Development of Anticandidal Delivery Systems: (I) Anticandidal Activities of Antifungal Agents and Synergistic Combination with Other Drugs

Susceptibility testing with antifungal agents, e. g., minimum inhibitory concentration (MIC) determination, is performed to obtain reliable data that permit selection of the most suitable agents for treatment of an infective condition. To determine the drugs that provide maximum effectiveness against oral candidiasis, the MICs of various antifungal agents were determined. Also, synergism between two chosen antifungal agents was evaluated, and the effect of benzocaine, an anesthetic, and hydrocortisone, an antiinflammatory agent, on their MICs was examined. It was observed that among all the drugs tested, clotrimazole was the most promising candidate for use as an oral local antifungal. The combination of clotrimazole and chlorhexidine resulted in a decrease in the MIC. While the addition of hydrocortisone to this combination resulted in a slight increase in the MIC, the inclusion of benzocaine resulted in a substantial decrease in the MIC of the antifungal agent combination.     

A unified model for dislocation nucleation, dislocation emission and dislocation free zone

In this paper, a unified model for dislocation nucleation, emission and dislocation free zone is proposed based on the Peierls framework. Three regions are identified ahead of the crack tip. The emitted dislocations, located away from the crack tip in the form of an inverse pileup, define the plastic zone. Between that zone and the cohesive zone immediately ahead of the crack tip, there is a dislocation free zone. With the stress field and the dislocation density field in the cohesive zone and plastic zone being, respectively, expressed in the first and second Chebyshev polynomial series, and the opening and slip displacements in trigonometric series, a set of nonlinear algebraic equations can be obtained and solved with the Newton-Raphson Method. The results of calculations for pure shearing and combined tension and shear loading after dislocation emission are given in detail. An approximate treatment of the dynamic effects of the dislocation emission is also developed in this paper, and the calculation results are in good agreement with those of molecular dynamics simulations.Presented at the Far East Fracture Group (FEFG) International Symposium on Fracture and Strength of Solids, 4–7 July 1994 in Xi'an, China.     

Sterilization of heparinized Cuprophan hemodialysis membranes

The effects of sterilization of dry heparinized Cuprophan hemodialysis membranes by means of ethylene oxide (EtO) exposure, gamma irradiation, or steam on the anticoagulant activity and chemical characteristics of immobilized heparin and the permeability of the membrane were investigated. Sterilization did not result in a release of heparin or heparin fragments from heparinized Cuprophan. Sterilization of heparinized Cuprophan by means of EtO exposure and gamma irradiation induced a slight, insignificant decrease of the anticoagulant activity. In contrast, steam-sterilized heparinized Cuprophan showed a higher anticoagulant activity than unsterilized heparinized Cuprophan, which was most likely caused by cleavage of some of the covalent bonds between heparin and Cupropha. The effects of sterilization on the permeability of unmodified Cuprophan and heparinized Cuprophan were compared. The permeability of unmodified Cuprophan for vitamin B₁₂ (Vit B₁₂) and sulfobromophthalein (SBP) was reduced by 20–35% after EtO exposure and gamma irradiation and was reduced by 90–95% after steam sterilization. The water permeability of unmodified Cuprophan remained the same after EtO exposure and gamma irradiation but also dramatically reduced after steam sterilization. These reductions were ascribed to the collapse of pores of the membrane. The permeability of heparinized Cuprophan was not affected by EtO exposure and gamma irradiation but dramatically reduced after steam sterilization, although to a lesser extent than in the case of unmodified Cuprophan. Apparently, the presence of immobilized heparin (partially) prevented the collapse of pores during sterilization. Gamma irradiation was recommended as the preferred method of sterilization for heparinized Cuprophan.     

Recent developments in the extrusion of helical gears

With an improved die, a method for manufacturing gears by means of tube extrusion has been developed to a stage where, without noticeable wear of the die, 40,000 workpieces can be manufactured. The paper presents a numerical analysis of the stresses and deflection of the die, offering also a comparison between the modified and the conventional symmetric orifice. Based on the results obtained and using recent work on crack prediction for extrusion dies, the area most prone to rupture is determined. Moreover, a concept for the precorrection of the die is offered to improve the tooth quality of the gears.     

Responses of practicing psychologists to a web site developed to promote empirically supported treatments.

