Cardiovascular and subjective effects of intravenous cocaine administration in humans

Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of dextroamphetamine sulfate. Measures of cardiovascular and subjective effects were made. Generally parallel dose-effect functions were obtained for heart rate, blood pressure, Addiction Research Center Inventory scores, Profile of Mood Scales, and subject ratings. A substantial effect on each of these variables was recorded after 8 mg of cocaine. The increase continued and peaked at approximately 16 mg after which it usually leveled off. Ten milligrams of dextroamphetamine generally had an effect comparable to 8 to 16 mg of cocaine.     

基于LabVIEW DSC的监控软件的应用研究

本文介绍了一种适用于中小型过程控制系统的监控软件,该软件是基于LabVIEW DSC的设计方法,在实际运行中证明采用此种方法,使得软件的性价比比较高,同时验证了在过程控制中运用的可行性。     

PIC单片机在逆变电源系统中的应用

本文介绍了一种以高性能dsPIC30F2010控制器为内核的逆变电源系统,阐述了它的工作原理、硬件组成及软件设计。该逆变电源系统具有硬件电路简单、体积小、成本低等优点。经试验表明:电源动态响应速度快,输出波形失真小,可靠性高。     

优品打印，向专业和细节看齐

“……这时候，打印设备成了一个关键角色，它的专业性能不但承载着使用者即设计师的利益，而且还一定程度上承载了商业设计终端客户的利益。”[编者按]     

呼伦贝尔市双向HFC网络系统实现方案

在充分利用呼伦贝尔市广电网络分公司原有HFC网络设备的基础上增加回传功能模块，实现HFC网络双向传输功能。在HFC网上建立基于DOCSIS2．0的CM数据传输系统，实现HFC网络中视频、语音、数据等业务的融合。重点阐述CM系统中数据和语音业务的实现过程，包括物理链路的建立、媒质访问控制子层（MAC）的建立及传输汇聚子层（TC）的建立。     

Web服务调用特征模式的DBSCAN提取算法

随着网络上完成相同功能的Web服务数量不断增长,服务使用者在选择服务之前,通常需要根据服务的历史使用信息对未使用过的服务质量进行预测.而服务质量主要受到调用时刻用户输入、网络环境及服务运行环境的影响,一组输入、网络状态和服务器状态可能形成一个相对固定的服务调用模式,在该模式下各服务的执行质量保持相对稳定的范围内.为此本文提出了服务调用特征模式的概念,并对服务历史执行信息进行处理,改进DBSCAN算法从历史执行信息中挖掘出服务调用特征模式,在模式下服务的执行QoS稳定在一定范围内,从而为服务QoS预测提供方便.     

Chronic low back pain. What are the treatment options?

The fragile X mental retardation 1 gene (FMR1) mutation is strongly correlated with specific and marked neurobehavioral and neuroanatomical abnormalities. The protein product, FMRP, is highly expressed in neurons of the normal mammalian brain, and absent or in low levels in leukocytes from individuals with fragile X (FraX)-associated mental impairment. Inferences which arise from these findings are that FMRP has a critical role in the development and functioning of the brain, and that leukocyte-derived molecular assessments provide a good indicator of FMR1 expression in that organ. This latter conclusion appears true in most cases even though the typical FMR1 mutation is an unstable triplet repeat expansion which demonstrates somatic heterogeneity within and across tissues. Blood to brain correspondence in FraX patients has only rarely been confirmed by the direct study of human brain specimens and, to our knowledge, it has never been studied in living individuals with the FMR1 mutation. In this report, we describe the FMR1 patterns in olfactory neuroblasts (ON) from two living brothers with expansion mutations in their leukocytes who are mentally retarded and autistic. ON were chosen for study because they are accessible neurons closely linked to the brain. In both subjects, the ON genotype was highly, but not perfectly, consistent with that observed in leukocytes. Protein phenotypes across tissues were completely consistent showing the absence of FMRP-immunoreactivity (-ir). These results augment the limited amount of direct evidence which indicates that FMR1 mutation patterns in leukocytes are a good, albeit potentially fallible, reflection of such patterns in the brain. This report further demonstrates the feasibility of using ON samples to evaluate the FMR1 mutation in humans in vivo.     

基于Web的模架数据库设计与实现

网络的出现，使数据库技术在Internet/Intranet条件下得到了迅速的发展。目前，Internet/Intranet下的数据库实现方式成为数据库技术的一个热点。本文通过对基于ASP，ADO以及ActiveX技术的探索，提出了一种基于Web的注塑模模架数据库解决方案。通过对塑料制品尺寸的优化，向用户推荐合理的注塑模标准模架。