聚氯乙烯生产中关键工序的危险因素分析和控制措施

总结了氯乙烯合成与聚合工序的生产装置和工艺过程中的危险因素及安全控制措施。     

甲磺酸倍他司汀片的离子色谱法测定

甲磺酸倍他司汀经氧瓶燃烧后用吸收液吸收,结构中的硫氧化成硫酸根,采用离子色谱法测定,并根据甲磺酸倍他司汀化学式的计量关系求出样品中有效药物的含量.结果硫在0.02～60 μg·m<'-1>浓度范围内线性关系良好,平均回收率为98.8%,RSD为0.15%.     

虚拟三维交互技术的工业设计应用

虚拟三维交互技术广泛应用工业设计的多个过程,是现代工业设计一种不可或缺的重要设计方法,也是目前最流行的产品开发理念.本文介绍了虚拟三维交互工业设计的内容及技术支持;交互性、网络化、高效率、绿色设计的应用特点;在产品设计制造、展示体验、推广销售过程中的应用等形式和优势.这种技术的应用既能够有效降低产品开发成本,又方便用户...     

基于室外风环境与热舒适度的城市设计改进策略——以北京西单商业街为例

城市室外风热环境对于城市生活品质起着不容忽视的作用,对于城市室外公共空间,如商业街,行人层高度风环境与热舒适度的优劣对其商业价值有着直接的影响.选取北京西单商业街为案例进行研究,基于北京夏季炎热高温冬季寒冷风强的地域气候特征,结合其数次城市设计环境改造,通过数值模拟手段,对北京西单商业街冬夏两季室外开放空间行人层风环境与热舒适度进行综合评价,针对现存导致室外风热环境恶化的城市设计问题提出改进措施,并总结提升城市户外风热环境品质的普适性城市设计策略.结果可从户外舒适度的角度提供同类型商业街区的城市设计参考,从而创造宜居的城市户外环境与空间.     

自感式电磁阻尼器的研究

通过分析国内外转子振动控制技术,提出了自感式电磁阻尼器的转子横向振动主动控制的设计构思,并以前置滤波器的引入来实现系统功能,同时进行对模型的仿真研究,论证了自感式电磁阻尼器的可行性,具有结构简单,经济实用的特点。     

灌浆技术在紫山灰坝迎灰坡裂缝处理中的应用

本文分析了紫山灰坝迎灰坡裂缝的成因，并介绍了充填式灌浆处理方法，效果良好。     

轻集料混凝土多孔砖砌体基本力学性能试验研究

对在夏热冬冷地区应用达到自保温体系要求的轻集料混凝土多孔砖砌体的基本力学性能进行试验研究,并通过试验分析了块体高度、试件厚度及砌筑形式对砌体抗压强度的影响.试验结果表明,此种自保温墙材可应用于承重结构.     

A randomized phase-II study of BB-10010 (macrophage inflammatory protein- 1alpha) in patients with advanced breast cancer receiving 5-fluorouracil, adriamycin, and cyclophosphamide chemotherapy

BB-10010 is a variant of the human form of macrophage inflammatory protein-1alpha (MIP-1alpha), which has been shown in mice to block the entry of hematopoietic stem cells into S-phase and to increase their self-renewal capacity during recovery from cytotoxic damage. Its use may constitute a novel approach for protecting the quality of the stem cell population and its capacity to regenerate after periods of cytotoxic treatment. Thirty patients with locally advanced or metastatic breast cancer were entered into the first randomized, parallel group controlled phase II study. This was designed to evaluate the potential myeloprotective effects of a 7-day regimen of BB-10010 administered to patients receiving six cycles of 5-fluorouracil (5-FU), adriamycin, and cyclophosphamide (FAC) chemotherapy. Patients were randomized, 10 receiving 100 microgram/kg BB-10010, 11 receiving 30 microgram/kg BB-10010, and nine control patients receiving no BB-10010. BB-10010 was well-tolerated in all patients with no severe adverse events related to the drug. Episodes of febrile neutropenia complicated only 4% of the treatment cycles and there was no difference in incidence between the treated and nontreated groups. Studies to assess the generation of progenitor cells in long-term bone marrow cultures were performed immediately preceding chemotherapy and at the end of six dosing cycles in 18 patients. Circulating neutrophils, platelets, CD 34(+) cells, and granulocyte/macrophage colony-forming cell (GM-CFC) levels were determined at serial time points in cycles 1, 3, and 6. The results showed similar hemoglobin and platelet kinetics in all three groups. On completion of the six treatment cycles, the average pretreatment neutrophil levels were reduced from 5.3 to 1.7 x 10(9)/L in the control patients and from 4.3 to 1.9 and 4.5 to 2.5 x 10(9)/L in the 30/100 microgram/kg BB-10010 groups, respectively. Relative to their pretreatment values, 50% of the patients receiving BB-10010 completed the treatment with neutrophil values significantly higher than any of the controls (P = .02). Mobilization of GM-CFC was enhanced by BB-10010 with an additional fivefold increase over that generated by chemotherapy alone, giving a maximal 25-fold increase over pretreatment values. Bone marrow progenitor assays before and after this standard regimen of chemotherapy indicated little long-term cumulative impairment to recovery from chemotherapy. Despite the limited cumulative damage to the bone marrow, which may have minimized the protective value of BB-10010 during this regimen of chemotherapy, better recovery of neutrophils in the later treatment cycles with BB-10010 was indicated in a number of patients.     

Detection and partial characterization of bacteriocin in the methanotrophic bacterium Methylobacter bovis

The strain Methylobacter bovis 98 was selected among methanotrophic bacteria as one of the most active producers of secretory bacteriocin-like compounds. In the above strain this compound was shown to be a protein with a molecular weight of about 70 kD, relatively thermostable, having a bactericidal effect on closely related organisms. Its properties as a whole are consistent with the accepted definition of bacteriocins, which so far have not been found in this group of microorganisms. A methodical approach that combines electrophoretic separation of secretory proteins and testing their antibacterial activity directly in polyacrylamide gel allowed us for the first time to identify bacteriocin in methanotrophic bacterial culture.