Bioaccumulation, biotransformation, and metabolite formation of fipronil and chiral legacy pesticides in rainbow trout

To assess the fate of current-use pesticides, it is important to understand their bioaccumulation and biotransformation by aquatic biota. We examined the dietary accumulation and enantioselective biotransformation of the chiral current-use pesticide fipronil, along with a mixture of selected chiral [alpha-hexachlorocyclohexane (alpha-HCH), heptachlor epoxide (HEPX), polychlorinated biphenyls (PCBs) 84, 132, 174, o,p'-DDT, and o,p'-DDD] and nonchiral (p,p'-DDT, p,p'-DDD) organochlorine compounds in juvenile rainbow trout (Oncorhynchus mykiss). Fish rapidly accumulated all compounds, as measured in the carcass (whole body minus liver and GI tract) during the 32 d uptake phase, which was followed by varying elimination rates of the chemicals (half-lives (t1/2s) ranging from 0.6 d for fipronil to 77.0 d for PCB 174) during the 96 d depuration period. No biotransformation was observed for alpha-HCH, HEPX, PCB 174, o,p'-DDT, or o,p'-DDD based on consistent enantiomeric fractions (EFs) in the fish and their t1/2s falling on a log K(ow)--log t1/2 relationship established for recalcitrant contaminants in fish. p,p'-DDT and PCBs 84 and 132 were biotransformed based on the former's t1/2 position below the log K(ow)--log t1/2 relationship, and the PCBs change in EF. Fipronil was rapidly biotransformed, based on a change in EF, a t1/2 that fell below the log K(ow)--log t1//2 relationship, which accounted for 88% of its elimination, and the rapid formation of fipronil sulfone, a known metabolite. Fipronil sulfone was found to persist longer (t1/2 approximately 2 d) than its parent compound fipronil (t1/2 approximately 0.6 d) and needs to be considered in fate studies of fipronil. This research demonstrates the utilities of the log K(ow)--log t1/2 relationship as a mechanistic tool for quantifying biotransformation and of chiral analysis to measure biotransformation in fish.     

Comparison of Barriers Self-Efficacy and Perceived Behavioral Control for Explaining Physical Activity Across 1 Year Among Adolescent Girls.

The absence of longitudinal data about correlates of physical activity during adolescence has hindered the identification of key mediator variables that can be targeted by interventions. Building on the authors' previous report of a cross-sectional analysis, this study compared barriers self-efficacy and perceived behavioral control as predictors of change in 2 levels of physical activity across a 1-year period among a sample of Black and White adolescent girls (N = 1,038). Self-efficacy did not predict change in either moderate or vigorous physical activity. In contrast, perceived behavioral control exhibited a longitudinal, independent relationship with change in vigorous physical activity. The authors concluded that perceived behavioral control is an independent predictor of change in vigorous physical activity levels across a 1-year period among a sample of Black and White adolescent girls and warrants study as a potential mediator variable in interventions designed to increase or maintain physical activity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dialectical behavior therapy for binge eating disorder.

This study evaluated the use of dialectical behavior therapy (DBT) adapted for binge eating disorder (BED). Women with BED (N=44) were randomly assigned to group DBT or to a wait-list control condition and were administered the Eating Disorder Examination in addition to measures of weight, mood, and affect regulation at baseline and posttreatment. Treated women evidenced significant improvement on measures of binge eating and eating pathology compared with controls, and 89% of the women receiving DBT had stopped binge eating by the end of treatment. Abstinence rates were reduced to 56% at the 6-month follow-up. Overall, the findings on the measures of weight, mood, and affect regulation were not significant. These results support further research into DBT as a treatment for BED. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Siblings of adults with mild intellectual deficits or mental illness: Differential life course outcomes.

The present study contrasted the later life sibling relationships, patterns of family formation, and psychological distress and well-being of siblings of adults with disabilities to a nondisabled normative group. The authors identified 268 siblings of adults with mild intellectual deficits (ID) and 83 siblings of adults with mental illness (MI) from the Wisconsin Longitudinal Study (R. M. Hauser & W. H. Sewell, 1985; R. M. Hauser, J. Sheridan, & J. R. Warren, 1998), a prospective longitudinal study that followed participants from age 18 years to age 64 years. Compared with the norm (n = 791), siblings of adults with mild ID had more contact with family members and were more likely to live in the same state as the sibling with the disability but reported less affective closeness. Siblings of adults with MI reported more psychological distress, less psychological well-being, and less adaptive personality characteristics compared with the norm, particularly for siblings of men with MI. There were no differences between groups in the patterns of marriage and childbearing. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Does Class Size in First Grade Relate to Children's Academic and Social Performance or Observed Classroom Processes?

