The temperature ranges for maximum effectiveness of grain growth inhibitors in WC–Co alloys

In order to more effectively control the WC grain growth during liquid phase sintering of submicron WC–Co alloys, the temperature ranges where common grain growth inhibitors are most active have been determined. In the study, small additions (0.5% by weight) of TiC, TaC, NbC, VC, and Cr₃C₂ were added to WC–6Co and WC–10Co alloys. In some cases, a small amount of coarse WC powder was added to simulate the effect of discontinuous grain growth. The powder compacts were vacuum sintered at temperatures ranging from 1300 to 1575 °C. The magnetic coercivity and microstructure results indicated that VC is equally effective in limiting continuous grain growth for all temperatures within the temperature range while the other inhibitors become more effective with temperature. VC was also found to be the most effective inhibitor of discontinuous grain growth. The results of the investigation are expressed in terms of the effectiveness of grain growth inhibition as determined by microstructural analysis, magnetic coercivity and hardness.     

Rat insulinoma-derived pancreatic beta-cells express a functional leptin receptor that mediates a proliferative response

In addition to its interaction at hypothalamic sites to affect feeding and energy expenditure, leptin has been shown to exhibit a proliferative response in erythropoietic cells. The functional leptin receptor is also present in pancreatic islets and we now demonstrate that a commonly used clonal insulin secreting beta-cell line, RINm5F, expresses high levels of the Ob-Rb mRNA. Leptin causes an increase in tyrosine phosphorylation of a number of intracellular proteins and a dose related (10 nM-200 nM) increase in expression of the immediate-early gene, c-fos. This precedes a leptin induced proliferative response in serum-deprived RINm5F cells, which suggests that leptin might be involved in the complex regulation of proliferation of the pancreatic beta-cell.     

Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice

Deafness is the most common form of sensory impairment in humans. Mutations in unconventional myosins have been found to cause deafness in humans and mice. The mouse recessive deafness mutation, Snell's waltzer, contains an intragenic deletion in an unconventional myosin, myosin VI (locus designation, Myo6). The requirement for Myo6 for proper hearing in mice makes this gene an excellent candidate for a human deafness disorder. Here we report the cloning and characterization of the human unconventional myosin VI (locus designation, MYO6) cDNA. The MYO6 gene maps to human chromosome 6q13. The isolation of the human gene makes it now possible to determine if mutations in MYO6 contribute to the pathogenesis of deafness in the human population.     

Placement of Substrate Contacts to Minimize Substrate Noise in Mixed-Signal Integrated Circuits

The placement of substrate contacts in epi and non-epi technologies is analyzed in order to control and reduce the substrate noise amplitude and spreading. The choice of small or large substrate contacts or rings for each of the two major technologies is highlighted. Design guidelines for placing substrate contacts so as to improve the noise immunity of digital circuits in mixed-signal smart-power systems are also presented.     

Assignment and Allocation Optimization of Partially Multiskilled Workforce

Multiskilling is a workforce strategy that has been shown to reduce indirect labor costs, improve productivity, and reduce turnover. A multiskilled workforce is one in which the workers possess a range of skills that allow them to participate in more than one work process. In practice, they may work across craft boundaries. The success of multiskilling greatly relies on the foreman’s ability to assign workers to appropriate tasks and to compose crews effectively. The foreman assigns tasks to workers according to their knowledge, capabilities, and experience on former projects. This research investigated the mechanics of allocating a multiskilled workforce and developed a linear programming model to help optimize the multiskilled workforce assignment and allocation process in a construction project, or between the projects of one company. It is concluded that the model will be most useful in conditions where full employment does not exist; however, it is also useful for short term allocation decisions. By running the model for various simulated scenarios, additional observations were made. For example, it is concluded that, for a capital project, the benefits of multiskilling are marginal beyond approximately a 20% concentration of multiskilled workers in a project workforce. Benefits to workers themselves become marginal after acquiring competency in two or three crafts. These observations have been confirmed by field experience. Extension of this model to allocation of multifunctional resources, such as construction equipment, should also be possible.     

Characterizing user performance in command-driven dialogue

To learn to use an interactive system, a person typically has to acquire a good deal of new knowledge. The ease of learning will depend on the extent to which the design of the task and the interface capitalizes on the user's pre-existing knowledge and his or her cognitive capabilities for learning. This paper explores the nature of both design decisions and user learning with a command-based system. Three studies were conducted, all involving a task in which secret messages were decoded by means of a sequence of commands (based on the task used by Barnard et al. In Study I, software specialists designed command structures for the task and gave reasons for their choices. In Study II, naive subjects chose between alternative command terms. In Study TTI, subjects learned to use interactive versions of the task in which dialogue factors (command terms and argument structures) were systematically varied. The results enabled the development of user knowledge of the system to be specified in detail. Comparisons across the three studies highlighted the diversity of the factors determining both design decisions and user behaviour.     

Some changes in the constituents upon heating a model meat flavour system

Percentage changes in the amino acid content upon heating with different components in a synthetic model meat flavour mixture were followed during different stages in development of the system. Heating of ten different amino acids with a simple sugar mixture (glucose, ribose and xylose) resulted in losses of approximately 95, 58, 38 and 37% of the cysteine, methionine, leucine and isoleucine, respectively, whereas the other amino acids decreased by 19–31%, but the ammonia (NH₃) content by only 5%. On heating gelatin with the simple sugar mixture, tyrosine and phenylalanine losses amounted to about 58 and 40%, respectively, while the other amino acids declined by 27–37% and the NH₃ content by some 12%. Heating of the composite model system (gelatin, added amino acids and simple sugars) resulted in losses of about 94, 60 and 55% of the cysteine, methionine and histidine, respectively, while the other amino acids decreased by 20–35% and the NH₃ content by 15%. The possible role of some of the amino acids in the development of the synthetic meat flavour system is discussed in view of these findings.     

PLATO DCS, an interactive computer system for personal counseling: Further development and evaluation.

Two newly developed solutions components are described as additional resources for users of the PLATO computer-based Dilemma Counseling System (PLATO DCS). The specific and structural dilemma solutions components contain 69 representative life-choice problems and over 400 specific and general solutions that assist users in solving their psychological dilemmas. Computer-based dilemma counseling was examined empirically by assessing self-reported problem improvement in 2 groups of undergraduate students treated on PLATO DCS (n?=?48) or in a no-contact control group (n?=?62). Ss who used PLATO DCS showed significantly greater improvement in their problems than the control group 1 wk after treatment. This difference tended to persist 1 mo after treatment. (23 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The mechanisms of suppression and enhancement in comprehension.

The goal of comprehension is to build coherent mental representations or structures. These structures represent clauses, sentences, paragraphs, passages, and other meaningful units. Thus, comprehending a clause requires building a mental structure to represent what that clause is about; comprehending a sentence requires building a mental structure to represent what that sentence is about; comprehending a passage requires building a mental structure to represent what that passage is about. In Gernsbacher (1990), I described a simple framework for understanding how comprehenders build mental structures during comprehension. I call this framework, the Structure Building Framework. (PsycINFO Database Record (c) 2010 APA, all rights reserved)