Increased adoption of empirically supported treatments (ESTs) has been hindered in part by inadequate and inconvenient access to EST information and training. To improve diffusion of ESTs, the authors developed a Web application to provide practitioners with concise information by disorder on ESTs. The resulting site, therapyadvisor.com, was evaluated by 239 practicing psychologists to assess the usefulness of the site and explore possible interactions of EST attitudes on ratings of usefulness and impact. Two thirds of participants indicated using ESTs in practice, and limited time and resources were cited as primary barriers to EST adoption. The Web application was rated positively by most participants and was reported to increase awareness of and commitment to try ESTs among approximately 60% of participants. The results of this project support the feasibility of a Web application to increase diffusion and promote further adoption of ESTs. Technological and e-learning advances are promising directions for encouraging the adoption of ESTs specifically and evidence-based practice generally, particularly among busy practitioners who have inadequate time and resources for more traditional forms of dissemination and training. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Post-Supervised Template Induction for Information Extraction from Lists and Tables in Dynamic Web Sources

Dynamic web sites commonly return information in the form of lists and tables. Although hand crafting an extraction program for a specific template is time-consuming but straightforward, it is desirable to automatically generate template extraction programs from examples of lists and tables in html documents. Supervised approaches have been shown to achieve high accuracy, but they require manual labelling of training examples, which is also time consuming. Fully unsupervised approaches, which extract rows and columns by detecting regularities in the data, cannot provide sufficient accuracy for practical domains. We describe a novel technique, Post-supervised Learning, which exploits unsupervised learning to avoid the need for training examples, while minimally involving the user to achieve high accuracy. We have developed unsupervised algorithms to extract the number of rows and adopted a dynamic programming algorithm for extracting columns. Our method achieves high performance with minimal user input compared to fully supervised techniques.     

Boron removal by titanium addition in solidification refining of silicon with Si-Al melt

In order to effectively remove B from Si for its use in solar cells, a process involving B removal by solidification refining of Si using a Si-Al melt with Ti addition was investigated. For clarifying the effect of Ti addition on B removal from the Si-Al melt, TiB₂ solubilities in Si-64.6 at. pct Al melt at 1173 K and Si-60.0 at. pct Al melt at 1273 K were determined by measuring the equilibrium concentrations of B and Ti in the presence of TiB₂ precipitates. The small solubilities of TiB₂ in the Si-Al melt indicate the effective removal of B from the Si-Al melt by Ti addition. Further, solidification experiments of Si-Al alloys containing B by Ti addition were performed, and the effect of Ti addition on the solidification refining of Si with the Si-Al melt was successfully confirmed.     

An explanation of disproportionate growth using linear 3-dimensional informetrics and its relation with the fractal dimension

Summary We study new and existing data sets which show that growth rates of sources usually are different from growth rates of items. Examples: references in publications grow with a rate that is different (usually higher) from the growth rate of the publications themselves; article growth rates are different from journal growth rates and so on. In this paper we interpret this phenomenon of “disproportionate growth' in terms of Naranan's growth model and in terms of the self-similar fractal dimension of such an information system, which follows from Naranan's growth model. The main part of the paper is devoted to explain disproportionate growth. We show that the “simple' 2-dimensional informetrics models of source-item relations are not able to explain this but we also show that linear 3-dimensional informetrics (i.e. adding a new source set) is capable to model disproportionate growth. Formulae of such different growth rates are presented using Lotkaian informetrics and new and existing data sets are presented and interpreted in terms of the used linear 3-dimensional model.     

A Programmable Pulse Sequence Generator for an NMR Relaxometer

A pulse sequence generator for NMR relaxometer is described. The operation mode is loaded into the internal memory of the device by a program from a personal computer via a PCI bus. The project is realized on two MAX7000S and Cyclone (Altera) chips using the Qartus II 4.0 software. The basic parameters of the device are as follows: the minimal pulse length is 50 ns, the time resolution is 10 ns, the maximum number of pulses is 1024, and the number of controlled output channels is 8. This device, operating in the automatic mode as part of the hardware-software NMR system, makes possible recording, processing, and storing experimental results in electronic form.     

Mass customization of medical devices and implants: state of the art and future directions

The medical field is one in which the need for customization can be clear cut, as providing tailored devices and implants for unique physiologies can provide for a better overall treatment than the use of 'off the shelf' devices and implants. Customization in the production of medical products can be roughly divided into consideration of medical devices, and of implantable parts or systems. The present paper outlines the current state of the art in both of these areas, presents details of projects that are ongoing at the University of Leeds and outlines future research directions.