Adapting application execution in CMPs using helper threads

In parallel to the changes in both the architecture domain–the move toward chip multiprocessors (CMPs)–and the application domain–the move toward increasingly data-intensive workloads–issues such as performance, energy efficiency and CPU availability are becoming increasingly critical. The CPU availability can change dynamically due to several reasons such as thermal overload, increase in transient errors, or operating system scheduling. An important question in this context is how to adapt, in a CMP, the execution of a given application to CPU availability change at runtime. Our paper studies this problem, targeting the energy-delay product (EDP) as the main metric to optimize. We first discuss that, in adapting the application execution to the varying CPU availability, one needs to consider the number of CPUs to use, the number of application threads to accommodate and the voltage/frequency levels to employ (if the CMP has this capability). We then propose to use helper threads to adapt the application execution to CPU availability change in general with the goal of minimizing the EDP. The helper thread runs parallel to the application execution threads and tries to determine the ideal number of CPUs, threads and voltage/frequency levels to employ at any given point in execution. We illustrate this idea using four applications (Fast Fourier Transform, MultiGrid, LU decomposition and Conjugate Gradient) under different execution scenarios. The results collected through our experiments are very promising and indicate that significant EDP reductions are possible using helper threads. For example, we achieved up to 66.3%, 83.3%, 91.2%, and 94.2% savings in EDP when adjusting all the parameters properly in applications FFT, MG, LU, and CG, respectively. We also discuss how our approach can be extended to address multi-programmed workloads.     

Proteomic examination of Leishmania chagasi plasma membrane proteins: Contrast between avirulent and virulent (metacyclic) parasite forms

Purpose: About two million new cases of leishmaniasis with 50 000 associated deaths occur worldwide each year. Promastigotes of the causative Leishmania spp. develop from the procyclic stage to the highly virulent metacyclic stage within the sand fly vector. We hypothesized that proteins important for promastigote virulence might be uniquely represented in the plasma membrane of metacyclic, but not procyclic, promastigotes. Experimental design: Procyclic (logarithmic) promastigotes and purified metacyclic promastigotes from stationary phase cultures of Leishmania chagasi were used to prepare membrane preparations either by surface biotinylation‐streptavidin affinity separation or by octyl glucoside detergent extraction. Results: These membrane fractions were enriched over 130‐ and 250‐fold, respectively, as estimated by Western blotting for the plasma membrane's major surface protease. Hundreds or dozens of proteins were identified by LC‐MS/MS in the surface biotinylation or detergent extraction, respectively. Confocal microscopy suggested the difference between the lists was due to the fact that proteins localized both on the surface membrane and within the flagellar pocket were accessible to surface biotinylation, whereas only proteins on the membrane were obtained by detergent extraction. Using detergent extraction, we found different proteins were present in membranes of the procyclic stage compared to metacyclic stage promastigotes. Several dozen were stage specific. Conclusions and clinical relevance: These data provide a foundation for identifying virulence factors in the plasma membranes of Leishmania spp. promastigotes during metacyclogenesis.     

Leader’s dilemma game: An experimental design for cyber insider threat research

One of the problems with insider threat research is the lack of a complete 360° view of an insider threat dataset due to inadequate experimental design. This has prevented us from modeling a computational system to protect against insider threat situations. This paper provides a contemporary methodological approach for using online games to simulate insider betrayal for predictive behavioral research. The Leader’s Dilemma Game simulates an insider betrayal scenario for analyzing organizational trust relationships, providing an opportunity to examine the trustworthiness of focal individuals, as measured by humans as sensors engaging in computer-mediated communication. This experimental design provides a window into trustworthiness attribution that can generate a rigorous and relevant behavioral dataset, and contributes to building a cyber laboratory that advances future insider threat study.     

Optimization of Geoscience Laser Altimeter System waveform metrics to support vegetation measurements

The Geoscience Laser Altimeter System (GLAS) has collected over 250 million measurements of vegetation height over forests globally. Accurate vegetation heights can be determined using waveform metrics that include vertical extent and extent of the waveform's trailing and leading edges. All three indices are highly dependent upon the signal strength, background noise and signal-to-noise ratio of the waveform, as the background noise contribution to the waveforms has to be removed before their calculation. Over the last six years, GLAS has collected data during thirteen observation periods using illumination from three different lasers. The power levels of these lasers have changed over time, resulting in variable signal power and noise characteristics. Atmospheric conditions vary continuously, also influencing signal power and noise.To minimize these effects, we optimized a noise coefficient which could be constant or vary according to observation period or noise metric. This parameter is used with the mean and standard deviation of the background noise to determine a noise level threshold that is removed from each waveform. An optimization analysis was used with a global dataset of waveforms that are near-coincident with waveforms from other observation periods; the goal of the optimization was to minimize the difference in vertical extent between spatially overlapping GLAS observations. Optimizations based on absolute difference in height led to situations in which the total extent was minimized as well; further optimizations reduced a normalized difference in height extent. The simplest optimizations were based on a constant value to be applied to all observations; noise coefficients of 2.7, 3.2, 3.4 and 4.0 were determined for datasets consisting of global forests, global vegetation, forest in the legal Amazon basin and boreal forests respectively. Optimizations based on the power level or the signal-to-noise ratio of waveforms best minimized differences in waveform extent, decreasing the percent root mean squared height difference by 25-54% over the constant value approach. Further development of methods to ensure temporal consistency of waveform indices will be necessary to support long-term satellite lidar missions and will result in more accurate and precise estimates of canopy height.     

