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41.
Penel Simon; Morrison R.Gwilym; Dobson Paul D.; Mortishire-Smith Russell J.; Doig Andrew J. 《Protein engineering, design & selection : PEDS》2003,16(12):957-961
We analysed the length distributions of different types of ß-strandin a high resolution, non-homologous set of 500 protein structures,finding differences in their mean lengths. Antiparallel edgestrands in strandturnstrand motifs show a preferencefor an even number of residues. This propensity is enhancedif the length is corrected for ß-bulges, which insertan extra residue into the strand. Residues in antiparallel edgeß-strands alternate between being in hydrogen bondedand non-hydrogen bonded rings. Antiparallel edges with an evennumber of residues are more likely to have their final ßresidue in a non-hydrogen bonded ring. This suggests that non-hydrogenbonded rings are intrinsically more stable than hydrogen bondedrings, perhaps because its side chain packing is closer. Therefore,we suggest that a simple way to increase ß-hairpinstability, or the stability of an antiparallel edge strand,is to have a non-hydrogen bonded ring at the end of the strand. Received June 19, 2003; revised October 25, 2003; accepted November 7, 2003 相似文献
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43.
Gary W. Delaney Paul W. Cleary Marko Hilden Rob D. Morrison 《Chemical engineering science》2012,68(1):215-226
We investigate the flow of a granular material over a vibrated horizontal screen. We perform a direct quantitative comparison, across a range of operating conditions, between laboratory scale experiments and simulations using the discrete element method (DEM). We test the extent to which the commonly employed DEM approximation of particles being spherical affects the ability of the model to realistically reproduce the behaviour of industrial screening systems where the particles are generally non-spherical in shape.The simulation geometry and input particle size distribution are set up to exactly match the experimental system, which consists of a horizontal screen with a wire mesh cloth onto which quarry rock is fed at a series of input flow rates. The screen is vibrated, causing the granular bed to flow over the deck and vertically stratify with finer material passing through the screen, where it is collected in a series of bins located along the length of the screen. The size distribution of the material flowing through each section of the screen is found by analyzing the contents of each collection bin.The best agreement is found for very low flow rates, where the vast majority of the below aperture size material is rapidly captured just after it enters the screen in both the simulation and experiment. At higher flow rates, significant quantitative errors are found with the over-prediction of the flow rate through the screen for near grate sized particles. This is attributed to the higher rate of percolation through the bed and the easier capture by the screen surface of the spherical shaped material. The near aperture sized spherical particles also show a very strong tendency to peg the screen, becoming trapped in the screen openings and limiting further flow through those parts the screen. The use of spherical particles in the DEM simulation of vibrating screens is therefore found to be inadequate for modelling realistic flow and separation of particles that are not actually spherical. 相似文献
44.
Ben W. Morrison Mark W. Wiggins Glenn Porter 《International journal of human-computer interaction》2013,29(4):297-316
This study examined trainee crime-scene investigators' preference for, and accuracy in using, four different computer-based decision support interface designs, each of which incorporated a different reduced processing information acquisition strategy. The interfaces differed on the basis of the number of options that could be considered simultaneously and the level of control that could be exercised over the number and sequence in which feature values were accessed. Forty trainee investigators completed six decision scenarios in which they were asked to acquire information and formulate a decision by selecting one of three options. The study comprised two phases, the first of which involved familiarizing participants with each of the four interface designs and collecting performance and subjective data. The second phase involved trainees selecting one of the four interfaces to engage in a fifth and sixth decision scenario involving high or low levels of time-pressure. The results indicated that the “all options, full control” interface was the preferred option in the low time-pressure condition. Although the strategy remained the most frequently selected in the high time-pressure condition, this preference was not significant. It was concluded that the perceptions of difficulty and the degree of user control over information acquisition were more important than perceived efficiency in the selection of computer-based interface designs. The outcomes have implications for the design of decision support systems. 相似文献
45.
Distributed termination detection (DTD) algorithms are important since they detect globally stable states in distributed computations.
Here we introduce a new DTD mechanism, the Doomsday protocol together with its proof of correctness. Doomsday is generic since
it forms the basis for a number of new and existing DTD algorithms for which the correctness proof may be reused. The paper
describes the Doomsday protocol, provides its formal proof, derives one new DTD algorithm and shows how other hitherto unrelated
algorithms, Dijkstra–Scholten, Task Balancing and Credit Recovery, can be derived from the protocol. The paper concludes by
examining various properties of the protocol in the context of existing DTD algorithms.
