Wearable computers as a virtual environment interface for people with visual impairment

People who are totally blind or who have vevere visual impairments (e.g. less than 20/200 acuity, central macular scotomas, or advanced diabetic retinopathy) see the environment in a fashion that may be completely foreign to those who operate in a very visual fashion. For this population, the visual complexity of the environment is not a concern. What is of concern are salient features found within the environment that relate to their ability to navigate successfully in, and/or interact with, the environment as needed. Toward the purpose of representing these salient features in comprehensive form, investigators at the Atlanta Veterans Affairs Research and Development Center are employing wearable computer technology to develop a virtual environment interface. The long-range goal is to create a simplistic virtual representation of the environment that includes only features related to the current navigational task and/or interactive needs of the person. In a completed study, the use of digital infrared transmitters as beacons representing salient features of the environment was explored. The purpose of a current study now in progress is to evaluate and compare various user interface structures that were suggested by subjects during the preliminary study. The problem of interest in the current study is street-crossing; however, the results of this research should be applicable to many other problems, including identifying and locating building entrances, and identifying, locating and interacting with electronic devices such as information kiosks, automated teller machines, and self-serve point-of-sale terminals. The long-range result desired is a wearable computer with which one can easily identify and interact with a wide variety of devices in the environment via one familiar, easy-to-use interface.     

Genetic effects of 1,3-butadiene and associated risk for heritable damage

A summary of the results of the studies conducted in the EU Project "Multi-endpoint analysis of genetic damage induced by 1,3-butadiene and its major metabolites in somatic and germ cells of mice, rats and man" is presented. Results of the project are summarized on the detection of DNA and hemoglobin adducts, on the cytotoxic and clastogenic effects in somatic and germinal cells of mice and rats, on the induction of somatic mutations at the hprt locus of experimental rodents and occupationally exposed workers, on the induction of dominant lethal mutations in mice and rats, and on heritable translocations induced in mice, after exposure to butadiene (BD) or its major metabolites, butadiene monoepoxide (BMO), diepoxybutane (DEB) and butadiene diolepoxide (BDE). The primary goal of this project was to collect experimental data on the genetic effects of BD in order to estimate the germ cell genetic risk to humans of exposure to BD. To achieve this, the butadiene exposure are based on data for heritable translocations and bone marrow micronuclei induced in mice and chromosome aberrations observed in lymphocytes of exposed workers. A doubling dose for heritable translocations in human germ cells of 4900 ppm/h is estimated, which, assuming cumulative BD exposure over the sensitive period of spermatogenesis, corresponds to 5-6 weeks of continuous exposure at the workplace to 20-25 ppm. Alternatively, the rate of heritable translocation induction per ppm/h of BD exposure is estimated to be approximately 0.8 per million live born, compared to a spontaneous incidence of balanced translocations in humans of approximately 800 per million live born. These estimates have large confidence intervals and are only intended to indicate orders of magnitude of human genetic risk. These risk estimates are based on data from germ cells of BD-exposed male mice. The demonstration that clastogenic damage was induced by DEB in preovulatory oocytes at doses which were not ovotoxic implies that additional studies on the response of mammalian female germ cells to BD and its metabolites are needed. The basic assumption of the above genetic risk estimates is that experimental mouse data obtained after BD exposure can be extrapolated to humans. Several points exist in the present report and in the literature which contradict this assumption: (1) the level of BMO-hemoglobin adducts was significantly elevated in BD-exposed workers; however, it was considerably lower than would have been predicted from comparable rat and mouse exposures; (2) the concentrations of the metabolites DEB and BMO were significantly higher in mouse than in rat blood after BD exposure. Thus, while metabolism of BD is qualitatively similar in the two species, it is quantitatively different; (3) no increase of HPRT mutations was shown in 19 workers exposed on average to 1.8 ppm of BD, while in a different population of workers from a US plant exposed on average to 3.5 ppm of BD, a significant increase of HPRT variants was detected; and (4) data from cancer bioassays and cancer epidemiology suggest that rat is a more appropriate model than mouse for human cancer risk from BD exposure. However, the dominant lethal study in rats gave a negative result. At present, we do not know which BD metabolite(s) may be responsible for the genetic effects even though the bifunctional alkylating agent DEB is the most likely candidate for the induction of clastogenic events. Unfortunately, methods to measure DEB adducts in hemoglobin or DNA are only presently being developed. Despite these several uncertainties the use of the mouse genetic data is regarded as a justifiable and conservative approach to human genetic risk estimation given the considerable heterogeneity observed in the biotransformation of BD in humans.     

The syndrome of depressive depersonalization

Nineteen patients (9 men, 10 women aged 22--38 years) with depressions were examined. The phenomena of anesthesia of ideatoric functions dominated in clinical picture of such depression. This depression is defined as the depression of estrangement. Psychopathologic differentiation of mental estrangement in the structure of depression and in similar disorders of self-consciousness which were formed in depressions under conditions of "transitional syndrome" (according to G.Gross) is outlined. This syndrome is characterised by irreversible negative disorders of "defective depersonalization". The following signs permit to distinguish depression of estrangement from "transitional syndrome": partiality of the estrangement's phenomenon; connection between psychopathologic formations and pathology of imagination (figurative expressiveness, demonstrativity, lability to psychogenic and medical actions); conformity of the syndrome's structure and characteristics of premanifested personality's structure (combination of hyperthymic features with histrionic and/or narcissic ones). "Apperceptive anesthesia" is suggested for designation of the variant of the depression described.     

