Cycle time distribution in circulating systems

The cycle time distribution (CTD) within closed, continuously circulating systems is defined and related to the residence time distributions of flow regions which make up such systems. Examples of the application of the CTD are noted and experimental methods for determining CTDs for various systems are summarized.     

Evaluation of a four-channel multiplexed electrospray triple quadrupole mass spectrometer for the simultaneous validation of LC/MS/MS methods in four different preclinical matrixes

A four-channel multiplexed electrospray interface on a triple quadrupole mass spectrometer was evaluated for the simultaneous validation of LC/MS/MS methods for the quantitation of loratadine and its metabolite, descarboethoxyloratadine, in four different biological matrixes. The assays were performed in rat, rabbit, mouse, and dog plasma from 1 to 1000 ng/mL using 96-well solid-phase extraction for sample preparation. The limit of quantitation of 1 ng/mL corresponded to 5.56 pg of each analyte injected on-column. For the drug, quality control samples (n = 6 at four concentrations) had precision ranging from 0.967 to 16.0% and accuracy ranging from -8.44 to 10.5% across all four species. For the metabolite, the precision ranged from 0.684 to 11.0% and the accuracy was between 6.36 and -9.06%. Intersprayer cross talk for the multiplexed electrospray ion source was evaluated as a function of analyte concentration and was less than 0.08% at concentrations as high as 1000 ng/mL. These results demonstrate the feasibility of using parallel analysis to reduce the time required for method validation and to increase sample throughput in drug development studies.     

Transition Metal Exchanged Zeolite Layers for Selectivity Enhancement of Metal-Oxide Semiconductor Gas Sensors

A novel method of improving the selectivity of metal oxide gas sensors has been developed by using catalytically active molecular sieve materials. They have been successfully introduced into a proprietary sensor array. The cracking patterns of linear alkanes over transition metal exchanged zeolite Y have been measured using a zeolite bed/GC/MS experimental set-up within a temperature range of 300degC to 400degC. Studies have been carried out regarding the effects of metal loading, zeolite type, material fabrication techniques, and operating temperature in relation to catalytic activity and selectivity. The composite sensors utilising the novel zeolite materials have been used in a custom built sensor rig that houses three dual electrode sensors and can measure real-time responses of these sensors to an introduced headspace generated from organic liquids     

Crossflow filtration testing of INEEL radioactive and non-radioactive waste slurries

Development of waste treatment processes for the remediation of radioactive wastes is currently under way at the Idaho Nuclear Technology and Engineering Center (INTEC), located at the Idaho National Engineering and Environmental Laboratory (INEEL). INTEC, formerly known as the Idaho Chemical Processing Plant, previously reprocessed nuclear fuel to retrieve fissionable uranium. Liquid waste raffinates resulting from reprocessing were solidified into a calcine material. Waste treatment processes currently being considered include the dissolution of the solidified calcine material and separation of residual undissolved solids (UDS). UDS in solution must be removed prior to downstream processes such as solvent extraction and ion exchange. Filtration experiments were conducted at the INEEL using a crossflow filter apparatus on radioactive and non-radioactive waste slurries [N.R. Mann, T.A. Todd, Evaluation and Testing of the Cells Units Crossflow Filter on INEEL Dissolved Calcine Slurries, INEEL/EXT-98-00749, Idaho National Engineering and Environmental Laboratory, Idaho Falls, ID, 1998]. The purpose of this testing was to evaluate the removal and operational efficiency of crossflow filtration on slurries of various solids loadings. The solids loadings tested were 0.19, 2.44 and 7.94 wt.%, respectively. A matrix of test patterns was used to determine the effects of transmembrane pressure and axial velocity on filtrate flux. Filtrate flux rates for each solids loading displayed a high dependence on transmembrane pressure, indicating that pressure filtration resistance limits filtrate flux. Filtrate flux rates for all solids loading displayed a negative dependency on axial velocity. This would suggest axial velocities tested were efficient at removing filter cake. Prior to testing of actual waste slurries, baseline water runs were performed. Filtrate flowrates observed during baseline water runs exhibited substantial decreases despite numerous backpulses and rinses, suggesting particles that were deeply embedded within the filter membrane as the result of shear-induced deagglomeration     

An undergraduate system-on-chip (SoC) course for computer engineering students

The authors have developed a senior-level undergraduate system-on-chip (SoC) course at San Jose State University, San Jose, CA, that emphasizes SoC design methods and hardware-software codesign techniques. The course uses a "real world" design project as the teaching vehicle and implements an SoC platform to control a five-axis robotic arm using Altera's state-of-the-art Excalibur chip. The Excalibur chip contains both ARM Corporation's embedded processor and a programmable logic device (PLD) array. The course goes through a complete hardware-software codesign flow from implementing custom hardware devices on a PLD to developing an embedded algorithm in a state-of-the-art design environment for a complete SoC solution. Students learn the Quartus II design environment by examining the sample design files in Altera's EXPA1 development kit and following the step-by-step instructions toward creating a simple embedded application. After this familiarization process, students define the architectural specifications of a memory-mapped servo controller, implement it in the Excalibur's PLD array, and interface this device with the ARM processor's internal bus to control each robotic arm servo. Functional regression tests and post-synthesis timing verification steps are applied to the servo controller following the implementation phase. Subsequently, students integrate the servo controller with the rest of the system and perform board-level functional verification tests to observe whether the robotic arm can move an object from a source to a destination point accurately. Students also develop an embedded algorithm, which translates user inputs in Cartesian coordinates into robotic arm movements in spherical coordinates during laboratory sessions.     

经济型数控车床两用机构

目前国内在车床数控化改造中,其结构形式不外乎有两种。一种是去掉“两箱”(溜板箱、进给箱),换上滚珠丝杠;另一种是保留两箱,但只能用滑动丝杠。本文提出一种两用机构,使得在保留两箱功用的同时,采用滚珠丝杠传动,从而使经济型数控车床既具有滚珠丝杠传动精确、摩擦力小的优点,又可以保留原机床进给传动系统,获得数控、普车两用功能。