This work was supported in part by Visiting Fellowship grant EPSRC GR/R84481/01 “The Doomsday Protocol” and by Australian
Research Council ARC Linkage International Grant LX0349049 “Extending a Family of Garbage Collectors”. 相似文献
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47.
Wright J. Hartman F. Cooper B. Maxwell S. Yen J. Morrison J. 《Robotics & Automation Magazine, IEEE》2006,13(2):37-45
The rover sequencing and visualization program (RSVP) suite of tools has been a critical factor in the success of the Mars exploration rover (MER) missions. It would be impossible to prepare the large command loads each sol without the capabilities that it possesses. It has proven to be robust and easy to use and capable of answering key questions about sequence validity and constraints. Certainly, training is required to use RSVP, but this is primarily in the general area of command sequencing and rover operations. Once these concepts are understood, RSVP feels natural for building sequences. RSVP has met its prime requirements of supporting rapid assimilation and understanding of the terrain and operational constraints, rapid sequence generation and validation, and production of documentation and archival products. This can be seen in the very limited number of sols lost due to errors in the command sequences. The success of the MER mission and the tremendous amount of science data collected attest to the capability of RSVP. 相似文献
48.
McAllister Daniel J.; Kamdar Dishan; Morrison Elizabeth Wolfe; Turban Daniel B. 《Canadian Metallurgical Quarterly》2007,92(5):1200
The objective of this study was to empirically disentangle role perceptions related to organizational citizenship behavior (OCB) that have been confounded in past research, investigate their unique relationships with both an affiliative (helping) and a challenging (taking charge) form of OCB, and determine their relative importance in explaining these 2 forms of OCB. The authors also examined whether role discretion and role breadth independently moderate the procedural justice-to-OCB relationship. The authors surveyed 225 engineers in India and their direct supervisors. The results showed that 3 of the 4 facets of OCB role perception explain unique variance in either helping or taking charge, and that role breadth moderates the relationships between procedural justice and both helping and taking charge. The authors discuss implications of these findings for OCB theory and research, as well as for managerial practice. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
49.
Tony Carr Author Vitae Andrew Morrison Author Vitae Author Vitae Andrew Deacon Author Vitae 《Computers and Composition》2007,24(3):266-284
Wikis represent flexible tools functioning as open-ended environments for collaboration while also offering process and group writing support. Here we focus on a project to innovate the use of wikis for collaborative writing within student groups in a final-year undergraduate political science course. The primary questions guiding our research were in what ways could wikis assist collaborative learning in an undergraduate course in political science and how we could support educators’ in the effective use of wikis? Curiously, wikis may serve as a mediating artifact for collaborative writing even among students who are reluctant to post online drafts. The paper raises questions concerning the nature and limits of lecturer and tutor power to deliver transformative educational innovations in relation to the capacity of students to embrace, comply with, or resist such innovation. In analysing the negotiation of the use of wikis in the course by and among the lecturer, tutors, and students, we draw on two principles in activity theory, which Yrjö Engeström argued are central to his model of expansive learning: multi-voicedness and contradictions [Engeström, Yrjö. (1987). Learning by expanding: An activity-theoretical approach to developmental research. Helsinki: Orienta-Konsultit; Engeström, Yrjö. (2001). Expansive learning at work: Toward an activity theoretical reconceptualization. Journal of Education and Work14(1), 133-156.]. We add a third principle, transparency, to more fully capture what we observed. 相似文献
50.
Jayan Ozhikandathil Andrew Morrison Muthukumaran Packirisamy Rolf W��thrich 《Microsystem Technologies》2011,17(3):373-380
Controlling precisely the depth in glass micro-drilling by spark assisted chemical engraving (SACE) remains challenging, particularly for low depths. The possibility of using an electrically conductive material as an etch-stop layer for SACE gravity-feed drilling is investigated in this paper. Micromachining with constant DC and pulsed DC of 30–35 μm thick SiO2 deposited on low resistive silicon substrate demonstrated the etch-stop function of the conductive silicon. Measurements of etch rates and hole profiles along with scanning electron microscope imaging revealed the mechanism underlying the etch-stop process. Low resistive silicon is demonstrated to be a good etch-stop layer for SACE gravity-feed drilling. Demonstration of machining of SiO2 layer on silicon as a substrate and an etch-stop layer opens up new possibilities to adapt SACE for developing devices on silicon platform. 相似文献