an inadequate guide to the presence or absence and degree of dermal invasion in melanomas less than 1 mm thick and cannot be used to determine the surgical margin. 相似文献
29.
A Schrag Y Ben-Shlomo R Brown CD Marsden N Quinn 《Canadian Metallurgical Quarterly》1998,13(6):885-894
The authors report on clinical features and mortality rates in a group of 149 patients with apparent idiopathic parkinsonism starting before the age of 40 years. Ten had juvenile parkinsonism (JP; onset before age 21 years) and 139 had young-onset Parkinson's disease (YOPD; onset at age 21 to 40 years). Included were 60 patients originally reported 10 years ago. Fifty percent of the JP group had a positive family history of parkinsonism in a first-degree relative, and clinical presentation was heterogeneous. Mortality risk was threefold that of the normal population. In the YOPD group, the mortality risk was double that of the normal population. Poor initial response to L-dopa was a risk factor for early death. In two previously reported patients, the diagnosis had been changed to multiple system atrophy and Machado-Joseph disease. After a median disease duration of 18 years, cognitive impairment was found in only 19% of YOPD patients (13% of those younger than 60 years and 43% of those 60 years or older). Age was the most important factor for development of dementia, but female sex and positive family history of parkinsonism also had more modest predictive value. After a disease duration of 10 years or less, only 5% of patients were experiencing falls and 30% freezing, but all patients had developed L-dopa-related fluctuations and dyskinesias. The authors conclude that the mortality rate in parkinsonism starting before the age of 40 is increased in comparison to the normal population and is similar to the general Parkinson's disease population. Intellectual function and postural reflexes are usually well preserved for many years despite a long history of parkinsonism and the early and frequent occurrence of treatment complications, provided the patients remain biologically and chronologically young. 相似文献
30.
The clinical features and family histories of 20 adults with dyskinetic cerebral palsy from 20 families were studied. The majority of the patients showed progressive neurological deterioration in adult life. In only three did the condition stabilise by 10 years of age and in seven there was deterioration after the age of 30. Two patients developed a secondary cervical spondylotic myelopathy. Four patients had affected relatives and there were similar proportions of affected parents and siblings. The family data suggest genetic heterogeneity with autosomal recessive and dominant variants. The existence of an X-linked form cannot be excluded, and the demonstration of an increased paternal age effect among single cases suggests that some of these may arise because of fresh dominant genetic mutation. 相似文献