This study evaluated the extent to which first-grade class size predicted child outcomes and observed classroom processes for 651 children (in separate classrooms). Analyses examined observed child-adult ratios and teacher-reported class sizes. Smaller classrooms showed higher quality instructional and emotional support, although children were somewhat less likely to be engaged. Teachers in smaller classes rated typical children in those classes as more socially skilled and as showing less externalizing behavior and reported more closeness toward them. Children in smaller classes performed better on literacy skills. Larger classrooms showed more group activities directed by the teacher, teachers and children interacted more often, and children were more often engaged. Lower class sizes were not of more benefit (or harm) as a function of the child's family income. First-grade class size in the range typical of present-day classrooms in the United States predicts classroom social and instructional processes as well as relative changes in social and literacy outcomes from kindergarten to first grade. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Exploring inconsistencies between modal transition systems

It is commonplace to have multiple behaviour models that describe the same system but have been produced by different stakeholders or synthesized from different sources. Although in practice, such models frequently exhibit inconsistencies, there is a lack of tool support for analyzing them. There are two key difficulties in explaining why two behavioural models are inconsistent: (1) explanations often require branching structures rather than linear traces, or scenarios; and (2) there can be multiple sources of inconsistency and many different ways of explaining each one. In this paper, we present an approach that supports exploration of inconsistencies between modal transition systems, an extension to labelled transition systems. We show how to produce sound graphical explanations for inconsistencies, how to compactly represent all possible explanations in a composition of the models being compared, and how modelers can use this composition to explore the explanations encoded therein.     

Lightweight Reasoning about Program Correctness

Automated verification tools vary widely in the types of properties they are able to analyze, the complexity of their algorithms, and the amount of necessary user involvement. In this paper we propose a framework for step-wise automatic verification and describe a lightweight scalable program analysis tool that combines abstraction and model checking. The tool guarantees that its True and False answers are sound with respect to the original system. We also check the effectiveness of the tool on an implementation of the Safety-Injection System.     

Social desirability: Its relevance to the measurement of hopelessness and suicidal behavior.

Replies to J. S. Nevid's (see record 1983-11675-001) comments on an article by the present authors (see record 1982-01443-001) examining the relationship between social desirability (SD), hopelessness, and reports of suicidal ideation/behavior. Further data on the relationship of SD, hopelessness, and prediction of future suicidal behavior collected from an inpatient psychiatric population (N?=?44) are analyzed. Results are similar to those obtained in the original study, thus strengthening confidence in those results. (12 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reasons for staying alive when you are thinking of killing yourself: The Reasons for Living Inventory.

65 adults generated 72 distinct reasons for not committing suicide; these were reduced to 48 by factor analyses performed on 2 additional samples, and the items were arranged into the Reasons for Living Inventory (RFL), which requires a rating of how important each reason would be for living if suicide were contemplated. In addition, factor analyses indicated 6 primary reasons for living: Survival and Coping Beliefs, Responsibility to Family, Child-Related Concerns, Fear of Suicide, Fear of Social Disapproval, and Moral Objections. The RFL was then given to 2 additional samples, 197 Seattle shoppers (mean age 36 yrs) and 175 psychiatric inpatients (mean age 31 yrs). Both samples were divided into several suicidal (ideators and parasuicides) and nonsuicidal groups. Separate multivariate ANOVAs indicated that the RFL differentiated suicidal from nonsuicidal Ss in both samples. In the shopping-center sample, the Fear of Suicide scale further differentiated between previous ideators and previous parasuicides. In the clinical sample, the Child-Related Concerns scales differentiated between current suicide ideators and current parasuicides. In both samples, the Survival and Coping, the Responsibility to Family, and the Child-Related Concerns scales were most useful in differentiating the groups. (24 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)