Kinematics of heelstrike during walking and carrying: implications for slip resistance testing

Slip resistance measurements of shoes and floors are used to evaluate the potential for slip and fall injuries. These measurements are believed to have increased validity when they more closely reflect actual heelstrike biomechanics during locomotion. The purpose of this study was to describe heelstrike kinematics during load carrying to provide data towards improved slip resistance testing. Foot kinematics during load carrying (unladen and carrying from 0 to 13.5 kg) at various cadences (70, 90, 100 steps/min) was recorded. Measures before, during and after heelstrike were analysed. Cadence was an important predictor for all variables measured, associated with changes from 13% to over 100%. The load carried was an important predictor for only the heel slip distance after heelstrike, but this effect needs to be investigated further. These results can be used to improve the fidelity of slip resistance measurements, which is critical to reduce slip and fall injuries in the workplace or during activities of daily living.     

Large displays enhance optical flow cues and narrow the gender gap in 3-D virtual navigation

OBJECTIVE: Existing reports suggest that males significantly outperform females in navigating 3-D virtual environments. Although researchers have recognized that this may be attributable to males and females possessing different spatial abilities, most work has attempted to reduce the gender gap by providing more training for females. In this paper, we explore using large displays to narrow the gender gap within these tasks. BACKGROUND: While evaluating various interaction techniques, we found that large displays affording wider fields of view seemed to improve virtual navigation performance in general and, additionally, to narrow the gender gap that existed on standard desktop displays. METHOD: We conducted two experiments (32 and 22 participants) exploring the individual contributions of display and geometric fields of view to the observed effects as well as isolating factors explaining performance increases seen on the large displays. RESULTS: We show that wider fields of view on large displays not only increase performance of all users on average but also benefit females to such a degree as to allow them to perform as well as males do. We further demonstrate that these benefits can be attributed to better optical flow cues offered by the large displays. CONCLUSION: These findings provide a significant contribution, including recommendations for the improved presentation of 3-D environments, backed by empirical data demonstrating performance benefits during navigation tasks. APPLICATION. Results can be used to design systems that narrow the gender gap in domains such as teleoperation and virtual environments for entertainment, virtual training, or information visualization.     

Assay of aflatoxin in peanuts and peanut products using acetone-hexane-water for extraction

A quantitative method is described for the assay of aflatoxin in peanut products. The procedure involves extraction of aflatoxin from the sample with a homogeneous acetone-hexane-water solvent mixture followed by purification of the extract by phasic extraction of the aflatoxin with aqueous sodium chloride and then with chloroform. The purified chloroform extract is analyzed by thin-layer chromatography by comparison of the intensity of fluorescence of any aflatoxin with the intensity of a known standard. The aflatoxin analyses of peanuts were found to be very variable due to sampling, and this variability has been greatly reduced by finely grinding and thoroughly mixing 2 kg of the sample before removal of an aliquot for assay. The method is sensitive to approximately 2 parts per billion. Honorable mention, Bond Award competition. Presented at AOCS Meeting, Chicago, Illinois, October, 1964. So. Reg. Res. Lab., New Orleans, Louisiana, one of the laboratories of the So. Utiliz. Res. and Dev. Div., ARS, USDA.     

Ignitable Liquid Classification and Identification Using the Summed-Ion Mass Spectrum

Abstract

The mass spectra calculated by summing the intensities of each nominal mass over all chromatographic times, the summed ion spectra, were calculated for a set of 440 commercially available ignitable liquids that had been analyzed by gas chromatography–mass spectrometry. Each ignitable liquid is generally comprised of a mixture of chemicals, and the mixtures may be very complex in some cases, e.g., petroleum distillates, gasoline, etc. The summed ion spectra were evaluated to determine if they contained sufficient information content to allow their use for rapid and accurate identification of the ignitable liquid in a database or library. The summed ion nominal mass spectra were encoded in one bit per channel at 1% transition intensity and a set of 96,580 unique pairwise comparisons were made between spectra, resulting in an average of approximately 50 differing channels per comparison. A subset of 62 summed ion spectra were further compared by a similarity metric and found by cluster analysis to group closely along the ASTM ignitable liquid classification scheme. Receiver operator characteristic analysis of the use of the similarity index in combination with the summed ion spectra was shown to provide 99% probability of correct liquid identification and 95% probability of correct ASTM classification by primary and sub-class. Interlaboratory tests found 95% probability of correct liquid identification and 85% probability of correct ASTM classification at the primary class level. These results demonstrate the use of the summed ion spectrum as a first step in the rapid identification of an ignitable liquid by database or library searching.