The Ashkenazic Jewish Bloom syndrome mutation blmAsh is present in non-Jewish Americans of Spanish ancestry

Bloom syndrome (BS) is more frequent in the Ashkenazic Jewish population than in any other. There the predominant mutation, referred to as "blmAsh," is a 6-bp deletion and 7-bp insertion at nucleotide position 2281 in the BLM cDNA. Using a convenient PCR assay, we have identified blmAsh on 58 of 60 chromosomes transmitted by Ashkenazic parents to persons with BS. In contrast, in 91 unrelated non-Ashkenazic persons with BS whom we examined, blmAsh was identified only in 5, these coming from Spanish-speaking Christian families from the southwestern United States, Mexico, or El Salvador. These data, along with haplotype analyses, show that blmAsh was independently established through a founder effect in Ashkenazic Jews and in immigrants to formerly Spanish colonies. This striking observation underscores the complexity of Jewish history and demonstrates the importance of migration and genetic drift in the formation of human populations.     

Comparison of paper-and-pencil versus Web administration of the Youth Risk Behavior Survey (YRBS): Participation,data quality,and perceived privacy and anonymity

The Youth Risk Behavior Surveillance System (YRBSS) monitors priority health-risk behaviors among US high school students. To better understand the ramifications of changing the YRBSS from paper-and-pencil to Web administration, in 2008 the Centers for Disease Control and Prevention conducted a study comparing these two modes of administration. Eighty-five schools in 15 states agreed to participate in the study. Within each participating school, four classrooms of students in grades 9 or 10 were randomly assigned to complete the Youth Risk Behavior Survey questionnaire in one of four conditions (in-class paper-and-pencil, in-class Web without programmed skip patterns, in-class Web with programmed skip patterns, and “on your own” Web without programmed skip patterns). Findings included less missing data for the paper-and-pencil condition (1.5% vs. 5.3%, 4.4%, 6.4%; p < .001), less perceived privacy and anonymity among respondents for the in-class Web conditions, and a lower response rate for the “on your own” Web condition than for in-class administration by either mode (28.0% vs. 91.2%, 90.1%, 91.4%; p < .001). Although Web administration might be useful for some surveys, these findings do not favor the use of a Web survey for the YRBSS.     

虚拟MIMO传感器网络中一种联合网络效用和生存时间优化的分布式算法

虚拟(协作式)MIMO技术被认为是传感器网络中有效的节能解决方案之一,然而,现有虚拟MIMO传输策略的设计大多只关注如何有效降低网络能耗,而很少关注反映网络性能的其他指标,例如网络效用(Network Utility),该指标反映了网络数据采集和传输量的多少.为了联合优化网络效用和网络生存时间这两个网络性能参数.本文首先分析虚拟MIMO传输能耗特点,然后基于网络效用最大化(Network Utility Maximization)思想对虚拟MIMO传感器网络进行联合网络生存时间和网络效用的优化建模.在该模型的求解过程中,通过使用对偶分解技术将原需要集中计算的优化问题分解为可以在不同节点上进行计算的子优化问题,并得出一种联合优化网络效用和生存时间的分布式优化算法.该算法的仿真结果显示,网络中的虚拟MIMO节点仅需要交互邻居节点信息,通过有限次的迭代计算,就能收敛到全局最优的发送速率以及功率值.从而使系统总的效用和网络生存时间之间能够达到帕累托(Pareto)最优平衡.     

iDCX 51在Webit上的设计与实现

Webit是一个独立的、低成本的网络服务器,由东大新业技术股份有限公司研制成功.iDCX 51是Intel公司开发的实时操作系统,在工业控制等领域已成功应用,为使其能在Webit中也能够运行,以增强Webit的性能,对此本文以Webit内部单片机AT90S8515为例介绍iDCX 51往Webit中移植的设计与实现,并对移植后的时间性能进行了测试与对比分析,得知其任务切换时间与最大中断禁止时间这两项关键的时间性能指标分别减少33.3%和31.9%,表明系统移植后实时性得到了提高.     

Linear-Time Recognition of Helly Circular-Arc Models and Graphs

A circular-arc model ℳ is a circle C together with a collection A\mathcal{A} of arcs of C. If A\mathcal{A} satisfies the Helly Property then ℳ is a Helly circular-arc model. A (Helly) circular-arc graph is the intersection graph of a (Helly) circular-arc model. Circular-arc graphs and their subclasses have been the object of a great deal of attention in the literature. Linear-time recognition algorithms have been described both for the general class and for some of its subclasses. However, for Helly circular-arc graphs, the best recognition algorithm is that by Gavril, whose complexity is O(n ³). In this article, we describe different characterizations for Helly circular-arc graphs, including a characterization by forbidden induced subgraphs for the class. The characterizations lead to a linear-time recognition algorithm for recognizing graphs of this class. The algorithm also produces certificates for a negative answer, by exhibiting a forbidden subgraph of it, within this same bound.     

Introducing the IA-64 architecture

Microprocessors continue on the relentless path to provide more performance. Every new innovation in computing-distributed computing on the Internet, data mining, Java programming, and multimedia data streams-requires more cycles and computing power. Even traditional applications such as databases and numerically intensive codes present increasing problem sizes that drive demand for higher performance. Design innovations, compiler technology, manufacturing process improvements, and integrated circuit advances have been driving exponential performance increases in microprocessors. To continue this growth in the future, Hewlett Packard and Intel architects examined barriers in contemporary designs and found that instruction-level parallelism (ILP) can be exploited for further performance increases. This article examines the motivation, operation, and benefits of the major features of IA-64. Intel's IA-64 manual provides a complete specification of the IA-64 architecture