Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis

We report that fragments of amino acid sequence recently described for tripeptidyl-peptidase I (TPP I) show that it is the rat homologue of the human CLN2 gene product that is deficient in classical late-infantile neuronal ceroid lipofuscinosis. This is unexpected, since the CLN2 protein has been thought to be a carboxyl-dependent endopeptidase, but TPP I is an exopeptidase possibly of serine-type.     

The impact of condom availability [correction of distribution] in Seattle schools on sexual behavior and condom use

OBJECTIVES: Ten Seattle high schools made condoms available through vending machines, baskets in school clinics, or both. This study measured the number of condoms that students obtained and subsequent changes in sexual behavior and condom use. METHODS: Schoolwide surveys were administered in spring 1993 and in spring 1995, before and during the condom availability program. These data were compared with data from nationally representative surveys administered at the same time. RESULTS: Seattle students obtained an average of 4.6 condoms per year, the vast majority from baskets and very few from vending machines. Relative to the national samples, the percentage of Seattle students who had ever had sex remained stable after the program began; current sexual activity decreased significantly; and the percentage of sexually experienced students who used a condom the last time they had sex decreased significantly, particularly in the 5 schools with baskets of condoms in clinics. CONCLUSIONS: Making condoms available in Seattle schools enabled students to obtain relatively large numbers of condoms but did not lead to increases in either sexual activity or condom use.     

Reduplicative paramnesia: Rehabilitation of content-specific delusion after brain injury.

ABSTRACT. Reduplicative paramnesia (RP) is one of several rare content-specific delusions that may be associated with specific central nervous system lesions and disease. RP involves the assertion that a geographic location exists simultaneously in more than one place. Correct identification of this syndrome and its neurological etiology is essential because misdiagnosing RP as a psychiatric disorder may lead to unnecessary use of neuroleptics and an increased risk of iatrogenic complications. The rehabilitation psychologist has an important role in treating the patient with RP, as well as educating family and other treating professionals regarding this syndrome. A case of RP arising from subarachnoid hemorrhage is presented with discussion of the rehabilitation course leading to the resolution of the RP. The neuropsychological and psychological underpinnings of RP are discussed, in addition to recommendations for rehabilitation. (PsycINFO Database Record (c) 2010 APA, all rights reserved)