Percutaneous transjejunal biliary intervention: 10-year experience with access via Roux-en-Y loops

Ancylostoma duodenale is still the dominant hookworm species in the Mediterranean area, India, China and Japan. In the present study, biopsied materials were taken from the small intestine of 30 patients infected only with A. duodenale and 12 cross matched controls. The results showed some pathological changes in severely infected cases. However, normal or insignificant changes were seen in the enzymatic activity of the intestinal mucosa.     

Comparison of PCR and pp65 antigenemia assay with quantitative shell vial culture for detection of cytomegalovirus in blood leukocytes from solid-organ transplant recipients

This study compared PCR and an assay for cytomegalovirus (CMV) pp65 antigenemia (CMV-vue; INCSTAR Corp.) with a quantitative shell vial culture (QSVC) technique for the detection of CMV in serial blood specimens from 46 solid-organ transplant recipients. In a comparison based on 535 specimens tested by PCR and QSVC, CMV was detected by PCR in 41 and by QSVC in 37 of 43 recipients at risk of CMV infection. The mean number of days after transplantation of initial detection of CMV was 29.9 for PCR and 34.0 for QSVC (P = 0.01). The antigenemia assay was performed on 395 specimens, including 304 of those also tested by PCR. In these specimens, CMV was detected by the antigenemia assay, QSVC, and PCR in 30, 32, and 35 (respectively) of 38 patients at risk, with no statistically significant difference in the time to detection. Each of the assays detected CMV in similar proportions of patients with and without clinically significant CMV infection. PCR stayed positive longer after transplantation than the other assays but frequently returned to negative when more than 6 months had elapsed after transplantation. The antigenemia assay and PCR stayed positive longer after institution of antiviral therapy than QSVC. PCR can provide highly sensitive detection of CMV viremia, but a PCR assay for CMV is not yet available in kit form. The pp65 antigenemia assay and shell vial culture are quantifiable and comparable in sensitivity. Either is recommended for rapid detection of CMV in blood specimens from solid-organ transplant recipients.     

Segregation and integration of cytoplasmic and nuclear materials during cleavage and induced fusion of blastomeres of mouse early embryos

Phenylbutazone was administered intravenously (i.v.) to a group of four lactating cows at a dosage of 6 mg/kg body weight. Whole plasma, protein-free plasma and milk were analysed for phenylbutazone residues. Pharmacokinetic parameters of total and free phenylbutazone in plasma were calculated using a non compartmental method. In regards to whole plasma data, the mean volume of distribution at steady state (Vss), was 147 mL/kg body weight, with a mean (+/-SEM) terminal elimination half-life (t1/2) of 40+/-6 h. The mean clearance (Cl) was 3 mL/h/kg body weight. The Vss as determined from the protein-free plasma fraction was 50021 mL/kg body weight. This larger Vss of free phenylbutazone compared to total plasma phenylbutazone was attributed to a high degree of plasma protein binding, as well as the greater penetration of free phenylbutazone into tissues. The mean t1/2 of free phenylbutazone was 39+/-5 h. This similarity to the t1/2 estimated from total plasma phenylbutazone data is attributed to an equilibrium between free and plasma phenylbutazone during the terminal elimination phase. Mean t1/2 as determined from milk, applying a urinary excretion rate model, was 47+/-4 h. Milk clearance of phenylbutazone was 0.009 mL/h/kg body weight, or about 0.34% of total body clearance. Furthermore, evidence suggests that phenylbutazone either binds to milk proteins, or is actively transported into milk, as its concentration in milk was greater than that predicted due to a simple partitioning from plasma into milk.     

4,4′,4″-三氨基三苯胺的合成

本文从对氯硝基苯和对硝基苯胺出发,经过两步反应合成了三偶氮类光导材料的重要中间体4,4′,4″-三氨基三 苯胺,其中第一反应采用KF/季铵盐催化法,收率48.4％,第二步反应采用钯碳催化加氢法,收率91.4％。     

溶液共混法制备高强度淀粉基完全生物降解塑料薄膜

利用一步溶液共混法，将预糊化的淀粉糊与PvA溶液共混，用乙二醛进行交联，制备淀粉／聚乙烯醇（PVA）完全生物降解塑料薄膜。研究不同乙二醛和甘油的用量对薄膜性能的影响。薄膜的力学性能、热性能和微观形态表征表明，淀粉／PvA体系具有较好的相容性和较高的力学性能，薄膜的拉伸强度和断裂伸长率分别可达到28．52MPa和307．5％。     

基于局部搜索和整体优化的客车杆件截面参数正向设计

首先建立了局部一维搜索方法,以客车车身线框模型与型钢截面库为基础,通过截面库优化排序、杆件局部模型一维搜索以及局部-整体迭代等优化步骤,得出一个满足多工况强度要求的车身结构杆件截面尺寸下限。然后通过灵敏度分析选择关键杆件,利用多目标遗传算法NSGA-II对选定杆件的截面尺寸在截面库的范围内进行优化,以提高整体刚度及模态性能。最后在某承载式客车车身杆件截面优化设计中,将该方法的优化结果作为设计输入,结果表明,车身结构的最终方案具有明显的轻量化效果。     

880 mm精轧机组的现代化改造

本文从改造内容、新增设备的性能参数、主要设备技术水平和设计特点等方面介绍了凌钢880 mm精轧机组的现代化改造。     

基于CAE分析的汽车制动液罐注射模设计

分析了汽车制动液罐注射件的结构特点,使用Moldflow软件对制品的注射成型过程进行CAE分析,确定了模具的浇注系统和成型工艺条件。模具为三板式点浇口结构,采用嵌件抽芯、斜导柱抽芯和液压抽芯相结合的方式实现模具的抽芯要求,并在此基础上完成了模具设计。     

0.618法在一步成形模拟方法中的应用

合理地选择冲压件的毛坯外形 ,可以提高板料的成形性 ,同时也可以提高材料利用率。本文着重研究了一步成形模拟方法中松弛因子对收敛的稳定性和收敛效率的影响问题 ,提出了一种基于 0 618法的松弛因子优化算法 ,并且设计编制了计算程序。通过球冠、L形件、行李箱盖外板、T形件 4个算例 ,与一系列未经优化的固定松弛因子结果进行了比较 ,验证了此方法的有效性