Early diagnosis remains highly important for efficient cancer treatment,and hence,there is significant interest in the development of effective imaging strategies.This work reports a new multimodal bioimaging method for accurate and rapid diagnosis of cancer cells by introducing aqueous Fe2+ and Zn2+ ions into cancer cells (i.e.,HeLa,U87,and HepG2 cancer cells).We found that the biocompatible metal ions Fe2+ and Zn2+ forced the cancer cells to spontaneously synthesize fluorescent ZnO nanoclusters and magnetic Fe3O4 nanoclusters.These clusters could then be used for multimodal cancer imaging by combining fluorescence imaging with magnetic resonance imaging and computed tomography imaging.Meanwhile,for normal cells (i.e.,L02) and tissues,neither fluorescence nor any other obvious difference could be detected between preand post-injection.This multimodal bioimaging strategy based on the in situ biosynthesized Zn&Fe oxide nanoclusters might therefore be useful for early cancer diagnosis and therapy. 相似文献
Card-based systems are simple, effective means of controlling production. Yet most systems concentrate on controlling the shop floor. They neglect other planning tasks, like estimating short, feasible due dates during customer enquiry management. A card-based version of the workload control concept for job shops – COBACABANA (COntrol of BAlance by CArd-BAsed Navigation) – was proposed in the literature to overcome this shortcoming. COBACABANA uses cards for due date setting and order release, making it a potentially important solution for small shops with limited resources. But many such firms operate as flow shops rather than job shops. Research demonstrated that COBACABANA’s release mechanism must be adapted if applied to a pure flow shop, but its approach to due date setting has not been evaluated in such an environment. We show COBACABANA has the potential to improve pure flow shop performance, but its due date setting procedure should be adapted compared to job shops. In a flow shop, due date estimation can also be further simplified by considering the load awaiting release to the first (gateway) station only while maintaining most performance benefits. The results are important for all card-based systems that aim to stabilise work-in-process, including kanban and ConWIP (Constant Work-in-Process). 相似文献
One of the key functions of Workload Control is order release. Jobs are not released immediately onto the shop floor – they are withheld and selectively released to create a mix of jobs that keeps work-in-process within limits and meet due dates. A recent implementation of Workload Control’s release method highlighted an important issue thus far overlooked by research: How to accommodate re-entrant flows, whereby a station is visited multiple times by the same job? We present the first study to compare the performance of Workload Control both with and without re-entrant flows. Simulation results from a job shop model highlight two important aspects: (i) re-entrant flows increase variability in the work arriving at a station, leading to a direct detrimental effect on performance; (ii) re-entrant flows affect the release decision-making process since the load contribution of all visits by a job to a station has to fit within the norm. Both aspects have implications for practice and our interpretation of previous research since: (i) parameters given for work arriving may significantly differ from those realised; (ii) increased workload contributions at release mean that prior simulations may have been unstable, leading to some jobs never being released. 相似文献
Profiling of the electrical properties of nanowires (NWs) and NW heterocontacts with high spatial resolution is a challenge for any application and advanced NW device development. For appropriate NW analysis, we have established a four-point prober, which is combined in vacuo with a state-of-the-art vapor-liquid-solid preparation, enabling contamination-free NW characterization with high spatial resolution. With this ultrahigh-vacuum-based multi-tip scanning tunneling microscopy (MT-STM), we obtained the resistance and doping profiles of freestanding NWs, along with surface-sensitive information. Our in-system 4-probe STM approach decreased the detection limit for low dopant concentrations to the depleted case in upright standing NWs, while increasing the spatial resolution and considering radial depletion regions, which may originate from surface changes. Accordingly, the surface potential of oxide-free GaAs NW {112} facets has been estimated to be lower than 20 mV, indicating a NW surface with very low surface state density.
The structuring of surface meshes is a labor intensive task in reverse engineering. For example, in CAD, scanned triangle meshes must be divided into characteristic/uniform patches to enable conversion into high-level spline surfaces. Typical industrial techniques, like rolling ball blends, are very labor intensive.We provide a novel, robust and quick algorithm for the automatic generation of a patch layout based on a topology consistent feature graph. The graph separates the surface along feature lines into functional and geometric building blocks. Our algorithm then thickens the edges of the feature graph and forms new regions with low varying curvature. Further, these new regions-so-called fillets and node patches-will have highly smooth boundary curves, making the algorithm an ideal preprocessor for a subsequent spline fitting algorithm. 相似文献