Safety and reliability in superconducting fusion magnet systems

Superconducting toroidal field coils for future commercial Tokamak reactors must operate safely and reliably for periods of up to 30 years or more with minimal interruption for maintenance. This paper represents an initial attempt to consider safety and reliability issues for superconducting fusion magnets. Goals and approaches for safety and reliability are characterized. Possible accident initiators are identified, and the effect of mechanical, thermal, and electrical factors are examined, by using some early Tokamak reactor concepts as illustrations. Principal factors in magnet instrumentation and control are identified, and the role of engineered-safety features are discussed.     

5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils

PURPOSE: To determine whether a hooked appearance of the soft palate can be seen in awake patients with snoring with or without obstructive sleep apnea syndrome (OSAS) on cephalometric radiographs and computed tomographic (CT) scans. MATERIALS AND METHODS: One hundred thirty-one patients with snoring underwent cephalometric radiography, with which the posterior airway space, soft palate length and width, and distance between the hyoid bone and mandibular plane were measured, and/or pharyngeal CT, with which the luminal areas of the airway at the naso-, oro-, and hypopharyngeal levels were measured. RESULTS: Of the 131 patients, 96 had OSAS, and 35 had snoring. Nine of 96 patients with OSAS had soft palate hooking on awake pharyngeal CT or cephalometric images. No patient with snoring alone had hooking. Patients with hooking had a larger posterior airway space than did patients with OSAS without hooking (P = .05), and an enlarged (> or = 15-mm) posterior airway space was more frequent in patients with hooking (eight of nine patients) than in those without hooking (34 of 87) (P < .01). Oropharyngeal and hypopharyngeal areas were significantly larger in patients with hooking than in patients without hooking or in patients with snoring (P < or = .04). CONCLUSION: Cephalometric radiography and CT can demonstrate hooking of the soft palate in awake patients. This finding indicates a high risk for OSAS.     

The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster

The genes of the trithorax group (trxG) in Drosophila melanogaster are required to maintain the pattern of homeotic gene expression that is established early in embryogenesis by the transient expression of the segmentation genes. The precise role of each of the diverse trxG members and the functional relationships among them are not well understood. Here, we report on the isolation of the trxG gene moira (mor) and its molecular characterization. mor encodes a fruit fly homolog of the human and yeast chromatin-remodeling factors BAF170, BAF155, and SWI3. mor is widely expressed throughout development, and its 170-kDa protein product is present in many embryonic tissues. In vitro, MOR can bind to itself and it interacts with Brahma (BRM), an SWI2-SNF2 homolog, with which it is associated in embryonic nuclear extracts. The leucine zipper motif of MOR is likely to participate in self-oligomerization; the equally conserved SANT domain, for which no function is known, may be required for optimal binding to BRM. MOR thus joins BRM and Snf5-related 1 (SNR1), two known Drosophila SWI-SNF subunits that act as positive regulators of the homeotic genes. These observations provide a molecular explanation for the phenotypic and genetic relationships among several of the trxG genes by suggesting that they encode evolutionarily conserved components of a chromatin-remodeling complex.     

Cognitive and affective components of reinforcement.

Responds to B. F. Skinner's (see record 1986-24282-001) article on components of reinforcement and examines why reinforcers strengthen behavior. The present author suggests that (1) the pleasing aspect, (2) the correct or incorrect aspect, and (3) the strengthening aspect are 3 equally important components of reinforcement, referring to the affective, cognitive, and behavioral characteristics of reinforcement, respectively. The occurrence of the 1st 2 characteristics is considered a necessary antecedent for the occurrence of the 3rd. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Psychometric properties of the Geriatric Depression Scale among the institutionalized aged.

Validity and reliability of the Geriatric Depression Scale (GDS) were examined among 806 nursing home and congregate apartment residents (mean age 84 years). The scale was highly internally consistent and, although a clean factor structure emerged, basically unidimensional. Test-retest reliability at 1 mo was good, but correlations with staff-rated depression were only moderate. GDS-based classifications of respondents as suffering possible major, minor, or no depression were fairly consistent with those based on a symptom checklist and with clinical diagnoses. However, both the GDS and the checklist yielded high false negative rates vis à vis clinically diagnosed minor depression. There were no differences in reliability or validity for cognitively impaired and intact groups. GDS responses did not vary with age or length of institutionalization, but there was a positive correlation with functional disability and ill health. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Shallow-Etch Mesa Isolation of Graded-Bandgap “W”-Structured Type II Superlattice Photodiodes

Shallow-etch mesa isolation (SEMI) of graded-bandgap “W”-structured type II superlattice (GGW) infrared photodiodes provides a powerful means for reducing excess dark currents due to surface and bulk junction related processes, and it is particularly well suited for focal-plane array fabrication. In the n-on-p GGW photodiode structure the energy gap is increased in a series of steps from that of the lightly p-type infrared-absorbing region to a value typically two to three times larger. The wider gap levels off about 10 nm short of the doping-defined junction, and continues for another 0.25 μm into the heavily n-doped cathode before the structure is terminated by an n ⁺-doped InAs top cap layer. The increased bandgap in the high-field region near the junction helps to strongly suppress both bulk tunneling and generation–recombination (G–R) current by imposing a much larger tunneling barrier and exponentially lowering the intrinsic carrier concentration. The SEMI approach takes further advantage of the graded structure by exposing only the widest-gap layers on etched surfaces. This lowers surface recombination and trap-assisted tunneling in much the same way as the GGW suppresses these processes in the bulk. Using SEMI, individual photodiodes are defined using a shallow etch that typically terminates only 10 nm to 20 nm past the junction, which is sufficient to isolate neighboring pixels while leaving the narrow-gap absorber layer buried 100 nm to 200 nm below the surface. This provides for separate optimization of the photodiode’s electrical and optical area. The area of the junction can be reduced to a fraction of that of the pixel, lowering bulk junction current, while maintaining 100% optical fill factor with the undisturbed absorber layer. Finally, with the elimination of deep, high-aspect-ratio trenches, SEMI simplifies array fabrication. We report herein results from SEMI-processed GGW devices, including large-area discrete photodiodes, mini-arrays, and a focal-plane array. Current–voltage data show strong suppression of side-wall leakage relative to that for more deeply etched devices, as well as scaling of dark current with junction area without loss of quantum efficiency.